Compare Lopressor vs. Hyzaar

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lopressor
(metoprolol tartrate)

Hyzaar
(losartan / hydrochlorothiazide)

Lowers blood pressure and controls heart rate. Lopressor (metoprolol tartrate) lowers high blood pressure, controls chest pain, and helps treat heart failure and heart attack. You need to take it with food and can't miss a dose.Lowers blood pressure. Removes extra water from your body. Hyzaar (Losartan / Hydrochlorothiazide) is a good combination blood pressure-lowering medicine to try if your blood pressure is very high.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.02Lopressor
Reviews for Lopressor (metoprolol tartrate)
62%
of people (All ages) say Lopressor (metoprolol tartrate) is worth it
47%
say it works well
15%
say it's a big hassle
464 reviews
Have you used Lopressor (metoprolol tartrate)?
Worth itNot sureNot worth it
Reviews for Hyzaar (losartan / hydrochlorothiazide)
Not enough review data. Review it!
-37% worse vs. Lopressor (metoprolol tartrate)
Not enough review data. Review it!
+3% better vs. Lopressor (metoprolol tartrate)
Not enough review data. Review it!
-10% worse vs. Lopressor (metoprolol tartrate)
Have you used Hyzaar (losartan / hydrochlorothiazide)?
Worth itNot sureNot worth it
Side effects
LopressorHyzaar
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Diarrhea 5%
  • Itching or skin rash 5%
  • Shortness of breath 3%
  • Slowed heart rate 3%
  • Low blood pressure 4%
More Lopressor side effects »
  • Dizziness 3%
  • Upper respiratory infection 1%
  • Cough 1%
  • Back pain 1%
More Hyzaar side effects »
How it works
LopressorHyzaar
Lopressor (metoprolol tartrate) is a beta blocker. It lowers blood pressure by slowing your heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Hyzaar (Losartan / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure. Hydrochlorothiazide is a diuretic that removes extra water from your body. Losartan is an angiotensin receptor blocker (ARB) that relaxes your blood vessels to lower you blood pressure and allow more blood and oxygen to get to your heart and other organs.
Type of medication
LopressorHyzaar
Prescription only
Prescription only
Available as
LopressorHyzaar
  • Pill
  • Pill
Used for
LopressorHyzaar
Risk factors for serious side effects
LopressorHyzaar
  • Suddenly stopping Lopressor (metoprolol tartrate)
  • Coronary artery disease
  • Diabetes
  • Heart failure
  • Major surgery requiring anesthesia
Detailed Lopressor (metoprolol tartrate) risks & warnings »
  • Women of childbearing age
  • History of kidney problems
  • African descent
  • Current kidney problems
  • Medicine that affects potassium
Detailed Hyzaar (losartan / hydrochlorothiazide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
LopressorHyzaar
  • You need to take Lopressor (metoprolol tartrate) with food twice a day for it to work best.
No food related info.
Kidneys and liver
LopressorHyzaar
No kidneys and liver related info.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
  • Needs dose adjustment if you have liver problems.
  • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
  • Requires routine blood tests to check kidney function.
  • Hyzaar (Losartan / Hydrochlorothiazide) can affect the potassium level in your body. Too much potassium can cause heart problems and too little potassium can cause muscle problems. Baseline and routine lab tests are needed to measure your potassium and kidney function.
Pain
LopressorHyzaar
  • Makes pain episodes less frequent and makes it easier to be active without having chest pain.
No pain related info.
Upsides and benefits
LopressorHyzaar
  • A first-choice treatment to prevent chest pain (angina).
  • Makes pain episodes less frequent and makes it easier to be active without having chest pain.
  • A first-choice treatment for people who've had a heart attack.
  • Lopressor (metoprolol tartrate) lowers the risk of death during and after a heart attack.
  • Lopressor (metoprolol tartrate) is cheaper than the extended release version.
  • Lowers the risk of heart attack and stroke.
  • A first-choice treatment for severe high blood pressure, combining the benefits of two blood pressure-lowering medicines with a single pill.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Helpful in getting rid of extra fluids if you have issues with fluid balance (like in congestive heart failure).
  • Most people have few side effects.
Downsides and risks
LopressorHyzaar
  • You need to take Lopressor (metoprolol tartrate) with food twice a day for it to work best.
  • Taking Lopressor (metoprolol tartrate) may make you feel more tired or out of breath during exercise or your normal daily routines. This gets better for most people, but for some it may not go away.
  • Not a first-choice treatment for high blood pressure, unless you have heart failure or heart disease. It can also be added to other medicines if your blood pressure is still too high.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • You can't miss doses. Stopping Lopressor (metoprolol tartrate) suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Will make you urinate more often.
  • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
  • Not safe to use if you're pregnant.
  • Needs dose adjustment if you have liver problems.
  • Your skin will be more sensitive to the sun while taking this.
  • Won't work as well if you have severe kidney problems.
  • Shouldn't take if you have a sulfa allergy.
Tips from our pharmacists for people taking the medication
LopressorHyzaar
  • You should take Lopressor (metoprolol tartrate) with or after meals.
  • Lopressor (metoprolol tartrate) can make you feel dizzy for the first few days. It can also cause fatigue and headaches.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
  • Don't stop taking this medicine suddenly unless your doctor tells you to.
  • This is the immediate release version of the medication, so it needs to be taken twice a day. It's different from the extended release form: Toprol XL (metoprolol succinate).
  • Can cause dizziness in the first few days.
  • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
  • Tell your doctor about any dizziness or muscle weakness that doesn't go away.
  • Get immediate medical help if you notice any swelling, especially around your head and neck.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
Learn more
More about LopressorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lopressor (metoprolol tartrate)?
Worth itNot sureNot worth it
More about HyzaarSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Hyzaar (losartan / hydrochlorothiazide)?
Worth itNot sureNot worth it