Compare Lodine vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lodine
(etodolac)

Percocet
(oxycodone / acetaminophen)

Coming soon.Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Coupons for Lodine
Best available price for 60 (300mg) capsules of etodolac
Coupons for Percocet
Best available price for 120 (5mg/325mg) tablets of percocet
Reviews & ratings
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Have you used Lodine (etodolac)?
Worth itNot sureNot worth it
Reviews for Percocet
70%
-40% worse vs. Lodine
49%
-29% worse vs. Lodine
15%
+5% better vs. Lodine
1399 reviews
Have you used Percocet (oxycodone / acetaminophen)?
Worth itNot sureNot worth it
Side effects
LodinePercocet

We haven’t found good data for Lodine side effects.

FDA side effect reports for Lodine »

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »
How it works
LodinePercocet
Coming soon.Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
LodinePercocet
Prescription only
Available as
LodinePercocet
  • Pill
  • Extended release
  • Pill
  • Oral solution
Used for
LodinePercocet
  • Juvenile Rheumatoid Arthritis Osteoarthritis Pain Rheumatoid Arthritis
Risk factors for serious side effects
LodinePercocet
    Coming soon.
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen
    • Age 65 or greater
    • Higher dose
    Detailed Percocet (oxycodone / acetaminophen) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    LodinePercocet
    No alcohol related info.
    • Avoid alcohol.
    Food
    LodinePercocet
    No food related info.
    • Take it with food to lower the chance of an upset stomach.
    Kidneys and liver
    LodinePercocet
    No kidneys and liver related info.
    • Don't take more than instructed to prevent liver damage.
    • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
    Pain
    LodinePercocet
    No pain related info.
    • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Generally considered stronger than Norco or other combination pain medicine for treating pain.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    Sleep
    LodinePercocet
    No sleep related info.
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common, but your body may adjust.
    Upsides and benefits
    LodinePercocet
    Coming soon
    • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relief for moderate to severe pain to improve quality of life.
    • Generally considered stronger than Norco or other combination pain medicine for treating pain.
    • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    Downsides and risks
    LodinePercocet
    Coming soon
    • Dizziness and drowsiness is common, but your body may adjust.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    Tips from our pharmacists for people taking the medication
    LodinePercocet
    Coming soon
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Starts working in 30 minutes.
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Can make you dizzy or drowsy.
    • Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    Learn more
    More about LodineSide effectsReviews & ratingsFDA package insert
    Have you used Lodine (etodolac)?
    Worth itNot sureNot worth it
    More about PercocetSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Percocet (oxycodone / acetaminophen)?
    Worth itNot sureNot worth it