Compare Maalox vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Maalox
(aluminum / magnesium / simethicone)

Pepcid
(famotidine)

Relieves heartburn and indigestion. Maalox (aluminum / magnesium / simethicone) gives quick relief for heartburn, gas, and bloating, but it may not be as effective or last as long as other antacids.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.63Maalox
Reviews for Maalox
69%
of people (All ages) say Maalox is worth it
30%
say it works well
9%
say it's a big hassle
213 reviews
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it
Reviews for Pepcid
75%
-6% worse vs. Maalox
41%
-11% worse vs. Maalox
8%
-1% worse vs. Maalox
853 reviews
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it
Side effects
MaaloxPepcid

The Maalox FDA package insert doesn’t have numbers about how common side effects are.

More about Maalox side effects »
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »
How it works
MaaloxPepcid
Maalox (aluminum / magnesium / simethicone) is a combination medicine for heartburn and indigestion. Aluminum and magnesium are antacids that treat heartburn and indigestion. Simethicone relieves gas and bloating.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
MaaloxPepcid
Over-the-counterPrescription or OTC
Available as
MaaloxPepcid
  • Chewable tablet
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
Used for
MaaloxPepcid
Risk factors for serious side effects
MaaloxPepcid
  • Kidney problems
  • Taking more than the recommended daily maximum
Detailed Maalox (aluminum / magnesium / simethicone) risks & warnings »
  • Current kidney disease
Detailed Pepcid (famotidine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
MaaloxPepcid
No interactions related info.
  • Few drug interactions.
Food
MaaloxPepcid
  • Talk to your doctor or pharmacist about foods to avoid that can help prevent heartburn.
No food related info.
Kidneys and liver
MaaloxPepcid
  • Maalox (aluminum / magnesium / simethicone) contains aluminum and magnesium that can build up in your kidneys if you have kidney problems which can be dangerous. Talk to your doctor or pharmacist before taking Maalox (aluminum / magnesium / simethicone) to see if it is right for you. Don't take more than the maximum amount per day as shown on the label.
  • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Upsides and benefits
MaaloxPepcid
  • Works quickly.
  • Inexpensive and available over-the-counter.
  • Is one of the first choice medications for heartburn relief if you are pregnant.
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
Downsides and risks
MaaloxPepcid
  • Doesn't last very long. Talk to your doctor or pharmacist if you need longer lasting relief.
  • Is not a good option if you have frequent symptoms (more than 2 times a week). Talk to your doctor or pharmacist about stronger medications.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Tips from our pharmacists for people taking the medication
MaaloxPepcid
  • Starts working within minutes, and lasts for 1-2 hours.
  • If you are using the liquid product, shake well before using.
  • Don't take more than the recommended amount per day on the package. If you need to take this for more than 2 weeks, talk to your doctor.
  • People on a magnesium-restricted diet may need to avoid Maalox. Ask your doctor.
  • Talk to your doctor or pharmacist about foods to avoid that can help prevent heartburn.
  • Eating smaller portion sizes and not eating 3 hours before bedtime can help prevent heartburn.
  • Short-term treatment of ulcers and acid reflux.
Learn more
More about MaaloxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it
More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it