Compare Lopressor vs. Bystolic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lopressor
(Metoprolol Tartrate)

Bystolic
(Nebivolol)

Lowers blood pressure and controls heart rate. Lopressor (Metoprolol Tartrate) is good for controlling chest pain and treating heart failure and heart attack. You have to take it with food, and you can't miss doses.Lowers blood pressure and controls heart rate. Bystolic (Nebivolol) is a good blood pressure-lowering medicine for people with heart conditions, and has fewer side effects than other beta blockers, but it's expensive. You can't miss doses.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.99103139013453Lopressor
Reviews for Lopressor (Metoprolol Tartrate)
61%
of people say Lopressor (Metoprolol Tartrate) is worth it
46%
say it works well
15%
say it's a big hassle
Reviews for Bystolic (Nebivolol)
51%
10% vs. Lopressor (Metoprolol Tartrate)
46%
Same vs. Lopressor (Metoprolol Tartrate)
18%
3% vs. Lopressor (Metoprolol Tartrate)
Side effects
LopressorBystolic
  • Abnormally slow heartbeat 9%
  • Low blood pressure 4%
  • First-degree heart block 3%
More Lopressor side effects »
  • Fatigue 4%
  • Headache 3%
  • Dizziness 2%
  • Diarrhea 1%
More Bystolic side effects »
How it works
LopressorBystolic
Lopressor (Metoprolol Tartrate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Bystolic (Nebivolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.
Type of medication
LopressorBystolic
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
LopressorBystolic
  • Pill
  • Pill
Used for (click to learn more)
LopressorBystolic
Risk factors for serious side effects
LopressorBystolic
  • Diabetes
    • Coronary artery disease
    • Heart failure
    • Major surgery requiring anesthesia
    • History of asthma
    Detailed Lopressor (Metoprolol Tartrate) risks & warnings »
    • Sudden discontinuation of medicine
    • History of asthma
    • History of diabetes
    • Age 65 years or older
    • Using other medicine(s) that slows the heart
    Detailed Bystolic (Nebivolol) risks & warnings »
    Pregnancy category
    LopressorBystolic
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    • Metoprolol tartrate is the immediate release version of Toprol XL. You have to take Metoprolol tartrate with food for it to work best. (On the other hand, you can take Toprol XL any time.)
    • Take it with food.
    No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    LopressorBystolic
    • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
    • A first-choice treatment for heart failure. May prevent long-term heart damage.
    • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
    • Controls your heart rate to reduce work for your heart.
    • A first-line treatment for heart failure and heart attack.
    • Helps to lower blood pressure if you can't use first-choice treatments or need additional blood pressure control.
    • Many beta blockers can worsen asthma or cause headaches, but Bystolic usually doesn't because it targets the heart more specifically and causes fewer side effects.
    Downsides and risks
    LopressorBystolic
    • Metoprolol tartrate is the immediate release version of Toprol XL. You have to take Metoprolol tartrate with food for it to work best. (On the other hand, you can take Toprol XL any time.)
    • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
    • You can't miss doses. Stopping Metoprolol tartrate suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
    • Can hide symptoms of low blood sugar if you're diabetic.
    • Not available in less expensive generic form.
    • You can't miss doses. Stopping Bystolic suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
    • Can hide symptoms of low blood sugar if you're diabetic.
    Tips from our pharmacists for people taking the medication
    LopressorBystolic
    • Take it with food.
    • Can cause dizziness in the first few days.
    • Can cause fatigue and headache.
    • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
    • This is the immediate release version. It also comes as an extended release form: Toprol XL (metoprolol succinate).
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Don't stop taking this medicine suddenly.
    • Can cause headache, dizziness, or feeling short of breath in the first few days.
    • If side effects don't go away, talk to your doctor about alternatives.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Don't stop taking this medicine suddenly.
    Learn more
    More about LopressorSide effectsReviews & ratingsAlternativesFDA package insert
    More about BystolicSide effectsReviews & ratingsAlternativesFDA package insert