Compare Lyrica vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lyrica (pregabalin)

Prescription only

Pamelor (Nortriptyline)

Prescription only
Treats pain caused by nerve damage and prevents seizures.

Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.

4.4/ 7 average rating with 66 reviewsforLyrica
Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

5.5/ 7 average rating with 19 reviewsforPamelor
Upsides
  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • It is less habit forming than narcotics.
  • It can also be used in combination with other anti-seizure medicines to treat epilepsy.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Downsides
  • Likely expensive since it is not available in generic versions.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Requires adjustment in dose if you have lower kidney function.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
Lowest price near you
$431.1
Find instant savings
Lowest price near you
$4
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
66 
47%
think this treatment is worth it
42%
think this treatment works well
32%
think this treatment is a hassle

Have you used Lyrica (pregabalin)?

Leave a review
19 
79%
think this treatment is worth it
79%
think this treatment works well
21%
think this treatment is a hassle

Have you used Pamelor (Nortriptyline)?

Leave a review
Side effects
10possible side effects
  • Dizziness
    23%
  • Drowsiness
    13%
  • Headache
    11%
  • Blurry vision
    8%
  • Weight gain
    8%
  • Dry mouth
    7%
  • Fatigue
    5%
  • Swelling of the hands and feet
    5%
  • Constipation
    4%
  • Sinus infection
    4%
See more detailed side effects
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Suicidal thoughts or behavior

    Starting Lyrica (pregabalin) or changing doses

  • Driving impairment

    Taking Lyrica (pregabalin) with alcohol

    ...and 1 more risk factors

  • Giant hives (angioedema)

    History of unusual swelling (angioedema)

    ...and 1 more risk factors

  • Heart problems

    History of cardiovascular disease

  • Swelling of the hands and feet

    Taking with certain diabetes medications

  • Withdrawal symptoms

    Stopping Lyrica (pregabalin) suddenly

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Low blood pressure

    Age 65 years or older

  • Withdrawal

    Stopping Pamelor (Nortriptyline) suddenly

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Heart problems

    History of heart disease

    ...and 2 more risk factors

See more detailed risks and warnings