Compare Lyrica vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lyrica
(pregabalin)

Depacon
(valproate, valproic acid, or divalproex)

Treats nerve pain and prevents seizures. Lyrica (Pregabalin) works well as an add-on medicine for seizures and fibromyalgia, but it's especially effective for nerve-related pain after shingles. Not available as a generic, so it might be expensive.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Coupons for Lyrica
Best available price for 60 (75mg) capsules of lyrica
Coupons for Depakote
Best available price for 60 (500mg) tablets of depakote
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.39Lyrica
Reviews for Lyrica
47%
of people (All ages) say Lyrica is worth it
42%
say it works well
32%
say it's a big hassle
Have you used Lyrica (pregabalin)?
Worth itNot sureNot worth it
Reviews for Depakote
46%
+1% better vs. Lyrica
40%
+2% better vs. Lyrica
27%
-5% worse vs. Lyrica
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
Side effects
LyricaDepakote
  • Nerve damage 6%
  • Dizziness 3%
  • Lack of muscle coordination 5%
  • Accidental injury 2%
  • Chest pain 3%
  • Leg or ankle swelling 2%
  • Muscle weakness 2%
  • Drowsiness 1%
  • Passing gas 2%
  • Dry mouth 2%
More Lyrica side effects »
  • Nausea 7%
  • Drowsiness 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Muscle weakness 3%
  • Abdominal pain 1%
  • Indigestion 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
How it works
LyricaDepakote
Lyrica (Pregabalin) is a nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
LyricaDepakote
Prescription onlyPrescription only
Available as
LyricaDepakote
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for
LyricaDepakote
Risk factors for serious side effects
LyricaDepakote
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of unusual swelling (angioedema)
  • Taking other medications that can angioedema
  • History of cardiovascular disease
Detailed Lyrica (pregabalin) risks & warnings »
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
LyricaDepakote
  • Not available as a generic, so it can be pricey.
No price related info.
Alcohol
LyricaDepakote
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
No alcohol related info.
Food
LyricaDepakote
No food related info.
  • Take with food to avoid upset stomach.
Kidneys and liver
LyricaDepakote
No kidneys and liver related info.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
Pain
LyricaDepakote
  • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
No pain related info.
Sleep
LyricaDepakote
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
  • Can make you drowsy or dizzy.
No sleep related info.
Weight
LyricaDepakote
No weight related info.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • May cause hair loss and weight gain.
Upsides and benefits
LyricaDepakote
  • Relieves nerve-related (neuropathic) pain caused by different conditions including diabetes, shingles (herpes zoster), fibromyalgia, and spinal cord damage.
  • Studies show that lower doses of Lyrica (Pregabalin) cause fewer side effects and still relieve pain just as well as higher doses.
  • Also used in combination with other medications to treat epilepsy (partial seizures).
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
Downsides and risks
LyricaDepakote
  • Not available as a generic, so it can be pricey.
  • You can't skip or miss doses since suddenly stopping Lyrica (Pregabalin) can cause seizures.
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
  • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Tips from our pharmacists for people taking the medication
LyricaDepakote
  • Some people feel relief from pain in a week.
  • Can make you drowsy or dizzy.
  • Don't stop taking it suddenly without talking to your doctor. You'll need to slowly lower your dose over at least a week to avoid withdrawal symptoms.
  • Tell your doctor if you have unexplained confusion or changes in your thoughts or behavior.
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
Learn more
More about LyricaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lyrica (pregabalin)?
Worth itNot sureNot worth it
More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it