Compare Lyrica vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats pain caused by nerve damage and prevents seizures.

Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.

3.3/ 5 average rating with 66 reviewsforLyrica
Prevents seizures and stabilizes mood.

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

3.3/ 5 average rating with 97 reviewsforDepakote
Upsides
  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • It is less habit forming than narcotics.
  • It can also be used in combination with other anti-seizure medicines to treat epilepsy.
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
Downsides
  • Likely expensive since it is not available in generic versions.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Requires adjustment in dose if you have lower kidney function.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Price
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Reviews
66 reviews so far
47%
saidit'sworth it
42%
saiditworked well
32%
saidit'sa big hassle

Have you used Lyrica (pregabalin)?

Leave a review
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?

Leave a review
Side effects
28possible side effects
  • Dizziness
    23%
  • Drowsiness
    13%
  • Headache
    11%
  • Blurry vision
    8%
  • Weight gain
    8%
  • Dry mouth
    7%
  • Fatigue
    5%
  • Swelling of the hands and feet
    5%
  • Constipation
    4%
  • Sinus infection
    4%
  • Increased appetite
    4%
  • Joint pain
    4%
  • Loss of focus
    4%
  • Feeling off balance
    2%
  • Vomiting
    2%
  • Abdominal distension
    2%
  • Chest pain
    2%
  • Fluid retention
    2%
  • Muscle spasms
    2%
  • Back pain
    2%
  • Balance disorder
    2%
  • Abnormal coordination
    2%
  • Partial loss of sensitivity to touch
    2%
  • Lethargy
    2%
  • Intense feeling of happiness
    2%
  • Anxiety
    2%
  • Depression
    2%
  • Sore throat
    2%
See more detailed side effects
26possible side effects
  • Nausea
    48%
  • Headache
    31%
  • Asthenia
    27%
  • Vomiting
    27%
  • Somnolence
    27%
  • Tremor
    25%
  • Dizziness
    25%
  • Abdominal Pain
    23%
  • Diplopia
    16%
  • Diarrhea
    13%
  • Anorexia
    12%
  • Amblyopia/Blurred Vision
    12%
  • Flu Syndrome
    12%
  • Infection
    12%
  • Dyspepsia
    8%
  • Ataxia
    8%
  • Nystagmus
    8%
  • Fever
    6%
  • Emotional Lability
    6%
  • Thinking Abnormal
    6%
  • Alopecia
    6%
  • Weight Loss
    6%
  • Constipation
    5%
  • Amnesia
    5%
  • Bronchitis
    5%
  • Rhinitis
    5%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Starting Lyrica (pregabalin) or changing doses
  • Driving impairment
    • Taking Lyrica (pregabalin) with alcohol
    • Taking other medicines that make you drowsy
  • Giant hives (angioedema)
    • History of unusual swelling (angioedema)
    • Taking other medications (ie. lisinopril) that can cause angioedema
  • Heart problems
    • History of cardiovascular disease
  • Swelling of the hands and feet
    • Taking with certain diabetes medications
  • Withdrawal symptoms
    • Stopping Lyrica (pregabalin) suddenly
See more detailed risks and warnings
  • Pregnancy
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
  • Pancreatitis
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes due to high ammonia
    • History of metabolic disorders
    • People also taking Topamax
  • Low body temperature
    • People also taking Topamax
  • Serious allergic reactions
  • Withdrawal seizures
    • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
See more detailed risks and warnings