Compare loxapine vs. Risperdal

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Loxitane (loxapine)

Prescription only

Risperdal (risperidone)

Prescription only
Treats schizophrenia.

Loxitane (loxapine) is not recommended as a first choice medicine for treatment of schizophrenia, but it can be good if other medicines haven't worked because of bad side effects.

Helps control your thoughts and mood.

Risperdal (risperidone) is an effective medication in treating schizophrenia, mania, and irritability associated with autism; however, amongst other newer medications in its class, it's more likely to cause side effects, such weight gain and hormone problems.

4.5/ 7 average rating with 45 reviewsforRisperdal
  • Loxitane (loxapine) can be used to control schizophrenia if other medicines haven't worked because you don't like their side effects.
  • Loxitane (loxapine) is available as a generic.
  • Risperdal (risperidone) is effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior. It also lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
  • Less likely to cause heart problems compared to other antipsychotics.
  • Compared to other antipsychotics, Risperdal (risperidone) causes less sedation and weight gain.
  • A generic version available for pill, dissolving tablet, and liquid formulations.
  • Loxitane (loxapine) is not recommended as a first choice for treating schizophrenia because it's more likely to cause trouble with controlling movements.
  • Loxitane (loxapine) can stop vomiting, so it can be difficult to tell if someone's overdosed on drugs.
  • Loxitane (loxapine) can raise heart rate and lower blood pressure.
  • Mild to moderate risk of Extrapyramidal Symptoms (EPS) - movement disorders that cause stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • People taking Risperdal (risperidone) might have weight gain and problems with cholesterol or blood sugar.
  • Compared to other antipsychotics, this medication has a higher risk of hormone problems that can cause nipples to leak and male breasts to grow abnormally large.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • Risperdal (risperidone) takes 4 to 6 weeks for its full effects on thoughts and mood.
Used for
Dosage forms
  • Pill
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
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Side effects
The Loxitane (loxapine) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Sedation
  • Increased appetite
  • Fatigue
  • Vomiting
  • Common cold
  • Constipation
  • Cough
  • Fever
  • Involuntary urination
  • Drooling
See more detailed side effects
Risks and warnings
  • Higher risk of death

    People age 65 and older with dementia and psychosis

  • Neuroleptic malignant syndrome

    Taking antipsychotic medications

  • Seizures

    History of seizures

See more detailed risks and warnings
  • Increased risk of death

    Elderly patients with dementia

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Shaking and restlessness

    High doses of Risperdal (risperidone)

  • Higher blood sugar and cholesterol and weight gain

    People with diabetes

    ...and 1 more risk factors

  • Driving impairment


    ...and 1 more risk factors

See more detailed risks and warnings