Compare Lovenox vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lovenox
(enoxaparin)

Xarelto
(rivaroxaban)

Prevents blood clots. Lovenox (Enoxaparin) is a good anticoagulant that reduces the risk of death or bleeding, and blood clots are less likely to happen. However, it is only available as an injection which isn't great if you're afraid of needles.Prevents blood clots. Xarelto (rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.53Lovenox
Reviews for Lovenox
63%
of people (All ages) say Lovenox is worth it
63%
say it works well
16%
say it's a big hassle
Have you used Lovenox (enoxaparin)?
Worth itNot sureNot worth it
Reviews for Xarelto
45%
+18% better vs. Lovenox
45%
+18% better vs. Lovenox
9%
-7% worse vs. Lovenox
Have you used Xarelto (rivaroxaban)?
Worth itNot sureNot worth it
Side effects
LovenoxXarelto
  • Injection site hematoma 7%
  • Hemorrhage 7%
  • Major hemorrhage 4%
  • Nausea 1%
  • Confusion 1%
  • Fever 2%
More Lovenox side effects »
  • Major bleeding needing transfusion 4%
  • Bleeding in the stomach & intestines 2%
  • Complaints of bleeding 28%
  • Clinically relevant but not major bleeding 9%
  • Back pain 3%
  • Upper abdominal pain 2%
  • Joint arthritis 1%
  • Any bleeding event after hip or knee replacement surgery 6%
  • Any side effect causing stopping of Xarelto (rivaroxaban) 4%
  • Wound drainage 3%
More Xarelto side effects »
How it works
LovenoxXarelto
Lovenox (Enoxaparin) is an anticoagulant that prevents certain blood-clotting proteins from working. By stopping blood clots from forming, there's a lower chance of having a stroke or blood clots travel to your lungs.Xarelto (rivaroxaban) is an anticoagulant that stops blood clots from forming.
Type of medication
LovenoxXarelto
Prescription onlyPrescription only
Available as
LovenoxXarelto
  • Injection
  • Pill
Used for
LovenoxXarelto
Risk factors for serious side effects
LovenoxXarelto
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • Taking NSAIDs or other blood thinning medicines
  • History of bleeding problems
  • Severe high blood pressure
Detailed Lovenox (enoxaparin) risks & warnings »
  • Stopping Xarelto (rivaroxaban) too soon
  • Artificial heart valve
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of bleeding problems
Detailed Xarelto (rivaroxaban) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
LovenoxXarelto
No interactions related info.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
Food
LovenoxXarelto
  • Available in generic so it can be cheaper than other "blood thinners".
  • Like all blood thinners, it will take a little longer for your blood to clot if you start bleeding while you're taking Xarelto (rivaroxaban). Call your doctor if you notice bleeding that won't stop, a bruise that won't go away or gets worse, pink or brown urine, bright red or dark tarry stool, nose bleeds, or if you start coughing up blood.
Kidneys and liver
LovenoxXarelto
No kidneys and liver related info.
  • Xarelto (rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to avoid other side effects.
Upsides and benefits
LovenoxXarelto
  • In a study that compared Lovenox (Enoxaparin) to other medications used to stop blood clots, there was a lower risk of clots coming back, with similar rates of major bleeding and mortality.
  • You don't need to go in for lab tests to check whether it's working, unlike other medications like warfarin that require regular blood draws.
  • Available in generic so it can be cheaper than other "blood thinners".
  • Good option if you're pregnant or have cancer.
  • Studies show that Xarelto (rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
  • Xarelto (rivaroxaban) doesn't require regular blood tests or frequent dose changes.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
Downsides and risks
LovenoxXarelto
  • It is only available as an injection, so it's not great if you're afraid of needles.
  • While surprise bleeding episodes can be treated while taking Lovenox (Enoxaparin), they won't completely work.
  • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
  • Xarelto (rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
  • Xarelto (rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (rivaroxaban).
  • You can't take Xarelto (rivaroxaban) if you are pregnant.
Tips from our pharmacists for people taking the medication
LovenoxXarelto
  • Rotate the spot where you inject Lovenox (Enoxaparin) every day.
  • While on this, it can take longer to stop bleeding and you are more likely to bruise or bleed more easily.
  • Avoid taking certain anti-inflammatory drugs (like NSAIDs) because they can make you more likely to bleed.
  • Can cause swelling in your legs, diarrhea, and nausea.
  • Xarelto (rivaroxaban) prevents blood from clotting, so it's important not to miss a dose. If you miss your daily dose, take it as soon as you remember that day. Just don't take two doses close to each other.
  • If you completely forget to take a dose, call your doctor right away.
  • When taking Xarelto (rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
  • You can crush the pills and mix it with a spoonful of applesauce, but make sure to eat some food and drink a glass of water right away.
Learn more
More about LovenoxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lovenox (enoxaparin)?
Worth itNot sureNot worth it
More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Xarelto (rivaroxaban)?
Worth itNot sureNot worth it