Compare Lunesta vs. Klonopin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lunesta
(Eszopiclone)

Klonopin
(Clonazepam)

Helps you sleep. Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.Controls seizures and helps you relax. Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.439862542955327Lunesta
Reviews for Lunesta (Eszopiclone)
54%
of people say Lunesta (Eszopiclone) is worth it
35%
say it works well
17%
say it's a big hassle
Reviews for Klonopin (Clonazepam)
69%
+15% vs. Lunesta (Eszopiclone)
51%
+16% vs. Lunesta (Eszopiclone)
15%
+2% vs. Lunesta (Eszopiclone)
Side effects
LunestaKlonopin
  • Unpleasant taste 31%
  • Headache 8%
  • Drowsiness 7%
  • Infection 7%
  • Dry mouth 4%
  • Indigestion 4%
  • Dizziness 3%
  • Pain 3%
  • Rash 3%
  • Itching 3%
More Lunesta side effects »
  • Dizziness 8%
  • Low mood disorder 7%
  • Ear, nose, or throat infection 6%
  • Sinus inflammation 5%
  • Fatigue 5%
  • Menstrual cramps 4%
  • Memory disturbance 3%
  • Constipation 3%
  • Allergic reaction 3%
  • Vaginal inflammation 3%
More Klonopin side effects »
How it works
LunestaKlonopin
Lunesta (Eszopiclone) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Klonopin (Clonazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.
Type of medication
LunestaKlonopin
SedativePrescription only
Anti-anxiety
Benzodiazepine
Prescription only
Available as
LunestaKlonopin
  • Pill
  • Pill
  • Dissolving tablet
Used for (click to learn more)
LunestaKlonopin
Risk factors for serious side effects
LunestaKlonopin
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep.
  • Undiagnosed psychiatric conditions
  • Taking with alcohol or drugs that acts in the brain
    • Elderly
    • Higher dose
    • Liver problems
    • Taking Lunesta (Eszopiclone) with other nervous system depressants
    • Long-term use
    • Women of childbearing age
    • Breast-feeding
    Detailed Lunesta (Eszopiclone) risks & warnings »
    • Taking more than the prescribed dose
    • Taking longer than 4 weeks
    • History of drug abuse
    • Long-term use
      • Alcohol
      • Taking other medicines that make you less alert
        Detailed Klonopin (Clonazepam) risks & warnings »
        Pregnancy category
        LunestaKlonopin
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
        • Avoid alcohol and drugs.
        • Lunesta (Eszopiclone) can be disinhibiting (like alcohol) or cause hallucinations. Tell your doctor if you notice any unusual changes in behavior.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Not safe to use with alcohol.
        Food
        • Works best if taken without food.
        No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
        • Effective at helping people fall asleep faster and sleep longer.
        • Not as habit-forming, so you can use it for longer than most other sleep medicines.
        • Only take it if you have time to sleep for at least 7 hours.
        • Can cause headache, drowsiness, and dizziness.
        • Can cause sleep-walking, sleep-driving, and sleep-eating.
        • All prescription sleep-aid medicines like Lunesta (Eszopiclone) have a risk of physical dependence. Dependence means that you'll feel withdrawal symptoms if you stop taking the medication all at once. Talk to your doctor about natural ways to improve sleep or treat underlying conditions that prevent sleep.
        • Lunesta (Eszopiclone) increases your risk of performing potentially dangerous activities while asleep, such as sleep-walking, sleep-driving, and sleep-eating. Talk to your doctor immediately about stopping Lunesta (Eszopiclone) if any sleep-related activities occur.
        • Lunesta (Eszopiclone) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Lunesta (Eszopiclone) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can cause dizziness, drowsiness, and salivation.
        • Stopping Klonopin (Clonazepam) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and muscle pain or burning. Withdrawal symptoms can last 6 weeks or longer. Work with your doctor to gradually reduce your dose when stopping or switching to a different medication.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        LunestaKlonopin
        • Effective at helping people fall asleep faster and sleep longer.
        • Not as habit-forming, so you can use it for longer than most other sleep medicines.
        • Effective at relieving short-term anxiety and sleeplessness.
        • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
        • Can be used alone or with other medicines to treat seizures.
        • Less severe withdrawal symptoms compared to other benzodiazepines.
        Downsides and risks
        LunestaKlonopin
        • More likely to cause withdrawal symptoms if you stop taking it suddenly.
        • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
        • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Most people find that it gets less effective over time.
        Tips from our pharmacists for people taking the medication
        LunestaKlonopin
        • Take 30 to 45 minutes before bedtime.
        • Only take it if you have time to sleep for at least 7 hours.
        • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
        • Can cause headache, drowsiness, and dizziness.
        • Can cause sleep-walking, sleep-driving, and sleep-eating.
        • Works best if taken without food.
        • Avoid alcohol and drugs.
        • Withdrawal symptoms usually resolve in 1 to 2 nights.
        • Report any confusion or changes in thoughts or behavior.
        • For the first week, avoid activities that require you to be alert.
        • Can cause dizziness, drowsiness, and salivation.
        • Report any confusion or inability to control muscle movements to your doctor.
        • Not safe to use with alcohol.
        Learn more
        More about LunestaSide effectsReviews & ratingsAlternativesFDA package insert
        More about KlonopinSide effectsReviews & ratingsAlternativesFDA package insert