Compare Lopressor vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lopressor
(metoprolol tartrate)

Microzide
(hydrochlorothiazide )

Lowers blood pressure and controls heart rate. Lopressor (metoprolol tartrate) lowers high blood pressure, controls chest pain, and helps treat heart failure and heart attack. You need to take it with food and can't miss a dose.Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.02Lopressor
Reviews for Lopressor (metoprolol tartrate)
62%
of people (All ages) say Lopressor (metoprolol tartrate) is worth it
47%
say it works well
15%
say it's a big hassle
464 reviews
Have you used Lopressor (metoprolol tartrate)?
Worth itNot sureNot worth it
Reviews for Microzide (hydrochlorothiazide )
47%
-15% worse vs. Lopressor (metoprolol tartrate)
31%
-16% worse vs. Lopressor (metoprolol tartrate)
16%
-1% worse vs. Lopressor (metoprolol tartrate)
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Side effects
Lopressorhydrochlorothiazide
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Diarrhea 5%
  • Itching or skin rash 5%
  • Shortness of breath 3%
  • Slowed heart rate 3%
  • Low blood pressure 4%
More Lopressor side effects »

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
How it works
Lopressorhydrochlorothiazide
Lopressor (metoprolol tartrate) is a beta blocker. It lowers blood pressure by slowing your heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.
Type of medication
Lopressorhydrochlorothiazide
Prescription only
Prescription only
Available as
Lopressorhydrochlorothiazide
  • Pill
  • Pill
Used for
Lopressorhydrochlorothiazide
Risk factors for serious side effects
Lopressorhydrochlorothiazide
  • Suddenly stopping Lopressor (metoprolol tartrate)
  • Coronary artery disease
  • Diabetes
    • Heart failure
    • Major surgery requiring anesthesia
    • Asthma
    • COPD
    Detailed Lopressor (metoprolol tartrate) risks & warnings »
    • Current electrolyte imbalance
    • Lower kidney function
    • Dehydration
    • History of sulfa allergies
    • History of gout
    • Current kidney problems
    • History of sulfa or penicillin allergies
    • Diabetes
    Detailed Microzide (hydrochlorothiazide ) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Food
    Lopressorhydrochlorothiazide
    • You need to take Lopressor (metoprolol tartrate) with food twice a day for it to work best.
    No food related info.
    Kidneys and liver
    Lopressorhydrochlorothiazide
    No kidneys and liver related info.
    • Requires routine blood tests to check kidney function.
    Pain
    Lopressorhydrochlorothiazide
    • Makes pain episodes less frequent and makes it easier to be active without having chest pain.
    No pain related info.
    Upsides and benefits
    Lopressorhydrochlorothiazide
    • A first-choice treatment to prevent chest pain (angina).
    • Makes pain episodes less frequent and makes it easier to be active without having chest pain.
    • A first-choice treatment for people who've had a heart attack.
    • Lopressor (metoprolol tartrate) lowers the risk of death during and after a heart attack.
    • Lopressor (metoprolol tartrate) is cheaper than the extended release version.
    • Does a good job getting rid of extra fluids in your body by making you urinate more.
    • A first-choice blood pressure treatment. Works especially well for people of African descent.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have high blood pressure and heart failure.
    • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
    • Can be good for patients with osteoporosis since it raises the body's level of calcium.
    Downsides and risks
    Lopressorhydrochlorothiazide
    • You need to take Lopressor (metoprolol tartrate) with food twice a day for it to work best.
    • Taking Lopressor (metoprolol tartrate) may make you feel more tired or out of breath during exercise or your normal daily routines. This gets better for most people, but for some it may not go away.
    • Not a first-choice treatment for high blood pressure, unless you have heart failure or heart disease. It can also be added to other medicines if your blood pressure is still too high.
    • Can hide symptoms of low blood sugar if you're diabetic.
    • You can't miss doses. Stopping Lopressor (metoprolol tartrate) suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    • Makes you urinate more often.
    • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
    • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
    • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
    Tips from our pharmacists for people taking the medication
    Lopressorhydrochlorothiazide
    • You should take Lopressor (metoprolol tartrate) with or after meals.
    • Lopressor (metoprolol tartrate) can make you feel dizzy for the first few days. It can also cause fatigue and headaches.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
    • Don't stop taking this medicine suddenly unless your doctor tells you to.
    • This is the immediate release version of the medication, so it needs to be taken twice a day. It's different from the extended release form: Toprol XL (metoprolol succinate).
    • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
    • It makes you urinate more often, so don't take it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    Learn more
    More about LopressorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Lopressor (metoprolol tartrate)?
    Worth itNot sureNot worth it
    More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Microzide (hydrochlorothiazide )?
    Worth itNot sureNot worth it