Compare Lyrica vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lyrica (pregabalin)

Prescription only

Norpramin (desipramine)

Prescription only
Treats pain caused by nerve damage and prevents seizures.

Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.

4.4/ 7 average rating with 66 reviewsforLyrica
Stabilizes your mood.

Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • It is less habit forming than narcotics.
  • It can also be used in combination with other anti-seizure medicines to treat epilepsy.
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
  • Likely expensive since it is not available in generic versions.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Requires adjustment in dose if you have lower kidney function.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
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Side effects
10possible side effects
  • Dizziness
  • Drowsiness
  • Headache
  • Blurry vision
  • Weight gain
  • Dry mouth
  • Fatigue
  • Swelling of the hands and feet
  • Constipation
  • Sinus infection
See more detailed side effects
The Norpramin (desipramine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Suicidal thoughts or behavior

    Starting Lyrica (pregabalin) or changing doses

  • Driving impairment

    Taking Lyrica (pregabalin) with alcohol

    ...and 1 more risk factors

  • Giant hives (angioedema)

    History of unusual swelling (angioedema)

    ...and 1 more risk factors

  • Heart problems

    History of cardiovascular disease

  • Swelling of the hands and feet

    Taking with certain diabetes medications

  • Withdrawal symptoms

    Stopping Lyrica (pregabalin) suddenly

See more detailed risks and warnings
  • Higher risk of suicide

    People under age 24

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 5 more risk factors

  • Changes to the heartbeat

    History of heart disease

  • Higher risk for seizures

    History of seizures

    ...and 1 more risk factors

See more detailed risks and warnings