Compare loxapine vs. thioridazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Loxitane
(loxapine)

Mellaril
(thioridazine)

Treats schizophrenia. Loxitane (loxapine) is not recommended as a first choice medicine for treatment of schizophrenia, but it can be good if other medicines haven't worked because of bad side effects.Treats schizophrenia. Taking Mellaril (thioridazine) is one of many options to treat schizophrenia if other medicines haven't worked, but there are some side effects which can be dangerous.
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Coupons for loxapine
Best available price for 60 (10mg) capsules of loxapine
Reviews & ratings
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Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Mellaril (thioridazine)?
Worth itNot sureNot worth it
Side effects
loxapinethioridazine

The loxapine FDA package insert doesn’t have numbers about how common side effects are.

More about loxapine side effects »

The thioridazine FDA package insert doesn’t have numbers about how common side effects are.

More about thioridazine side effects »
How it works
loxapinethioridazine
Loxitane (loxapine) is a typical antipsychotic. It works in the brain to calm down parts of the brain that might be responsible for aggressive behavior.Mellaril (thioridazine) is a typical antipsychotic that lowers levels of dopamine in the brain. In schizophrenia, it's believed the brain produces too much dopamine.
Type of medication
loxapinethioridazine
Prescription onlyPrescription only
Available as
loxapinethioridazine
  • Pill
  • Pill
Used for
loxapinethioridazine
Risk factors for serious side effects
loxapinethioridazine
  • People age 65 and older with dementia and psychosis
  • Taking antipsychotic medications
  • History of seizures
Detailed Loxitane (loxapine) risks & warnings »
  • History of heartbeat problems
  • Taking medicines for depression
  • Taking beta blockers
  • People older than 65 years with dementia and psychosis
  • Long-term use of Mellaril (thioridazine)
Detailed Mellaril (thioridazine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
loxapinethioridazine
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
  • Don't drink alcohol while taking Mellaril (thioridazine).
Food
loxapinethioridazine
  • Take Loxitane (loxapine) with food to avoid stomach upset.
  • You can take Mellaril (thioridazine) with or without food. Take it with food if you get an upset stomach.
Sleep
loxapinethioridazine
No sleep related info.
  • Mellaril (thioridazine) can make you feel sleepy the first few days that you take it, and you might be more likely to fall and hurt yourself. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Mellaril (thioridazine) affects you. Be very careful getting up if you've been sitting or lying down for a while, and brace yourself and sit down if you do feel dizzy.
Upsides and benefits
loxapinethioridazine
  • Loxitane (loxapine) can be used to control schizophrenia if other medicines haven't worked because you don't like their side effects.
  • Loxitane (loxapine) is available as a generic.
  • Available in generic.
  • Compared to other similar medicines, Mellaril (thioridazine) is less likely to cause problems controlling your movements.
Downsides and risks
loxapinethioridazine
  • Loxitane (loxapine) is not recommended as a first choice for treating schizophrenia because it's more likely to cause trouble with controlling movements.
  • Loxitane (loxapine) can stop vomiting, so it can be difficult to tell if someone's overdosed on drugs.
  • Loxitane (loxapine) can raise heart rate and lower blood pressure.
  • Mellaril (thioridazine) is only recommended for schizophrenia if other medicines haven't worked because the side effects can be very dangerous.
  • You have to take Mellaril (thioridazine) numerous times a day which can make it hard to remember.
  • Mellaril (thioridazine) can interfere with your heartbeat, so your doctor might have you do annual tests with your heart to make sure it's healthy.
Tips from our pharmacists for people taking the medication
loxapinethioridazine
  • Take Loxitane (loxapine) with food to avoid stomach upset.
  • Don't drive or do anything requiring concentration until you know how Loxitane (loxapine) affects you since it can make you sleepy.
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
  • Be very careful getting up if you've been sitting or lying down for a while as Loxitane (loxapine) can cause changes in your blood pressure, which might make you more likely to faint or fall.
  • Don't stop taking Mellaril (thioridazine) suddenly without talking to your doctor, even if you start to feel well.
  • You can take Mellaril (thioridazine) with or without food. Take it with food if you get an upset stomach.
  • If you've missed a dose of Mellaril (thioridazine), take it as soon as you remember. But if it's time for your next dose, just take your normal amount and don't take extra medicine to make up for the missed dose.
  • Don't drive or do anything requiring concentration until you know how Mellaril (thioridazine) affects you.
  • Don't drink alcohol while taking Mellaril (thioridazine).
Learn more
More about loxapineSide effectsAlternativesFDA package insert
Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it
More about thioridazineSide effectsAlternativesFDA package insert
Have you used Mellaril (thioridazine)?
Worth itNot sureNot worth it