Compare Lyrica vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lyrica
(Pregabalin)

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Treats nerve pain and prevents seizures. Lyrica (Pregabalin) works well as an add-on medicine for seizures and fibromyalgia, but it's especially effective for nerve-related pain after shingles. Not available as a generic, so it might be expensive.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.380952380952381Lyrica
Reviews for Lyrica (Pregabalin)
46%
of people say Lyrica (Pregabalin) is worth it
41%
say it works well
32%
say it's a big hassle
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
Same vs. Lyrica (Pregabalin)
39%
2% vs. Lyrica (Pregabalin)
27%
+5% vs. Lyrica (Pregabalin)
Side effects
LyricaDepakote
  • Dizziness 36%
  • Nerve damage 34%
  • Drowsiness 24%
  • Lack of muscle coordination 24%
  • Weight gain 15%
  • Constipation 13%
  • Weight increased 12%
  • Dry mouth 12%
  • Leg or ankle swelling 12%
  • Vision blurred 11%
More Lyrica side effects »
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »
How it works
LyricaDepakote
Lyrica (Pregabalin) is a nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
LyricaDepakote
Anticonvulsant
GABA analog
Prescription only
AnticonvulsantPrescription only
Available as
LyricaDepakote
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for (click to learn more)
LyricaDepakote
Risk factors for serious side effects
LyricaDepakote
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • History of unusual swelling (angioedema)
    • Taking other medications that can angioedema
    • History of cardiovascular disease
    • Taking with certain diabetes medications
    • Stopping Lyrica (Pregabalin) suddenly
      • Both male and females taking Lyrica (Pregabalin)
      Detailed Lyrica (Pregabalin) risks & warnings »
        • Children under age 2
        • History of metabolic disorders
          • History of depression
            • History of metabolic disorders
            • People also taking Topamax
            • People also taking Topamax
              • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
              Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
              Pregnancy category
              LyricaDepakote
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
              No specific alcohol-related info.
              Food
              No specific food-related info.
              • Take with food to avoid upset stomach.
              Kidneys and liver
              • Some people taking Lyrica (Pregabalin) develop muscle damage leading to kidney failure (rhabdomyolysis), however, this is very rare. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no other related cause.
              No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
              • Can make you drowsy or dizzy.
              • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
              No specific sleep-related info.
              Weight
              No specific weight-related info.
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • May cause hair loss and weight gain.
              Upsides and benefits
              LyricaDepakote
              • Relieves nerve-related (neuropathic) pain caused by different conditions including diabetes, shingles (herpes zoster), fibromyalgia, and spinal cord damage.
              • Studies show that lower doses of Lyrica (Pregabalin) cause fewer side effects and still relieve pain just as well as higher doses.
              • Also used in combination with other medications to treat epilepsy (partial seizures).
              • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
              • One of the first-line options to stabilize mood for people with bipolar disorder.
              • Helpful in preventing frequent migraine headaches.
              Downsides and risks
              LyricaDepakote
              • Not available as a generic, so it can be pricey.
              • You can't skip or miss doses since suddenly stopping Lyrica (Pregabalin) can cause seizures.
              • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
              • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • Can cause liver damage, so it's probably not safe if you already have liver problems.
              • Not safe to use if you're pregnant.
              • Requires routine blood tests to see how the medicine is affecting your body.
              Tips from our pharmacists for people taking the medication
              LyricaDepakote
              • Some people feel relief from pain in a week.
              • Can make you drowsy or dizzy.
              • Don't stop taking it suddenly without talking to your doctor. You'll need to slowly lower your dose over at least a week to avoid withdrawal symptoms.
              • Tell your doctor if you have unexplained confusion or changes in your thoughts or behavior.
              • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Requires routine blood tests.
              • Take with food to avoid upset stomach.
              • May cause hair loss and weight gain.
              • Different versions of Depakote have different dosing. Be careful.
              • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
              • Takes 3 to 4 weeks to feel full effects on mood.
              Learn more
              More about LyricaSide effectsReviews & ratingsAlternativesFDA package insert
              More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert