Compare Lunesta vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lunesta (Eszopiclone)

Prescription only

Zonalon (Doxepin)

Prescription only
Helps you sleep.

Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.

4.5/ 7 average rating with 592 reviewsforLunesta
Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Upsides
  • Effective at helping people fall asleep faster and sleep longer.
  • Not as habit-forming, so you can use it for longer than most other sleep medicines.
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
Downsides
  • More likely to cause withdrawal symptoms if you stop taking it suddenly.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
  • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
Used for
  • Skin intching (moderate)
Dosage forms
  • Pill
  • Cream, gel, or ointment
Price
Lowest price near you
$22.82
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Lowest price near you
$9.99
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Reviews
592 
55%
think this treatment is worth it
36%
think this treatment works well
17%
think this treatment is a hassle

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Side effects
10possible side effects
  • Headache
    15%
  • Unpleasant Taste
    8%
  • Dyspepsia
    6%
  • Pain
    4%
  • Diarrhea
    4%
  • Pruritus
    4%
  • Dry Mouth
    3%
  • Abnormal Dreams
    3%
  • Neuralgia
    3%
  • Urinary Tract Infection
    3%
See more detailed side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Dependence and withdrawal

    Continuous use for 2 weeks or more

  • Driving impairment

    Alcohol

    ...and 2 more risk factors

  • Abnormal thoughts

    Undiagnosed psychiatric conditions

  • Sleep driving

    Taking with alcohol or drugs that acts in the brain

  • Risk of falls and injury

    Elderly

    ...and 4 more risk factors

  • Risk to fetus

    Women of childbearing age

    ...and 1 more risk factors

See more detailed risks and warnings