Compare Lunesta vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lunesta
(eszopiclone)

Remeron
(mirtazapine)

Helps you sleep. Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Coupons for Lunesta
Best available price for 30 (3mg) tablets of lunesta
Coupons for Remeron
Best available price for 30 (15mg) tablets of mirtazapine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.47Lunesta
Reviews for Lunesta
55%
of people (All ages) say Lunesta is worth it
36%
say it works well
17%
say it's a big hassle
592 reviews
Have you used Lunesta (eszopiclone)?
Worth itNot sureNot worth it
Reviews for Remeron
45%
+10% better vs. Lunesta
39%
-3% worse vs. Lunesta
26%
+9% better vs. Lunesta
152 reviews
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it
Side effects
LunestaRemeron
  • Headache 8%
  • Unpleasant taste 14%
  • Drowsiness 7%
  • Dizziness 1%
  • Nausea 1%
  • Infection 2%
  • Dry mouth 2%
  • Nervousness 2%
  • Low mood disorder 4%
More Lunesta side effects »
  • Drowsiness 36%
  • Dry mouth 10%
  • Increased appetite 15%
  • Constipation 6%
  • Weight gain 10%
  • Muscle weakness 3%
  • Dizziness 4%
  • Flu syndrome 2%
  • Abnormal dreams 3%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
LunestaRemeron
Lunesta (Eszopiclone) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
LunestaRemeron
Prescription onlyPrescription only
Available as
LunestaRemeron
  • Pill
  • Pill
  • Dissolving tablet
Used for
LunestaRemeron
Risk factors for serious side effects
LunestaRemeron
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep.
  • Undiagnosed psychiatric conditions
Detailed Lunesta (eszopiclone) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
Detailed Remeron (mirtazapine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
LunestaRemeron
  • Avoid alcohol and drugs.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
No alcohol related info.
Sleep
LunestaRemeron
  • Lunesta (Eszopiclone) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Lunesta (Eszopiclone) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
  • Only take it if you have time to sleep for at least 7 hours.
  • Can cause headache, drowsiness, and dizziness.
  • Effective at helping people fall asleep faster and sleep longer.
No sleep related info.
Weight
LunestaRemeron
No weight related info.
  • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
  • Can increase appetite and weight.
  • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
Upsides and benefits
LunestaRemeron
  • Effective at helping people fall asleep faster and sleep longer.
  • Not as habit-forming, so you can use it for longer than most other sleep medicines.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
  • Good option for people who are underweight or frail, because it can help you gain weight.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
LunestaRemeron
  • More likely to cause withdrawal symptoms if you stop taking it suddenly.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
  • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
LunestaRemeron
  • Take 30 to 45 minutes before bedtime.
  • Only take it if you have time to sleep for at least 7 hours.
  • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
  • Can cause headache, drowsiness, and dizziness.
  • Can cause sleep-walking, sleep-driving, and sleep-eating.
  • Works best if taken without food.
  • Avoid alcohol and drugs.
  • Withdrawal symptoms usually resolve in 1 to 2 nights.
  • Report any confusion or changes in thoughts or behavior.
  • Makes you sleepy. Take at bedtime.
  • Can increase appetite and weight.
  • Takes 8 to 12 weeks to see full effects on mood.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about LunestaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lunesta (eszopiclone)?
Worth itNot sureNot worth it
More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it