Compare Lyrica vs. Cymbalta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lyrica
(pregabalin)

Cymbalta
(duloxetine)

Treats nerve pain and prevents seizures. Lyrica (Pregabalin) works well as an add-on medicine for seizures and fibromyalgia, but it's especially effective for nerve-related pain after shingles. Not available as a generic, so it might be expensive.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.39Lyrica
Reviews for Lyrica
47%
of people (All ages) say Lyrica is worth it
42%
say it works well
32%
say it's a big hassle
Have you used Lyrica (pregabalin)?
Worth itNot sureNot worth it
Reviews for Cymbalta
58%
-11% worse vs. Lyrica
49%
-7% worse vs. Lyrica
24%
-8% worse vs. Lyrica
496 reviews
Have you used Cymbalta (duloxetine)?
Worth itNot sureNot worth it
Side effects
LyricaCymbalta
  • Neuropathy 6%
  • Dizziness 3%
  • Ataxia 5%
  • Accidental injury 2%
  • Chest pain 3%
  • Peripheral edema 2%
  • Asthenia 2%
  • Somnolence 1%
  • Flatulence 2%
  • Dry mouth 2%
More Lyrica side effects »
  • Nausea 15%
  • Headache 2%
  • Dry mouth 8%
  • Somnolencee 7%
  • Fatigue 4%
  • Insomnia 4%
  • Constipation 5%
  • Dizziness 4%
  • Diarrhea 3%
  • Decreased appetite 5%
More Cymbalta side effects »
How it works
LyricaCymbalta
Lyrica (Pregabalin) is a nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.
Type of medication
LyricaCymbalta
Prescription onlyPrescription only
Available as
LyricaCymbalta
  • Pill
  • Liquid
  • Extended release
Used for
LyricaCymbalta
Risk factors for serious side effects
LyricaCymbalta
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of unusual swelling (angioedema)
  • Taking other medications that can angioedema
  • History of cardiovascular disease
Detailed Lyrica (pregabalin) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Cymbalta (Duloxetine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed Cymbalta (duloxetine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
LyricaCymbalta
  • Not available as a generic, so it can be pricey.
No price related info.
Alcohol
LyricaCymbalta
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
No alcohol related info.
Food
LyricaCymbalta
No food related info.
  • Take with food to avoid upset stomach.
Kidneys and liver
LyricaCymbalta
No kidneys and liver related info.
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
Pain
LyricaCymbalta
  • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
Sleep
LyricaCymbalta
  • Can make you drowsy or dizzy.
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
No sleep related info.
Upsides and benefits
LyricaCymbalta
  • Relieves nerve-related (neuropathic) pain caused by different conditions including diabetes, shingles (herpes zoster), fibromyalgia, and spinal cord damage.
  • Studies show that lower doses of Lyrica (Pregabalin) cause fewer side effects and still relieve pain just as well as higher doses.
  • Also used in combination with other medications to treat epilepsy (partial seizures).
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates for depression.
  • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
LyricaCymbalta
  • Not available as a generic, so it can be pricey.
  • You can't skip or miss doses since suddenly stopping Lyrica (Pregabalin) can cause seizures.
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
  • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
  • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
  • Not the best option for people with high blood pressure.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
LyricaCymbalta
  • Some people feel relief from pain in a week.
  • Can make you drowsy or dizzy.
  • Don't stop taking it suddenly without talking to your doctor. You'll need to slowly lower your dose over at least a week to avoid withdrawal symptoms.
  • Tell your doctor if you have unexplained confusion or changes in your thoughts or behavior.
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
  • Take with food to avoid upset stomach.
  • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about LyricaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lyrica (pregabalin)?
Worth itNot sureNot worth it
More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cymbalta (duloxetine)?
Worth itNot sureNot worth it