Compare Losartan vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cozaar
(Losartan)

Zestril
(Lisinopril)

Lowers blood pressure. Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.965648854961832Losartan
Reviews for Cozaar (Losartan)
57%
of people say Cozaar (Losartan) is worth it
47%
say it works well
16%
say it's a big hassle
Reviews for Zestril (Lisinopril)
61%
+4% vs. Cozaar (Losartan)
51%
+4% vs. Cozaar (Losartan)
13%
+3% vs. Cozaar (Losartan)
Side effects
LosartanLisinopril
  • Urinary tract infection 6%
  • Diarrhea 5%
  • Low blood sugar 4%
  • Low blood pressure 4%
  • Muscle weakness/fatiguea/fatigue 4%
  • Hyperkalemia 4%
  • Chest pain 4%
  • Low red blood cells 3%
  • Muscular weakness 3%
  • Orthostatic hypotension 3%
More Losartan side effects »
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »
How it works
LosartanLisinopril
Cozaar (Losartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
LosartanLisinopril
Antihypertensive
Angiotensin receptor blocker
Prescription only
Antihypertensive
ACE inhibitor
Prescription only
Available as
LosartanLisinopril
  • Pill
  • Pill
Used for (click to learn more)
LosartanLisinopril
Risk factors for serious side effects
LosartanLisinopril
  • Women of childbearing age
  • Concurrent liver disease
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
Detailed Cozaar (Losartan) risks & warnings »
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
    Pregnancy category
    LosartanLisinopril
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    LosartanLisinopril
    • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    Downsides and risks
    LosartanLisinopril
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    Tips from our pharmacists for people taking the medication
    LosartanLisinopril
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    Learn more
    More about LosartanSide effectsReviews & ratingsAlternativesFDA package insert
    More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert