Compare Maalox vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Maalox
(aluminum / magnesium / simethicone)

Zantac 75
(ranitidine)

Relieves heartburn and acid tummy. Maalox (Aluminum / Magnesium / Simethicone) gives quick relief for heartburn, gas, and bloating. It may not be as effective or last as long as alternative antacids though.Relieves heartburn. Zantac 75 (Ranitidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
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4.63Maalox
Reviews for Maalox (aluminum / magnesium / simethicone)
69%
of people (All ages) say Maalox (aluminum / magnesium / simethicone) is worth it
30%
say it works well
9%
say it's a big hassle
213 reviews
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it
Reviews for Zantac 75 (ranitidine)
72%
+3% better vs. Maalox (aluminum / magnesium / simethicone)
44%
+14% better vs. Maalox (aluminum / magnesium / simethicone)
7%
+2% better vs. Maalox (aluminum / magnesium / simethicone)
1062 reviews
Have you used Zantac 75 (ranitidine)?
Worth itNot sureNot worth it
Side effects
MaaloxZantac

We haven’t found good data for Maalox side effects.

FDA side effect reports for Maalox »

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »
How it works
MaaloxZantac
Maalox (Aluminum / Magnesium / Simethicone) is a combination medicine for stomach trouble. Aluminum and magnesium are antacids that relieve heartburn and acid tummy (indigestion). Simethicone relieves gas and bloating.Zantac 75 (Ranitidine) is an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
MaaloxZantac
Over-the-counter
Prescription or OTC
Available as
MaaloxZantac
  • Chewable tablet
  • Liquid
  • Pill
  • Oral solution
  • Injection
Used for
MaaloxZantac
Risk factors for serious side effects
MaaloxZantac
  • Age 65 or older
  • Current kidney disease
Detailed Maalox (aluminum / magnesium / simethicone) risks & warnings »
  • Current kidney problems
  • Current liver problems
  • Acute Porphyria
  • History of Phenylketonuria (PKU)
Detailed Zantac 75 (ranitidine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
MaaloxZantac
No interactions related info.
  • Few drug interactions.
Food
MaaloxZantac
  • Take 1-3 hours after a meal.
No food related info.
Kidneys and liver
MaaloxZantac
  • People with kidney disease may need to avoid Maalox. Ask your doctor.
  • If you have kidney disease Maalox (Aluminum / Magnesium / Simethicone) can build up in your blood. This may can cause toxic levels of aluminum or magnesium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Maalox (Aluminum / Magnesium / Simethicone); a different antacid would be better for you.
  • People with kidney disease may need to take a lower dose.
  • Zantac 75 (Ranitidine) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent this increased risk for side effects.
Upsides and benefits
MaaloxZantac
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
  • Most people can take Ranitidine without any noticeable day-to-day side effects.
  • Ranitidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
Downsides and risks
MaaloxZantac
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Some people don't care for the taste.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Ranitidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Ranitidine (H2 blockers).
Tips from our pharmacists for people taking the medication
MaaloxZantac
  • Take 1-3 hours after a meal.
  • Take 1-2 hours apart from other medication that you take by mouth.
  • Tell your doctor if you have severe diarrhea or constipation.
  • People with kidney disease may need to avoid Maalox. Ask your doctor.
  • Works best if you take it with a full glass of water.
  • Starts working in one hour.
  • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
  • People with kidney disease may need to take a lower dose.
Learn more
More about MaaloxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it
More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zantac 75 (ranitidine)?
Worth itNot sureNot worth it