Compare Lovenox vs. Eliquis

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lovenox
(Enoxaparin)

Eliquis
(apixaban)

Prevents blood clots. Lovenox (Enoxaparin) is a good anticoagulant that reduces the risk of death or bleeding, and blood clots are less likely to happen. However, it is only available as an injection which isn't great if you're afraid of needles.Prevents blood clots. Eliquis (apixaban) is an effective way to prevent blood clots from forming in your veins, but you have to take it twice a day, and your doctor might have to change the dose a lot.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.53Lovenox
Reviews for Lovenox
63%
of people (All ages) say Lovenox is worth it
63%
say it works well
16%
say it's a big hassle
Have you used Lovenox (Enoxaparin)?
Worth itNot sureNot worth it
Reviews for Eliquis
47%
+16% better vs. Lovenox
58%
+5% better vs. Lovenox
21%
+5% better vs. Lovenox
Have you used Eliquis (apixaban)?
Worth itNot sureNot worth it
Side effects
LovenoxEliquis
  • Major hemorrhage 2%
  • Confusion 1%
  • Nausea 1%
  • Hemorrhage 5%
  • Injection site hematoma 7%
More Lovenox side effects »
  • Major bleed 2%
  • Bleeding 12%
  • Nausea 3%
  • Anemia 3%
  • Severe bruising 2%
  • Blood in the urine 2%
  • Nose bleeding 3%
  • All bleeding 15%
  • Blood clots 1%
  • Nosebleeds 3%
More Eliquis side effects »
How it works
LovenoxEliquis
Lovenox (Enoxaparin) is an anticoagulant that prevents certain blood-clotting proteins from working. By stopping blood clots from forming, there's a lower chance of having a stroke or blood clots travel to your lungs.Eliquis (apixaban) is a factor Xa inhibitor anticoagulant that stops the formation of blood clots in your body so you're less likely to have a stroke or heart attack.
Type of medication
LovenoxEliquis
Prescription onlyLower-cost generic availablePrescription onlyNo lower cost generic available
Available as
LovenoxEliquis
  • Injection
  • Pill
Used for
LovenoxEliquis
Risk factors for serious side effects
LovenoxEliquis
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • Taking NSAIDs or other blood thinning medicines
  • History of bleeding problems
  • Severe high blood pressure
Detailed Lovenox (Enoxaparin) risks & warnings »
  • Stopping Eliquis (apixaban) prematurely
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of spinal surgery
  • Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs), or other blood-thinners
Detailed Eliquis (apixaban) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
LovenoxEliquis
No interactions related info.
  • Eliquis (apixaban) can interact with different medicines. Make sure your doctor and pharmacist know all the medicines you're taking.
Food
LovenoxEliquis
  • Available in generic so it can be cheaper than other "blood thinners".
  • Take twice a day, with or without food, at the same time each day.
Kidneys and liver
LovenoxEliquis
No kidneys and liver related info.
  • Eliquis (apixaban) is broken down by the kidney and liver. If you already have problems with your kidney or liver, talk to your doctor to make sure Eliquis (apixaban) is right for you.
Upsides and benefits
LovenoxEliquis
  • In a study that compared Lovenox (Enoxaparin) to other medications used to stop blood clots, there was a lower risk of clots coming back, with similar rates of major bleeding and mortality.
  • You don't need to go in for lab tests to check whether it's working, unlike other medications like warfarin that require regular blood draws.
  • Available in generic so it can be cheaper than other "blood thinners".
  • Good option if you're pregnant or have cancer.
  • Eliquis (apixaban) is very effective in reducing the risk of stroke in people with atrial fibrilation or other clotting disorders.
  • You don't need to have regular blood tests on Eliquis (apixaban), and you don't have to regulate your diet like other blood thinners.
  • If you've had clots in your legs or lungs before, Eliquis (apixaban) can lower the risk of these forming again.
Downsides and risks
LovenoxEliquis
  • It is only available as an injection, so it's not great if you're afraid of needles.
  • While surprise bleeding episodes can be treated while taking Lovenox (Enoxaparin), they won't completely work.
  • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
  • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or bloody stools.
  • Can't be used if you have artificial heart valves.
  • Never stop taking Eliquis (apixaban) without talking to your doctor first.
  • Eliquis (apixaban) isn't available as a generic, so it can be expensive.
  • If you've taken too much Eliquis (apixaban) and you're bleeding, it can be harder to treat compared to other blood thinners.
Tips from our pharmacists for people taking the medication
LovenoxEliquis
  • Rotate the spot where you inject Lovenox (Enoxaparin) every day.
  • While on this, it can take longer to stop bleeding and you are more likely to bruise or bleed more easily.
  • Avoid taking certain anti-inflammatory drugs (like NSAIDs) because they can make you more likely to bleed.
  • Can cause swelling in your legs, diarrhea, and nausea.
  • Take twice a day, with or without food, at the same time each day.
  • If you're going to have a dental procedure or surgery, make sure your dentist or surgeon talks to your doctor first.
  • You can bruise easier while taking Eliquis (apixaban) and if you have a cut, it can take longer for bleeding to stop.
  • Eliquis (apixaban) can interact with different medicines. Make sure your doctor and pharmacist know all the medicines you're taking.
  • Call a doctor immediately if you have dizziness, weakness, or a really bad headache.
Learn more
More about LovenoxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lovenox (Enoxaparin)?
Worth itNot sureNot worth it
More about EliquisSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Eliquis (apixaban)?
Worth itNot sureNot worth it