Compare Lopressor vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lopressor (metoprolol tartrate)

Prescription only
Lowers blood pressure and controls heart rate.

Lopressor (metoprolol tartrate) lowers high blood pressure, controls chest pain, and helps treat heart failure and heart attack. You need to take it with food and can't miss a dose.

5.0/ 7 average rating with 464 reviewsforLopressor
Removes water from the body, which lowers blood pressure.

Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.

4.5/ 7 average rating with 139 reviewsforhydrochlorothiazide
Upsides
  • A first-choice treatment to prevent chest pain (angina).
  • Makes pain episodes less frequent and makes it easier to be active without having chest pain.
  • A first-choice treatment for people who've had a heart attack.
  • Lopressor (metoprolol tartrate) lowers the risk of death during and after a heart attack.
  • Lopressor (metoprolol tartrate) is cheaper than the extended release version.
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
Downsides
  • You need to take Lopressor (metoprolol tartrate) with food twice a day for it to work best.
  • Taking Lopressor (metoprolol tartrate) may make you feel more tired or out of breath during exercise or your normal daily routines. This gets better for most people, but for some it may not go away.
  • Not a first-choice treatment for high blood pressure, unless you have heart failure or heart disease. It can also be added to other medicines if your blood pressure is still too high.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • You can't miss doses. Stopping Lopressor (metoprolol tartrate) suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$4
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Lowest price near you
$4
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Reviews
464 
62%
think this treatment is worth it
47%
think this treatment works well
15%
think this treatment is a hassle

Have you used Lopressor (metoprolol tartrate)?

Leave a review
139 
47%
think this treatment is worth it
31%
think this treatment works well
16%
think this treatment is a hassle

Have you used Microzide (hydrochlorothiazide (HCTZ))?

Leave a review
Side effects
7possible side effects
  • Tiredness
    10%
  • Dizziness
    10%
  • Depression
    5%
  • Diarrhea
    5%
  • Itching or skin rash
    5%
  • Shortness of breath
    3%
  • Slowed heart rate
    3%
See more detailed side effects
The Microzide (hydrochlorothiazide (HCTZ)) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Heart problems

    Suddenly stopping Lopressor (metoprolol tartrate)

    ...and 1 more risk factors

  • Masked symptoms of low blood sugar

    Diabetes

  • Increased symptoms of heart failure

    Heart failure

  • Increased risks during surgery

    Major surgery requiring anesthesia

  • Breathing problems

    Asthma

    ...and 1 more risk factors

See more detailed risks and warnings
  • Dehydration and electrolyte imbalance

    Current electrolyte imbalance

    ...and 2 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

  • Gout

    History of gout

    ...and 1 more risk factors

  • Vision problems

    History of sulfa or penicillin allergies

  • Higher blood sugars

    Diabetes

See more detailed risks and warnings