Compare Losartan vs. Nifedipine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cozaar
(losartan)

Procardia
(nifedipine)

Lowers blood pressure. Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.Lowers blood pressure and controls heart rate. Nifedipine works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding grapefruit. You can't miss doses, and you might get persistent swelling.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.99Losartan
Reviews for Losartan
57%
of people (All ages) say Losartan is worth it
48%
say it works well
16%
say it's a big hassle
535 reviews
Have you used Cozaar (losartan)?
Worth itNot sureNot worth it
Reviews for Nifedipine
42%
+15% better vs. Losartan
31%
+17% better vs. Losartan
46%
+30% better vs. Losartan
Have you used Procardia (nifedipine)?
Worth itNot sureNot worth it
Side effects
LosartanNifedipine
  • Upper respiratory infection 1%
  • Dizziness 1%
  • Back pain 1%
  • Nasal congestion 1%
  • Urinary tract infection 6%
  • Diarrhea 5%
  • Asthenia/Fatigue 4%
  • Anemia 3%
  • Hypoglycemia 4%
  • Back pain 2%
More Losartan side effects »
  • Dizziness, lightheadedness, giddiness 12%
  • Flushing 17%
  • Headache 3%
  • Weakness 2%
  • Nausea, heartburn 3%
  • Muscle cramps, tremor 5%
  • Peripheral edema 6%
  • Nervousness, mood changes 3%
  • Palpitation 2%
  • Dyspnea, cough, wheezing 3%
More Nifedipine side effects »
How it works
LosartanNifedipine
Cozaar (Losartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Nifedipine is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.
Type of medication
LosartanNifedipine
Prescription onlyPrescription only
Available as
LosartanNifedipine
  • Pill
  • Pill
  • Extended release
Used for
LosartanNifedipine
Risk factors for serious side effects
LosartanNifedipine
  • Women of childbearing age
  • Concurrent liver disease
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
Detailed Cozaar (losartan) risks & warnings »
  • Taking anti-inflammatories, acid reducers in the stomach, anticholinergics, laxatives, levothyroxine
  • History of intestinal surgery
  • Taking beta-blockers
  • Severe coronary artery disease.
  • History of cirrhosis
Detailed Procardia (nifedipine) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
LosartanNifedipine
  • Requires routine blood tests to check kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Reports of liver damage have occurred while on this medication, especially if you have had cirrhosis. Your doctor will monitor your liver on a regular basis. Tell your doctor if you or your caregivers/family notice your skin or the whites of your eyes are becoming yellower, pain in your abdomen, or sudden confusion.
Upsides and benefits
LosartanNifedipine
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
Downsides and risks
LosartanNifedipine
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Nifedipine than men.
  • You can't miss doses. Stopping Nifedipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Not a good medication for you if you love grapefruit. It can make Nifedipine have a stronger effect on your blood pressure.
Tips from our pharmacists for people taking the medication
LosartanNifedipine
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
  • Can cause dizziness or headaches in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause face flushing and ankle or foot swelling.
  • Avoid grapefruit while taking this medicine.
  • Your doctor might do routine blood tests to check your liver function.
Learn more
More about LosartanSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cozaar (losartan)?
Worth itNot sureNot worth it
More about NifedipineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Procardia (nifedipine)?
Worth itNot sureNot worth it