Compare Lunesta vs. Hetlioz

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lunesta
(eszopiclone)

Hetlioz
(tasimelteon)

Helps you sleep. Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.Keeps the sleep cycle normal for completely blind people who aren't able to see light. Hetlioz (tasimelteon) is the only approved medicine to help completely blind people who are unable to see light maintain regular sleep cycles. It is only available as a brand name, so it can be expensive.
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Coupons for Lunesta
Best available price for 30 (3mg) tablets of lunesta
Coupons for Hetlioz
Best available price for 30 (20mg) capsules of hetlioz
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.47Lunesta
Reviews for Lunesta
55%
of people (All ages) say Lunesta is worth it
36%
say it works well
17%
say it's a big hassle
592 reviews
Have you used Lunesta (eszopiclone)?
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Have you used Hetlioz (tasimelteon)?
Worth itNot sureNot worth it
Side effects
LunestaHetlioz
  • Headache 8%
  • Unpleasant taste 14%
  • Drowsiness 7%
  • Dizziness 1%
  • Nausea 1%
  • Infection 2%
  • Dry mouth 2%
  • Nervousness 2%
  • Low mood disorder 4%
More Lunesta side effects »
  • Headache 10%
  • Abnormal liver tests 5%
  • Nightmares or abnormal dreams 10%
  • Common cold or flu 7%
  • Urinary tract infection 5%
More Hetlioz side effects »
How it works
LunestaHetlioz
Lunesta (Eszopiclone) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Hetlioz (tasimelteon) is a melatonin receptor agonist. It helps you to sleep at night and stay awake during the day.
Type of medication
LunestaHetlioz
Prescription onlyPrescription only
Available as
LunestaHetlioz
  • Pill
  • Pill
Used for
LunestaHetlioz
  • Non 24 Hour Sleep Wake Cycle
Risk factors for serious side effects
LunestaHetlioz
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep.
  • Undiagnosed psychiatric conditions
Detailed Lunesta (eszopiclone) risks & warnings »
    Detailed Hetlioz (tasimelteon) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    LunestaHetlioz
    • Avoid alcohol and drugs.
    • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
    No alcohol related info.
    Sleep
    LunestaHetlioz
    • Lunesta (Eszopiclone) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Lunesta (Eszopiclone) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
    • Only take it if you have time to sleep for at least 7 hours.
    • Can cause headache, drowsiness, and dizziness.
    • Effective at helping people fall asleep faster and sleep longer.
    • If you go to sleep at a different time, don't take Hetlioz (tasimelteon).
    Upsides and benefits
    LunestaHetlioz
    • Effective at helping people fall asleep faster and sleep longer.
    • Not as habit-forming, so you can use it for longer than most other sleep medicines.
    • Hetlioz (tasimelteon) is not addictive.
    • Hetlioz (tasimelteon) is the only drug that's approved to help people unable to see light to have regular sleep cycles.
    • If you have to stop taking Hetlioz (tasimelteon) suddenly, you're not likely to have withdrawal.
    Downsides and risks
    LunestaHetlioz
    • More likely to cause withdrawal symptoms if you stop taking it suddenly.
    • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
    • Hetlioz (tasimelteon) can take weeks to months for you to notice any effect.
    • Hetlioz (tasimelteon) is only available as a brand name so it can be expensive.
    Tips from our pharmacists for people taking the medication
    LunestaHetlioz
    • Take 30 to 45 minutes before bedtime.
    • Only take it if you have time to sleep for at least 7 hours.
    • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
    • Can cause headache, drowsiness, and dizziness.
    • Can cause sleep-walking, sleep-driving, and sleep-eating.
    • Works best if taken without food.
    • Avoid alcohol and drugs.
    • Withdrawal symptoms usually resolve in 1 to 2 nights.
    • Report any confusion or changes in thoughts or behavior.
    • Take Hetlioz (tasimelteon) at the same time every night.
    • Take Hetlioz (tasimelteon) on an empty stomach. Swallow capsule whole. Don't crush or chew the capsule.
    • If you go to sleep at a different time, don't take Hetlioz (tasimelteon).
    • Hetlioz (tasimelteon) might take weeks or months before you notice any effects.
    • If you smoke tobacco, Hetlioz (tasimelteon) might not work as well.
    Learn more
    More about LunestaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Lunesta (eszopiclone)?
    Worth itNot sureNot worth it
    More about HetliozSide effectsFDA package insert
    Have you used Hetlioz (tasimelteon)?
    Worth itNot sureNot worth it