Compare maprotiline vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ludiomil
(maprotiline)

Norpramin
(desipramine)

Stabilizes your mood. While Ludiomil (maprotiline) is part of the first choice of medicines to treat depression, it can cause drowsiness and dehydration.Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.
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Coupons for maprotiline
Best available price for 30 (50mg) tablets of maprotiline
Coupons for desipramine
Best available price for 30 (25mg) tablets of desipramine
Reviews & ratings
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Have you used Ludiomil (maprotiline)?
Worth itNot sureNot worth it

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Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
Side effects
maprotilinedesipramine
  • Dry mouth 22%
  • Drowsiness 16%
  • Dizziness 8%
  • Constipation 6%
  • Nervousness 6%
  • Weakness & fatigue 4%
  • Headache 4%
  • Vision changes 4%
  • Anxiety 3%
  • Difficulty controlling movements 3%
More maprotiline side effects »

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
How it works
maprotilinedesipramine
Ludiomil (maprotiline) is a tricyclic antidepressant. It raises the amount of norepinephrine in the brain, which is believed to be one of the chemicals that regulates mood.Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.
Type of medication
maprotilinedesipramine
Prescription onlyPrescription only
Available as
maprotilinedesipramine
  • Pill
  • Pill
Used for
maprotilinedesipramine
Risk factors for serious side effects
maprotilinedesipramine
  • People under age 24
  • History of heart attack or heart disease
Detailed Ludiomil (maprotiline) risks & warnings »
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Norpramin (desipramine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Weight
maprotilinedesipramine
  • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
No weight related info.
Upsides and benefits
maprotilinedesipramine
  • Ludiomil (maprotiline) is available in generic.
  • Ludiomil (maprotiline) doesn't cause sleep problems, unlike other medicines used to treat depression.
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
Downsides and risks
maprotilinedesipramine
  • Ludiomil (maprotiline) can make you very drowsy compared to other similar medicines.
  • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
  • Stopping Ludiomil (maprotiline) suddenly without telling your doctor can be dangerous.
  • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for several weeks.
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
Tips from our pharmacists for people taking the medication
maprotilinedesipramine
  • If you've taken Ludiomil (maprotiline) for a long time, don't stop taking it suddenly without talking to your doctor first. It can be very dangerous.
  • Don't drive or do anything requiring concentration while taking Ludiomil (maprotiline) until you know how it affects you since it can make you sleepy. This can be worse if you drink alcohol or take narcotics.
  • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for at least a few weeks.
  • If you forget your regular dose of Ludiomil (maprotiline), take it as soon as you remember. However, don't take 2 doses at the same time if it's already time for your next dose.
  • You might feel dizzy the first few days you take Ludiomil (maprotiline), which can make you fall. Be very careful getting up if you've been sitting or lying down for a while. Brace yourself and sit back down if you're feeling dizzy.
  • Ludiomil (maprotiline) can also cause constipation. Eat plenty of fruits and vegetables, or use stool softeners or laxatives.
  • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
  • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
  • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
  • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
Learn more
More about maprotilineSide effectsAlternativesFDA package insert
Have you used Ludiomil (maprotiline)?
Worth itNot sureNot worth it
More about desipramineSide effectsAlternativesFDA package insert
Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it