Compare Losartan vs. Diovan HCT

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cozaar
(Losartan)

Diovan Hct
(Valsartan / Hydrochlorothiazide)

Lowers blood pressure. Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.Lowers blood pressure. Diovan Hct (Valsartan / Hydrochlorothiazide) is a good 2-in-1 blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.965648854961832Losartan
Reviews for Cozaar (Losartan)
57%
of people say Cozaar (Losartan) is worth it
47%
say it works well
16%
say it's a big hassle
Reviews for Diovan Hct (Valsartan / Hydrochlorothiazide)
63%
+6% vs. Cozaar (Losartan)
52%
+5% vs. Cozaar (Losartan)
19%
3% vs. Cozaar (Losartan)
Side effects
LosartanDiovan HCT
  • Urinary tract infection 6%
  • Diarrhea 5%
  • Low blood sugar 4%
  • Low blood pressure 4%
  • Muscle weakness/fatiguea/fatigue 4%
  • Hyperkalemia 4%
  • Chest pain 4%
  • Low red blood cells 3%
  • Muscular weakness 3%
  • Orthostatic hypotension 3%
More Losartan side effects »
  • Dizziness 4%
More Diovan HCT side effects »
How it works
LosartanDiovan HCT
Cozaar (Losartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Diovan Hct (Valsartan / Hydrochlorothiazide) is a combination medicine. Valsartan (an angiotensin receptor blocker) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.
Type of medication
LosartanDiovan HCT
Antihypertensive
Angiotensin receptor blocker
Prescription only
Antihypertensive
Angiotensin receptor blocker
Diuretic
Prescription only
Available as
LosartanDiovan HCT
  • Pill
  • Pill
Used for (click to learn more)
LosartanDiovan HCT
Risk factors for serious side effects
LosartanDiovan HCT
  • Women of childbearing age
  • Concurrent liver disease
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
Detailed Cozaar (Losartan) risks & warnings »
  • Women of childbearing age
  • African descent
  • History of kidney disease
  • History of lupus
  • Taking lithium
  • Allergies to penicillin or sulfonamides
  • History of gout
  • Current kidney problems
  • History of liver disease
Detailed Diovan Hct (Valsartan / Hydrochlorothiazide) risks & warnings »
Pregnancy category
LosartanDiovan HCT
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
  • Doesn't work as well in people with severe kidney problems.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
  • Diovan Hct (Valsartan / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
LosartanDiovan HCT
  • A first-choice blood pressure treatment for many people.
  • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Diovan HCT work together to lower blood pressure and remove extra water from your body.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
Downsides and risks
LosartanDiovan HCT
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
LosartanDiovan HCT
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
  • Makes you urinate more often, so avoid taking it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
Learn more
More about LosartanSide effectsReviews & ratingsAlternativesFDA package insert
More about Diovan HCTSide effectsReviews & ratingsAlternativesFDA package insert