Compare Lovastatin vs. Vytorin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mevacor
(Lovastatin)

Vytorin
(Ezetimibe / Simvastatin)

Lowers cholesterol. Mevacor (Lovastatin) can improve cholesterol, but it's not as strong as other statin medicines. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks.Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.54Lovastatin
Reviews for Mevacor (Lovastatin)
43%
of people (All ages) say Mevacor (Lovastatin) is worth it
39%
say it works well
22%
say it's a big hassle
Have you used Mevacor (Lovastatin)?
Worth itNot sureNot worth it
Reviews for Vytorin (Ezetimibe / Simvastatin)
53%
+10% vs. Mevacor (Lovastatin)
36%
3% vs. Mevacor (Lovastatin)
19%
+3% vs. Mevacor (Lovastatin)
Have you used Vytorin (Ezetimibe / Simvastatin)?
Worth itNot sureNot worth it
Side effects
LovastatinVytorin
  • Constipation 2%
  • Passing gas 1%
  • Muscle weakness 1%
  • Abdominal pain 1%
  • Diarrhea 1%
  • Muscle pain 1%
More Lovastatin side effects »
  • Unexplained muscle pain or weakness 1%
More Vytorin side effects »
How it works
LovastatinVytorin
Mevacor (Lovastatin) is cholesterol-lowering medicine called a statin. It lowers the amount of cholesterol your body makes, which helps lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL).Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.
Type of medication
LovastatinVytorin
Cholesterol-lowering
Statin
Prescription only
Cholesterol-lowering
Cholesterol inhibitor
Statin
Prescription only
Available as
LovastatinVytorin
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
LovastatinVytorin
Risk factors for serious side effects
LovastatinVytorin
  • Kidney disease
  • High dose of Mevacor (Lovastatin)
  • Combining with certain cholesterol-lowering drugs
  • Older age and female gender
  • Heavy alcohol use
Detailed risks & warnings »
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
  • Pregnancy
Detailed risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Interactions
LovastatinVytorin
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
No interactions related info.
Alcohol
LovastatinVytorin
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
No alcohol related info.
Food
LovastatinVytorin
  • Works best if you take it once a day after your evening meal.
No food related info.
Kidneys and liver
LovastatinVytorin
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • There are rare cases of muscle damage leading to kidney failure in people taking Mevacor (Lovastatin). The risk is greater in people with kidney disease or thyroid disease, are older and female and taking certain cholesterol-lowering medication combinations. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no known cause.
  • There are reports of liver damage in people who take Mevacor (Lovastatin), especially if they are heavy alcohol drinkers or have a history of liver disease. If you notice dark urine or yellowing of the eyes or skin, tell your doctor. Your doctor may also want to check your liver function periodically.
  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
Pain
LovastatinVytorin
  • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis) and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
No pain related info.
Upsides and benefits
LovastatinVytorin
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
Downsides and risks
LovastatinVytorin
  • Not the best choice for people who have very high cholesterol levels.
  • Statins can cause digestive problems, blood sugar problems, muscle aches and stiffness, muscle injury, kidney damage, and liver damage. Some people have to stop taking this medicine because of these problems.
  • You're at higher risk for these side effects if you are female, are 65 years or older, drink alcohol every day, take more than one medicine for cholesterol, or have liver disease, kidney disease, or diabetes.
  • Not safe to use if you're pregnant.
  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.
Tips from our pharmacists for people taking the medication
LovastatinVytorin
  • Lowers bad cholesterol and triglycerides, and raises good cholesterol.
  • Most people reach their target cholesterol levels in 4 to 6 weeks.
  • Works best if you take it once a day after your evening meal.
  • Tell your doctor if you develop sudden muscle pain, fever, or weakness.
  • Tell your doctor if you notice dark urine or yellowing of the eyes or skin.
  • Certain medications can interact with this drug. Talk to your doctor or pharmacist.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Take it in the evening.
  • Can cause headaches or diarrhea.
  • Call your doctor if you develop muscle pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
Learn more
More about LovastatinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Mevacor (Lovastatin)?
Worth itNot sureNot worth it
More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vytorin (Ezetimibe / Simvastatin)?
Worth itNot sureNot worth it