Compare Lunesta vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lunesta
(eszopiclone)

Zonalon
(doxepin)

Helps you sleep. Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.
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Coupons for Lunesta
Best available price for 30 (3mg) tablets of lunesta
Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.47Lunesta
Reviews for Lunesta
55%
of people (All ages) say Lunesta is worth it
36%
say it works well
17%
say it's a big hassle
592 reviews
Have you used Lunesta (eszopiclone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it
Side effects
LunestaDoxepin
  • Headache 8%
  • Unpleasant taste 14%
  • Drowsiness 7%
  • Dizziness 1%
  • Nausea 1%
  • Infection 2%
  • Dry mouth 2%
  • Nervousness 2%
  • Low mood disorder 4%
More Lunesta side effects »

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »
How it works
LunestaDoxepin
Lunesta (Eszopiclone) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.
Type of medication
LunestaDoxepin
Prescription onlyPrescription only
Available as
LunestaDoxepin
  • Pill
  • Cream, gel, or ointment
Used for
LunestaDoxepin
  • Skin Intching Moderate
Risk factors for serious side effects
LunestaDoxepin
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep.
  • Undiagnosed psychiatric conditions
Detailed Lunesta (eszopiclone) risks & warnings »
    Detailed Zonalon (doxepin) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Price
    LunestaDoxepin
    No price related info.
    • It isn't available as a generic, so it could be kind of pricey.
    Interactions
    LunestaDoxepin
    No interactions related info.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Alcohol
    LunestaDoxepin
    • Avoid alcohol and drugs.
    • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
    No alcohol related info.
    Sleep
    LunestaDoxepin
    • Lunesta (Eszopiclone) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Lunesta (Eszopiclone) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
    • Only take it if you have time to sleep for at least 7 hours.
    • Can cause headache, drowsiness, and dizziness.
    • Effective at helping people fall asleep faster and sleep longer.
    • Zonalon (Doxepin) can make you sleepy.
    Upsides and benefits
    LunestaDoxepin
    • Effective at helping people fall asleep faster and sleep longer.
    • Not as habit-forming, so you can use it for longer than most other sleep medicines.
    • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
    • You can use Zonalon (Doxepin) for up to 8 days at a time.
    Downsides and risks
    LunestaDoxepin
    • More likely to cause withdrawal symptoms if you stop taking it suddenly.
    • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
    • You need a prescription for Zonalon (Doxepin).
    • It isn't available as a generic, so it could be kind of pricey.
    • Zonalon (Doxepin) can make you sleepy.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Tips from our pharmacists for people taking the medication
    LunestaDoxepin
    • Take 30 to 45 minutes before bedtime.
    • Only take it if you have time to sleep for at least 7 hours.
    • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
    • Can cause headache, drowsiness, and dizziness.
    • Can cause sleep-walking, sleep-driving, and sleep-eating.
    • Works best if taken without food.
    • Avoid alcohol and drugs.
    • Withdrawal symptoms usually resolve in 1 to 2 nights.
    • Report any confusion or changes in thoughts or behavior.
    • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
    • Wash your hands before and after using it.
    • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
    • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
    • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
    Learn more
    More about LunestaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Lunesta (eszopiclone)?
    Worth itNot sureNot worth it
    More about DoxepinSide effectsFDA package insert
    Have you used Zonalon (doxepin)?
    Worth itNot sureNot worth it