Compare Lyrica vs. Lidocaine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lyrica (pregabalin)

Prescription only

Lidoderm (Lidocaine)

Prescription only
Treats pain caused by nerve damage and prevents seizures.

Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.

3.3/ 5 average rating with 66 reviewsforLyrica
Treats nerve pain.

Lidoderm (Lidocaine) patches work well by releasing a local anesthetic into the skin and relieving pain by targeting damaged nerves.

4.2/ 5 average rating with 18 reviewsforLidocaine
Upsides
  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • It is less habit forming than narcotics.
  • It can also be used in combination with other anti-seizure medicines to treat epilepsy.
  • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
  • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
  • Patches can be cut into smaller pieces to best fit the areas of skin they need to be used on.
Downsides
  • Likely expensive since it is not available in generic versions.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Requires adjustment in dose if you have lower kidney function.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
  • Can cause skin irritation after using it the first time, but for most people it's mild and goes away in a few minutes or hours.
  • Used patches contain enough medicine to be dangerous to children and pets, so store and dispose of the patches in a safe place out of their reach.
  • Might not be the best choice if you've had allergic reactions to numbing medications (local anesthetics) in the past.
  • Even though only small amounts of Lidoderm (Lidocaine) are absorbed into the body through the skin, if you're taking medications that treat arrhythmias, Lidoderm (Lidocaine) can affect how they work.
  • Patches shouldn't be left on for more than 12 hours, used on very large areas of skin, or covered with a heating pad.
Used for
Dosage forms
  • Pill
  • Liquid
  • Cream, gel, or ointment
  • Jelly
  • Spray
  • Topical solution
  • Patch
Price
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Reviews
66 reviews so far
47%
saidit'sworth it
42%
saiditworked well
32%
saidit'sa big hassle

Have you used Lyrica (pregabalin)?

Leave a review
18 reviews so far
67%
saidit'sworth it
72%
saiditworked well
22%
saidit'sa big hassle

Have you used Lidoderm (Lidocaine)?

Leave a review
Side effects
28possible side effects
  • Dizziness
    23%
  • Drowsiness
    13%
  • Headache
    11%
  • Blurry vision
    8%
  • Weight gain
    8%
  • Dry mouth
    7%
  • Fatigue
    5%
  • Swelling of the hands and feet
    5%
  • Constipation
    4%
  • Sinus infection
    4%
  • Increased appetite
    4%
  • Joint pain
    4%
  • Loss of focus
    4%
  • Feeling off balance
    2%
  • Vomiting
    2%
  • Abdominal distension
    2%
  • Chest pain
    2%
  • Fluid retention
    2%
  • Muscle spasms
    2%
  • Back pain
    2%
  • Balance disorder
    2%
  • Abnormal coordination
    2%
  • Partial loss of sensitivity to touch
    2%
  • Lethargy
    2%
  • Intense feeling of happiness
    2%
  • Anxiety
    2%
  • Depression
    2%
  • Sore throat
    2%
See more detailed side effects
The Lidoderm (Lidocaine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Suicidal thoughts or behavior
    • Starting Lyrica (pregabalin) or changing doses
  • Driving impairment
    • Taking Lyrica (pregabalin) with alcohol
    • Taking other medicines that make you drowsy
  • Giant hives (angioedema)
    • History of unusual swelling (angioedema)
    • Taking other medications (ie. lisinopril) that can cause angioedema
  • Heart problems
    • History of cardiovascular disease
  • Swelling of the hands and feet
    • Taking with certain diabetes medications
  • Withdrawal symptoms
    • Stopping Lyrica (pregabalin) suddenly
See more detailed risks and warnings
  • Overdose
    • Use of heating pad on skin
    • Applying patch to red, irritated or broken skin
    • Leaving patch on for more than 12 hours
    • Using patch on a very large area
    • Older age and lower body weight
    • Liver disease
  • Serious allergic reaction
    • Allergy to numbing medications (local anesthetics)
  • Accidental poisoning
    • Not disposing of Lidoderm (Lidocaine) correctly
    • Children and pets can reach medication
  • Eye irritation
    • Not washing hands after touching or applying Lidoderm (Lidocaine)
  • Skin reactions
    • Applying Lidoderm (Lidocaine) to warm skin
    • Covering patch with wrap or heating pad
  • Heart problems
    • History of heart problems
    • Using Lidoderm (Lidocaine) with drugs to treat irregular heartbeat
See more detailed risks and warnings