Compare loxapine vs. perphenazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Loxitane
(loxapine)

Trilafon
(perphenazine)

Treats schizophrenia. Loxitane (loxapine) is not recommended as a first choice medicine for treatment of schizophrenia, but it can be good if other medicines haven't worked because of bad side effects.Treats schizophrenia. Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.
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Coupons for loxapine
Best available price for 60 (10mg) capsules of loxapine
Coupons for perphenazine
Best available price for 30 (4mg) tablets of perphenazine
Reviews & ratings
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it
Side effects
loxapineperphenazine

The loxapine FDA package insert doesn’t have numbers about how common side effects are.

More about loxapine side effects »

The perphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about perphenazine side effects »
How it works
loxapineperphenazine
Loxitane (loxapine) is a typical antipsychotic. It works in the brain to calm down parts of the brain that might be responsible for aggressive behavior.Trilafon (perphenazine) works by blocking dopamine from entering the brain too quickly. Schizophrenia might be caused by your brain being too sensitive to changes in dopamine in your body.
Type of medication
loxapineperphenazine
Prescription onlyPrescription only
Available as
loxapineperphenazine
  • Pill
  • Pill
Used for
loxapineperphenazine
Risk factors for serious side effects
loxapineperphenazine
  • People age 65 and older with dementia and psychosis
  • Taking antipsychotic medications
  • History of seizures
Detailed Loxitane (loxapine) risks & warnings »
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol or taking narcotics
Detailed Trilafon (perphenazine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
loxapineperphenazine
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
Food
loxapineperphenazine
  • Take Loxitane (loxapine) with food to avoid stomach upset.
No food related info.
Sleep
loxapineperphenazine
No sleep related info.
  • Trilafon (perphenazine) can make you feel sleepy the first few days that you take it. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Trilafon (perphenazine) affects you.
Weight
loxapineperphenazine
No weight related info.
  • You're more likely to gain weight.
Upsides and benefits
loxapineperphenazine
  • Loxitane (loxapine) can be used to control schizophrenia if other medicines haven't worked because you don't like their side effects.
  • Loxitane (loxapine) is available as a generic.
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
Downsides and risks
loxapineperphenazine
  • Loxitane (loxapine) is not recommended as a first choice for treating schizophrenia because it's more likely to cause trouble with controlling movements.
  • Loxitane (loxapine) can stop vomiting, so it can be difficult to tell if someone's overdosed on drugs.
  • Loxitane (loxapine) can raise heart rate and lower blood pressure.
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
Tips from our pharmacists for people taking the medication
loxapineperphenazine
  • Take Loxitane (loxapine) with food to avoid stomach upset.
  • Don't drive or do anything requiring concentration until you know how Loxitane (loxapine) affects you since it can make you sleepy.
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
  • Be very careful getting up if you've been sitting or lying down for a while as Loxitane (loxapine) can cause changes in your blood pressure, which might make you more likely to faint or fall.
  • You might be more sensitive to the sun and heat while taking Trilafon (perphenazine). Use sunscreen if you have to go outside and drink plenty of liquids.
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Stopping Trilafon (perphenazine) suddenly can be very dangerous. Talk to your doctor if you want to stop taking it.
  • Don't drive or do anything that requires concentration until you know how Trilafon (perphenazine) affects you.
  • Take Trilafon (perphenazine) with food to avoid stomach upset.
Learn more
More about loxapineSide effectsAlternativesFDA package insert
Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it
More about perphenazineSide effectsAlternativesFDA package insert
Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it