Compare maprotiline vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ludiomil (maprotiline)

Prescription only

Zonalon (Doxepin)

Prescription only
Stabilizes your mood.

While Ludiomil (maprotiline) is part of the first choice of medicines to treat depression, it can cause drowsiness and dehydration.

Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Upsides
  • Ludiomil (maprotiline) is available in generic.
  • Ludiomil (maprotiline) doesn't cause sleep problems, unlike other medicines used to treat depression.
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
Downsides
  • Ludiomil (maprotiline) can make you very drowsy compared to other similar medicines.
  • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
  • Stopping Ludiomil (maprotiline) suddenly without telling your doctor can be dangerous.
  • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for several weeks.
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
Used for
  • Skin intching (moderate)
Dosage forms
  • Pill
  • Cream, gel, or ointment
Price
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$25.39
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Lowest price near you
$9.99
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Side effects
10possible side effects
  • Dry mouth
    22%
  • Drowsiness
    16%
  • Dizziness
    8%
  • Constipation
    6%
  • Nervousness
    6%
  • Weakness & fatigue
    4%
  • Headache
    4%
  • Vision changes
    4%
  • Anxiety
    3%
  • Difficulty controlling movements
    3%
See more detailed side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Higher risk of suicide

    People under age 24

  • Heart problems

    History of heart attack or heart disease

See more detailed risks and warnings