Compare Maalox vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Maalox
(Aluminum / Magnesium / Simethicone)

Pepcid
(Famotidine)

Relieves heartburn and acid tummy. Maalox (Aluminum / Magnesium / Simethicone) gives quick relief for heartburn, gas, and bloating. It may not be as effective or last as long as alternative antacids though.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.617924528301887Maalox
Reviews for Maalox (Aluminum / Magnesium / Simethicone)
68%
of people say Maalox (Aluminum / Magnesium / Simethicone) is worth it
30%
say it works well
9%
say it's a big hassle
Reviews for Pepcid (Famotidine)
75%
+7% vs. Maalox (Aluminum / Magnesium / Simethicone)
41%
+11% vs. Maalox (Aluminum / Magnesium / Simethicone)
8%
+1% vs. Maalox (Aluminum / Magnesium / Simethicone)
Side effects
MaaloxPepcid

We haven’t found good data for Maalox side effects.

FDA side effect reports for Maalox »

The Pepcid FDA package insert doesn’t have numbers about how common side effects are.

More about Pepcid side effects »
How it works
MaaloxPepcid
Maalox (Aluminum / Magnesium / Simethicone) is a combination medicine for stomach trouble. Aluminum and magnesium are antacids that relieve heartburn and acid tummy (indigestion). Simethicone relieves gas and bloating.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
MaaloxPepcid
AntacidOver-the-counter
Acid reducer
Histamine blocker
Prescription or OTC
Available as
MaaloxPepcid
  • Chewable tablet
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
MaaloxPepcid
Risk factors for serious side effects
MaaloxPepcid
  • Age 65 or older
    • Current kidney disease
      Detailed Maalox (Aluminum / Magnesium / Simethicone) risks & warnings »
        • Current kidney disease
          Detailed Pepcid (Famotidine) risks & warnings »
          Pregnancy category
          MaaloxPepcid
          NFDA pregnancy category (Unknown)

          The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Take 1-3 hours after a meal.
          No specific food-related info.
          Kidneys and liver
          • People with kidney disease may need to avoid Maalox. Ask your doctor.
          • If you have kidney disease Maalox (Aluminum / Magnesium / Simethicone) can build up in your blood. This may can cause toxic levels of aluminum or magnesium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Maalox (Aluminum / Magnesium / Simethicone); a different antacid would be better for you.
          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
          • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          MaaloxPepcid
          • Works really fast.
          • Available over the counter without a prescription.
          • Cheap.
          • Most people can take Famotidine without any noticeable day-to-day side effects.
          • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Few drug interactions.
          Downsides and risks
          MaaloxPepcid
          • Doesn't last very long.
          • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
          • Some people don't care for the taste.
          • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
          • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
          Tips from our pharmacists for people taking the medication
          MaaloxPepcid
          • Take 1-3 hours after a meal.
          • Take 1-2 hours apart from other medication that you take by mouth.
          • Tell your doctor if you have severe diarrhea or constipation.
          • People with kidney disease may need to avoid Maalox. Ask your doctor.
          • Short-term treatment of ulcers and acid reflux.
          Learn more
          More about MaaloxSide effectsReviews & ratingsAlternativesFDA package insert
          More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert