Compare Lunesta vs. Rozerem

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lunesta
(eszopiclone)

Rozerem
(ramelteon)

Helps you sleep. Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.Helps you fall asleep. Rozerem (ramelteon) is a good sleep medicine that's not addictive, but it can be expensive.
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Coupons for Lunesta
Best available price for 30 (3mg) tablets of eszopiclone
Coupons for Rozerem
Best available price for 30 (8mg) tablets of ramelteon
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.47Lunesta
Reviews for Lunesta (eszopiclone)
55%
of people (All ages) say Lunesta (eszopiclone) is worth it
36%
say it works well
17%
say it's a big hassle
592 reviews
Have you used Lunesta (eszopiclone)?
Worth itNot sureNot worth it
Reviews for Rozerem (ramelteon)
Not enough review data. Review it!
-55% worse vs. Lunesta (eszopiclone)
Not enough review data. Review it!
-36% worse vs. Lunesta (eszopiclone)
Not enough review data. Review it!
+17% better vs. Lunesta (eszopiclone)
Have you used Rozerem (ramelteon)?
Worth itNot sureNot worth it
Side effects
LunestaRozerem
  • Headache 8%
  • Unpleasant taste 14%
  • Drowsiness 7%
  • Dizziness 1%
  • Nausea 1%
  • Infection 2%
  • Dry mouth 2%
  • Nervousness 2%
  • Low mood disorder 4%
More Lunesta side effects »
  • Dizziness 1%
  • Sleepiness 1%
  • Fatigue 1%
  • Nausea 1%
  • Worsening insomnia 1%
More Rozerem side effects »
How it works
LunestaRozerem
Lunesta (Eszopiclone) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Rozerem (ramelteon) is a melatonin receptor agonist. Melatonin is a chemical the body uses to maintain a normal sleeping cycle; Rozerem (ramelteon) helps you fall asleep and stay asleep.
Type of medication
LunestaRozerem
Prescription only
Prescription only
Available as
LunestaRozerem
  • Pill
  • Pill
Used for
LunestaRozerem
Risk factors for serious side effects
LunestaRozerem
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep.
  • Undiagnosed psychiatric conditions
Detailed Lunesta (eszopiclone) risks & warnings »
  • Alcohol
  • Taking narcotics, tranquilizers, or antihistamines
Detailed Rozerem (ramelteon) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
LunestaRozerem
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
  • Avoid alcohol and drugs.
  • While taking Rozerem (ramelteon), don't drink alcohol or take other medicines that can make you sleepy, like opioids for pain relief, or benzodiazepines for anxiety.
Pain
LunestaRozerem
No pain related info.
  • If you’re taking Rozerem (ramelteon), you need to be very careful about drinking alcohol, or taking medicines such as narcotics for pain relief, tranquilizers for anxiety, or antihistamines. Taking Rozerem (ramelteon) with alcohol or these medicines can slow down your central nervous system to the point where you stop breathing. Talk to your doctor to see if you should change your other medicines while you take Rozerem (ramelteon).
Sleep
LunestaRozerem
  • Effective at helping people fall asleep faster and sleep longer.
  • Only take it if you have time to sleep for at least 7 hours.
  • Can cause headache, drowsiness, and dizziness.
  • Lunesta (Eszopiclone) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Lunesta (Eszopiclone) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
  • Don't take Rozerem (ramelteon) if you're not able to sleep for at least 8 hours.
  • If you're not sleeping better after taking Rozerem (ramelteon) for 7 to 10 days, talk to your doctor.
Upsides and benefits
LunestaRozerem
  • Effective at helping people fall asleep faster and sleep longer.
  • Not as habit-forming, so you can use it for longer than most other sleep medicines.
  • Rozerem (ramelteon) isn't a controlled medicine, and it's safe to use in people age 65 or older.
  • If you stop taking Rozerem (ramelteon) suddenly, your insomnia won't come back.
  • Rozerem (ramelteon) won't make you feel hungover or groggy the next day.
Downsides and risks
LunestaRozerem
  • More likely to cause withdrawal symptoms if you stop taking it suddenly.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
  • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
  • Rozerem (ramelteon) is only available as a brand name.
  • Rozerem (ramelteon) is only available in 1 strength.
  • If you take Rozerem (ramelteon) on a full stomach, it won't work as well.
  • Not recommended for children.
  • Rozerem (ramelteon) can't be used if you have sleep apnea.
Tips from our pharmacists for people taking the medication
LunestaRozerem
  • Take 30 to 45 minutes before bedtime.
  • Only take it if you have time to sleep for at least 7 hours.
  • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
  • Can cause headache, drowsiness, and dizziness.
  • Can cause sleep-walking, sleep-driving, and sleep-eating.
  • Works best if taken without food.
  • Avoid alcohol and drugs.
  • Withdrawal symptoms usually resolve in 1 to 2 nights.
  • Report any confusion or changes in thoughts or behavior.
  • Take Rozerem (ramelteon) on an empty stomach 30 minutes before you sleep.
  • Don't take Rozerem (ramelteon) if you're not able to sleep for at least 8 hours.
  • Swallow the Rozerem (ramelteon) tablet whole; don't break or crush it.
  • While taking Rozerem (ramelteon), don't drink alcohol or take other medicines that can make you sleepy, like opioids for pain relief, or benzodiazepines for anxiety.
  • If you're not sleeping better after taking Rozerem (ramelteon) for 7 to 10 days, talk to your doctor.
Learn more
More about LunestaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lunesta (eszopiclone)?
Worth itNot sureNot worth it
More about RozeremSide effectsAlternativesFDA package insert
Have you used Rozerem (ramelteon)?
Worth itNot sureNot worth it