Compare Lyrica vs. Norpramin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lyrica
(Pregabalin)

Norpramin
(Desipramine)

Treats nerve pain and prevents seizures. Lyrica (Pregabalin) works well as an add-on medicine for seizures and fibromyalgia, but it's especially effective for nerve-related pain after shingles. Not available as a generic, so it might be expensive.Coming soon.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.380952380952381Lyrica
Reviews for Lyrica (Pregabalin)
46%
of people say Lyrica (Pregabalin) is worth it
41%
say it works well
32%
say it's a big hassle

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Side effects
LyricaNorpramin
  • Dizziness 36%
  • Nerve damage 34%
  • Drowsiness 24%
  • Lack of muscle coordination 24%
  • Weight gain 15%
  • Constipation 13%
  • Weight increased 12%
  • Dry mouth 12%
  • Leg or ankle swelling 12%
  • Vision blurred 11%
More Lyrica side effects »

We haven’t found good data for Norpramin side effects.

FDA side effect reports for Norpramin »
How it works
LyricaNorpramin
Lyrica (Pregabalin) is a nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Coming soon.
Type of medication
LyricaNorpramin
Anticonvulsant
GABA analog
Prescription only
Coming soon.
Available as
LyricaNorpramin
  • Pill
  • Liquid
  • Pill
Used for (click to learn more)
LyricaNorpramin
  • Depression
Risk factors for serious side effects
LyricaNorpramin
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • History of unusual swelling (angioedema)
    • Taking other medications that can angioedema
    • History of cardiovascular disease
    • Taking with certain diabetes medications
    • Stopping Lyrica (Pregabalin) suddenly
      • Both male and females taking Lyrica (Pregabalin)
      Detailed Lyrica (Pregabalin) risks & warnings »
      Coming soon.
      Pregnancy category
      LyricaNorpramin
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      Alcohol
      • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
      No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Some people taking Lyrica (Pregabalin) develop muscle damage leading to kidney failure (rhabdomyolysis), however, this is very rare. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no other related cause.
      No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
      • Can make you drowsy or dizzy.
      • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
      No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      LyricaNorpramin
      • Relieves nerve-related (neuropathic) pain caused by different conditions including diabetes, shingles (herpes zoster), fibromyalgia, and spinal cord damage.
      • Studies show that lower doses of Lyrica (Pregabalin) cause fewer side effects and still relieve pain just as well as higher doses.
      • Also used in combination with other medications to treat epilepsy (partial seizures).
      Coming soon.
      Downsides and risks
      LyricaNorpramin
      • Not available as a generic, so it can be pricey.
      • You can't skip or miss doses since suddenly stopping Lyrica (Pregabalin) can cause seizures.
      • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
      • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
      Coming soon.
      Tips from our pharmacists for people taking the medication
      LyricaNorpramin
      • Some people feel relief from pain in a week.
      • Can make you drowsy or dizzy.
      • Don't stop taking it suddenly without talking to your doctor. You'll need to slowly lower your dose over at least a week to avoid withdrawal symptoms.
      • Tell your doctor if you have unexplained confusion or changes in your thoughts or behavior.
      • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
      Coming soon.
      Learn more
      More about LyricaSide effectsReviews & ratingsAlternativesFDA package insert
      More about NorpraminSide effectsReviews & ratingsFDA package insert