Compare Losartan vs. Avapro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cozaar
(losartan)

Avapro
(irbesartan)

Lowers blood pressure. Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.Lowers blood pressure. Avapro (irbesartan) is a good blood pressure-lowering medicine that protects your kidneys and has few side effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.99Losartan
Reviews for Losartan
57%
of people (All ages) say Losartan is worth it
48%
say it works well
16%
say it's a big hassle
535 reviews
Have you used Cozaar (losartan)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Avapro (irbesartan)?
Worth itNot sureNot worth it
Side effects
LosartanAvapro
  • Upper respiratory infection 1%
  • Dizziness 1%
  • Back pain 1%
  • Nasal congestion 1%
  • Urinary tract infection 6%
  • Diarrhea 5%
  • Muscle weakness/fatiguea/fatigue 4%
  • Low red blood cells 3%
  • Low blood sugar 4%
  • Back pain 2%
More Losartan side effects »
  • Fatigue 1%
  • Diarrhea 1%
  • Heartburn 1%
More Avapro side effects »
How it works
LosartanAvapro
Cozaar (Losartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Avapro (irbesartan) is an angiotensin receptor blocker (ARB). It lowers blood pressure by blocking a chemical that tightens the blood vessels. This allows more blood and oxygen to get to your heart and other organs.
Type of medication
LosartanAvapro
Prescription onlyPrescription only
Available as
LosartanAvapro
  • Pill
  • Pill
Used for
LosartanAvapro
Risk factors for serious side effects
LosartanAvapro
  • Women of childbearing age
  • Concurrent liver disease
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
Detailed Cozaar (losartan) risks & warnings »
  • Women of childbearing age
  • History of kidney problems
  • African descent
  • Current kidney problems
  • Using medicines that increase potassium
Detailed Avapro (irbesartan) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
LosartanAvapro
  • Requires routine blood tests to check kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Avapro (irbesartan) can hurt your kidneys. If you already have kidney damage, Avapro (irbesartan) could make it worse. Your doctor will do regular blood tests to check your kidneys, usually before you start Avapro (irbesartan), and at least once a year while you're still on it.
  • You'll need to have blood tests done regularly since Avapro (irbesartan) can affect your kidneys and potassium levels.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
Upsides and benefits
LosartanAvapro
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Avapro (irbesartan) lowers your risk of heart attack and stroke.
  • It works similar to ACE inhibitors (like lisinopril), but it doesn't have the same side effects like coughing and facial swelling.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • It's recommended for people with heart failure since it lowers the risk of death and further damage to your heart.
  • Available in generic, and available with hydrochlorothiazide as a combination tablet.
Downsides and risks
LosartanAvapro
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • You'll need to get yearly blood tests while taking Avapro (irbesartan) to see how it is affecting your body.
  • It's not safe to use Avapro (irbesartan) if you're pregnant.
  • Avapro (irbesartan) can cause the level of potassium in your blood to go up.
  • You'll need to get medical help if you notice any unusual swelling around your head and neck.
  • Can't be used in children under 18.
Tips from our pharmacists for people taking the medication
LosartanAvapro
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
  • Avapro (irbesartan) can make you feel a little dizzy for the first few days.
  • You'll need to have blood tests done regularly since Avapro (irbesartan) can affect your kidneys and potassium levels.
  • Don't eat a lot of foods that are high in potassium or use salt substitutes that contain potassium.
  • Tell your doctor about any dizziness or muscle weakness that doesn't go away after the first few days.
  • Don't take Avapro (irbesartan) if you're pregnant.
Learn more
More about LosartanSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cozaar (losartan)?
Worth itNot sureNot worth it
More about AvaproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Avapro (irbesartan)?
Worth itNot sureNot worth it