Compare maprotiline vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ludiomil (maprotiline)

Prescription only

Norpramin (desipramine)

Prescription only
Stabilizes your mood.

While Ludiomil (maprotiline) is part of the first choice of medicines to treat depression, it can cause drowsiness and dehydration.

Stabilizes your mood.

Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

Upsides
  • Ludiomil (maprotiline) is available in generic.
  • Ludiomil (maprotiline) doesn't cause sleep problems, unlike other medicines used to treat depression.
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
Downsides
  • Ludiomil (maprotiline) can make you very drowsy compared to other similar medicines.
  • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
  • Stopping Ludiomil (maprotiline) suddenly without telling your doctor can be dangerous.
  • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for several weeks.
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
Used for
Dosage forms
  • Pill
  • Pill
Price
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$25.39
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$15.87
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Reviews
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Side effects
10possible side effects
  • Dry mouth
    22%
  • Drowsiness
    16%
  • Dizziness
    8%
  • Constipation
    6%
  • Nervousness
    6%
  • Weakness & fatigue
    4%
  • Headache
    4%
  • Vision changes
    4%
  • Anxiety
    3%
  • Difficulty controlling movements
    3%
See more detailed side effects
The Norpramin (desipramine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Higher risk of suicide

    People under age 24

  • Heart problems

    History of heart attack or heart disease

See more detailed risks and warnings
  • Higher risk of suicide

    People under age 24

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 5 more risk factors

  • Changes to the heartbeat

    History of heart disease

  • Higher risk for seizures

    History of seizures

    ...and 1 more risk factors

See more detailed risks and warnings