Compare loxapine vs. thiothixene

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Loxitane
(loxapine)

Navane
(thiothixene)

Treats schizophrenia. Loxitane (loxapine) is not recommended as a first choice medicine for treatment of schizophrenia, but it can be good if other medicines haven't worked because of bad side effects.Treats schizophrenia. Navane (thiothixene) isn't a first choice for treating schizophrenia because of the side effects, but it is cheaper than other medicines.
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Coupons for loxapine
Best available price for 60 (10mg) capsules of loxapine
Coupons for thiothixene
Best available price for 30 (5mg) capsules of thiothixene
Reviews & ratings
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Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Navane (thiothixene)?
Worth itNot sureNot worth it
Side effects
loxapinethiothixene

The loxapine FDA package insert doesn’t have numbers about how common side effects are.

More about loxapine side effects »

The thiothixene FDA package insert doesn’t have numbers about how common side effects are.

More about thiothixene side effects »
How it works
loxapinethiothixene
Loxitane (loxapine) is a typical antipsychotic. It works in the brain to calm down parts of the brain that might be responsible for aggressive behavior.Navane (thiothixene) is a typical antipsychotic. It works by lowering levels of dopamine in the brain. It's believed that schizophrenia might be caused by the brain being too sensitive to changes in dopamine.
Type of medication
loxapinethiothixene
Prescription onlyPrescription only
Available as
loxapinethiothixene
  • Pill
  • Pill
Used for
loxapinethiothixene
Risk factors for serious side effects
loxapinethiothixene
  • People age 65 and older with dementia and psychosis
  • Taking antipsychotic medications
  • History of seizures
Detailed Loxitane (loxapine) risks & warnings »
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol, or taking opioids, benzodiazepines, or sleeping medicines
Detailed Navane (thiothixene) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
loxapinethiothixene
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
  • Don't drink alcohol while taking Navane (thiothixene).
Food
loxapinethiothixene
  • Take Loxitane (loxapine) with food to avoid stomach upset.
  • Take Navane (thiothixene) with food so you don't get an upset stomach.
Sleep
loxapinethiothixene
No sleep related info.
  • Navane (thiothixene) can make you sleepy and unable to focus, so don't drive or do anything requiring concentration for a few hours after taking it until you know how Navane (thiothixene) affects your concentration. This can be worse if you drink alcohol or take medicines that can make you sleepy, such as opioids for pain, benzodiazepines for anxiety, or medicines to help you sleep.
Weight
loxapinethiothixene
No weight related info.
  • Side effects include weight gain and high blood sugar.
Upsides and benefits
loxapinethiothixene
  • Loxitane (loxapine) can be used to control schizophrenia if other medicines haven't worked because you don't like their side effects.
  • Loxitane (loxapine) is available as a generic.
  • Navane (thiothixene) is available in generic.
  • Navane (thiothixene) is less likely to make you sleepy.
Downsides and risks
loxapinethiothixene
  • Loxitane (loxapine) is not recommended as a first choice for treating schizophrenia because it's more likely to cause trouble with controlling movements.
  • Loxitane (loxapine) can stop vomiting, so it can be difficult to tell if someone's overdosed on drugs.
  • Loxitane (loxapine) can raise heart rate and lower blood pressure.
  • Side effects include weight gain and high blood sugar.
  • Navane (thiothixene) can cause low blood pressure, which can cause fainting or falls if you’re not careful.
  • Smoking tobacco can make Navane (thiothixene) work poorly.
Tips from our pharmacists for people taking the medication
loxapinethiothixene
  • Take Loxitane (loxapine) with food to avoid stomach upset.
  • Don't drive or do anything requiring concentration until you know how Loxitane (loxapine) affects you since it can make you sleepy.
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
  • Be very careful getting up if you've been sitting or lying down for a while as Loxitane (loxapine) can cause changes in your blood pressure, which might make you more likely to faint or fall.
  • Don't drive or do anything requiring concentration until you know how Navane (thiothixene) affects you.
  • You might not notice any changes in your behavior until you've taken Navane (thiothixene) for at least 4 weeks.
  • Navane (thiothixene) can cause low blood pressure. Be very careful getting up if you've been sitting or lying down for a while since you can feel faint.
  • Navane (thiothixene) can make it hard to control your body temperature. Be careful exercising, especially in the heat, and dress warmly if it's cold.
  • Take Navane (thiothixene) with food so you don't get an upset stomach.
  • Don't drink alcohol while taking Navane (thiothixene).
Learn more
More about loxapineSide effectsAlternativesFDA package insert
Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it
More about thiothixeneSide effectsAlternativesFDA package insert
Have you used Navane (thiothixene)?
Worth itNot sureNot worth it