Compare loxapine vs. thiothixene

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Loxitane (loxapine)

Prescription only

Navane (thiothixene)

Prescription only
Treats schizophrenia.

Loxitane (loxapine) is not recommended as a first choice medicine for treatment of schizophrenia, but it can be good if other medicines haven't worked because of bad side effects.

Treats schizophrenia.

Navane (thiothixene) isn't a first choice for treating schizophrenia because of the side effects, but it is cheaper than other medicines.

Upsides
  • Loxitane (loxapine) can be used to control schizophrenia if other medicines haven't worked because you don't like their side effects.
  • Loxitane (loxapine) is available as a generic.
  • Navane (thiothixene) is available in generic.
  • Navane (thiothixene) is less likely to make you sleepy.
Downsides
  • Loxitane (loxapine) is not recommended as a first choice for treating schizophrenia because it's more likely to cause trouble with controlling movements.
  • Loxitane (loxapine) can stop vomiting, so it can be difficult to tell if someone's overdosed on drugs.
  • Loxitane (loxapine) can raise heart rate and lower blood pressure.
  • Side effects include weight gain and high blood sugar.
  • Navane (thiothixene) can cause low blood pressure, which can cause fainting or falls if you’re not careful.
  • Smoking tobacco can make Navane (thiothixene) work poorly.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$17.55
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Lowest price near you
$29.28
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Reviews
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Side effects
The Loxitane (loxapine) FDA package insert doesn’t have numbers about how common side effects are.
The Navane (thiothixene) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Higher risk of death

    People age 65 and older with dementia and psychosis

  • Neuroleptic malignant syndrome

    Taking antipsychotic medications

  • Seizures

    History of seizures

See more detailed risks and warnings
  • Higher risk of death

    People age 65 or older with dementia and psychosis

  • Drowsiness and sleepiness

    Drinking alcohol, or taking opioids, benzodiazepines, or sleeping medicines

See more detailed risks and warnings