Compare Maalox vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Maalox (aluminum / magnesium / simethicone)

Over-the-counter

Pepcid (Famotidine)

Prescription or OTC
Relieves heartburn and indigestion.

Maalox (aluminum / magnesium / simethicone) gives quick relief for heartburn, gas, and bloating, but it may not be as effective or last as long as other antacids.

4.6/ 7 average rating with 213 reviewsforMaalox
Relieves heartburn.

Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.

5.1/ 7 average rating with 853 reviewsforPepcid
Upsides
  • Works quickly.
  • Inexpensive and available over-the-counter.
  • Is one of the first choice medications for heartburn relief if you are pregnant.
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
Downsides
  • Doesn't last very long. Talk to your doctor or pharmacist if you need longer lasting relief.
  • Is not a good option if you have frequent symptoms (more than 2 times a week). Talk to your doctor or pharmacist about stronger medications.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Used for
Dosage forms
  • Chewable tablet
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
Price
No pricing information available
Lowest price near you
$4
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Reviews
213 
69%
think this treatment is worth it
30%
think this treatment works well
9%
think this treatment is a hassle

Have you used Maalox (aluminum / magnesium / simethicone)?

Leave a review
853 
75%
think this treatment is worth it
41%
think this treatment works well
8%
think this treatment is a hassle

Have you used Pepcid (Famotidine)?

Leave a review
Side effects
The Maalox (aluminum / magnesium / simethicone) FDA package insert doesn’t have numbers about how common side effects are.
2possible side effects
  • Headache
    5%
  • Diarrhea
    2%
See more detailed side effects
Risks and warnings
  • Aluminum and magnesium overdose

    Kidney problems

    ...and 1 more risk factors

See more detailed risks and warnings
  • Increased side effects

    Current kidney disease

See more detailed risks and warnings