Compare maprotiline vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ludiomil
(maprotiline)

Zonalon
(doxepin)

Stabilizes your mood. While Ludiomil (maprotiline) is part of the first choice of medicines to treat depression, it can cause drowsiness and dehydration.Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.
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Coupons for maprotiline
Best available price for 30 (50mg) tablets of maprotiline
Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Reviews & ratings
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Ludiomil (maprotiline)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it
Side effects
maprotilineDoxepin
  • Dry mouth 22%
  • Drowsiness 16%
  • Dizziness 8%
  • Constipation 6%
  • Nervousness 6%
  • Weakness & fatigue 4%
  • Headache 4%
  • Vision changes 4%
  • Anxiety 3%
  • Difficulty controlling movements 3%
More maprotiline side effects »

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »
How it works
maprotilineDoxepin
Ludiomil (maprotiline) is a tricyclic antidepressant. It raises the amount of norepinephrine in the brain, which is believed to be one of the chemicals that regulates mood.Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.
Type of medication
maprotilineDoxepin
Prescription onlyPrescription only
Available as
maprotilineDoxepin
  • Pill
  • Cream, gel, or ointment
Used for
maprotilineDoxepin
  • Skin Intching Moderate
Risk factors for serious side effects
maprotilineDoxepin
  • People under age 24
  • History of heart attack or heart disease
Detailed Ludiomil (maprotiline) risks & warnings »
    Detailed Zonalon (doxepin) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Price
    maprotilineDoxepin
    No price related info.
    • It isn't available as a generic, so it could be kind of pricey.
    Interactions
    maprotilineDoxepin
    No interactions related info.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Sleep
    maprotilineDoxepin
    No sleep related info.
    • Zonalon (Doxepin) can make you sleepy.
    Weight
    maprotilineDoxepin
    • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
    No weight related info.
    Upsides and benefits
    maprotilineDoxepin
    • Ludiomil (maprotiline) is available in generic.
    • Ludiomil (maprotiline) doesn't cause sleep problems, unlike other medicines used to treat depression.
    • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
    • You can use Zonalon (Doxepin) for up to 8 days at a time.
    Downsides and risks
    maprotilineDoxepin
    • Ludiomil (maprotiline) can make you very drowsy compared to other similar medicines.
    • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
    • Stopping Ludiomil (maprotiline) suddenly without telling your doctor can be dangerous.
    • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for several weeks.
    • You need a prescription for Zonalon (Doxepin).
    • It isn't available as a generic, so it could be kind of pricey.
    • Zonalon (Doxepin) can make you sleepy.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Tips from our pharmacists for people taking the medication
    maprotilineDoxepin
    • If you've taken Ludiomil (maprotiline) for a long time, don't stop taking it suddenly without talking to your doctor first. It can be very dangerous.
    • Don't drive or do anything requiring concentration while taking Ludiomil (maprotiline) until you know how it affects you since it can make you sleepy. This can be worse if you drink alcohol or take narcotics.
    • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for at least a few weeks.
    • If you forget your regular dose of Ludiomil (maprotiline), take it as soon as you remember. However, don't take 2 doses at the same time if it's already time for your next dose.
    • You might feel dizzy the first few days you take Ludiomil (maprotiline), which can make you fall. Be very careful getting up if you've been sitting or lying down for a while. Brace yourself and sit back down if you're feeling dizzy.
    • Ludiomil (maprotiline) can also cause constipation. Eat plenty of fruits and vegetables, or use stool softeners or laxatives.
    • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
    • Wash your hands before and after using it.
    • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
    • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
    • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
    Learn more
    More about maprotilineSide effectsAlternativesFDA package insert
    Have you used Ludiomil (maprotiline)?
    Worth itNot sureNot worth it
    More about DoxepinSide effectsFDA package insert
    Have you used Zonalon (doxepin)?
    Worth itNot sureNot worth it