Compare maprotiline vs. Silenor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ludiomil
(maprotiline)

Silenor
(doxepin)

Stabilizes your mood. While Ludiomil (maprotiline) is part of the first choice of medicines to treat depression, it can cause drowsiness and dehydration.Helps you relax, and sleep. Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.
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Coupons for maprotiline
Best available price for 30 (50mg) tablets of maprotiline
Coupons for Silenor
Best available price for 30 (10mg) capsules of doxepin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Ludiomil (maprotiline)
Not enough review data. Review it!
of people (All ages) say Ludiomil (maprotiline) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Ludiomil (maprotiline)?
Worth itNot sureNot worth it
Reviews for Silenor (doxepin)
Not enough review data. Review it!
+100% better vs. Ludiomil (maprotiline)
Not enough review data. Review it!
+50% better vs. Ludiomil (maprotiline)
Not enough review data. Review it!
Same vs. Ludiomil (maprotiline)
Have you used Silenor (doxepin)?
Worth itNot sureNot worth it
Side effects
maprotilineSilenor
  • Dry mouth 22%
  • Drowsiness 16%
  • Dizziness 8%
  • Constipation 6%
  • Nervousness 6%
  • Weakness & fatigue 4%
  • Headache 4%
  • Vision changes 4%
  • Anxiety 3%
  • Difficulty controlling movements 3%
More maprotiline side effects »

We haven’t found good data for Silenor side effects.

FDA side effect reports for Silenor »
How it works
maprotilineSilenor
Ludiomil (maprotiline) is a tricyclic antidepressant. It raises the amount of norepinephrine in the brain, which is believed to be one of the chemicals that regulates mood.Doxepin is a tricyclic antidepressant. It keeps norepinephrine and serotonin in your brain longer, helping you relax, and sleep. It also blocks the chemical that causes itch, and wakefulness.
Type of medication
maprotilineSilenor
Prescription only
Available as
maprotilineSilenor
  • Pill
  • Pill
  • Liquid
Used for
maprotilineSilenor
  • Alcoholism Anxiety Depression Anxiety Depression Anxiety Depression Psychoneurotic Personality Disorder Insomnia Pruritus Moderate
Risk factors for serious side effects
maprotilineSilenor
  • People under age 24
  • History of heart attack or heart disease
Detailed Ludiomil (maprotiline) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    maprotilineSilenor
    No interactions related info.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    Alcohol
    maprotilineSilenor
    No alcohol related info.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    Weight
    maprotilineSilenor
    • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
    • Doxepin can increase your appetite, leading to weight gain.
    Upsides and benefits
    maprotilineSilenor
    • Ludiomil (maprotiline) is available in generic.
    • Ludiomil (maprotiline) doesn't cause sleep problems, unlike other medicines used to treat depression.
    • In a clinical trial Doxepin was able to significantly improve sleep quality.
    • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
    • Once your body gets used to Doxepin, most of the side effects go away.
    • Doxepin comes in a generic form, so it is pretty cheap.
    • Doxepin is not addictive.
    Downsides and risks
    maprotilineSilenor
    • Ludiomil (maprotiline) can make you very drowsy compared to other similar medicines.
    • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
    • Stopping Ludiomil (maprotiline) suddenly without telling your doctor can be dangerous.
    • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for several weeks.
    • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
    • Doxepin can increase your appetite, leading to weight gain.
    • Taking Doxepin can make emptying your bladder difficult.
    • Some people have suicidal thoughts when taking Doxepin.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    Tips from our pharmacists for people taking the medication
    maprotilineSilenor
    • If you've taken Ludiomil (maprotiline) for a long time, don't stop taking it suddenly without talking to your doctor first. It can be very dangerous.
    • Don't drive or do anything requiring concentration while taking Ludiomil (maprotiline) until you know how it affects you since it can make you sleepy. This can be worse if you drink alcohol or take narcotics.
    • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for at least a few weeks.
    • If you forget your regular dose of Ludiomil (maprotiline), take it as soon as you remember. However, don't take 2 doses at the same time if it's already time for your next dose.
    • You might feel dizzy the first few days you take Ludiomil (maprotiline), which can make you fall. Be very careful getting up if you've been sitting or lying down for a while. Brace yourself and sit back down if you're feeling dizzy.
    • Ludiomil (maprotiline) can also cause constipation. Eat plenty of fruits and vegetables, or use stool softeners or laxatives.
    • Take Doxepin 30 minutes before bedtime so it starts working when you get in bed.
    • Avoid activities that need you to be fully alert like driving, until you know how Doxepin affects you.
    • Follow up with your doctor so he or she can make sure Doxepin is the right medication for your depression.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    • Some people get dry mouth, or constipation when taking Doxepin. Sugar free gum or candy can help the dry mouth, and drinking more fluid can help with constipation.
    • Avoid direct sunlight while taking this medication. When you can’t avoid it, be sure to use sunscreen. It’s also important to put on a long-sleeved shirt, pants, hat, and sunglasses.
    Learn more
    More about maprotilineSide effectsAlternativesFDA package insert
    Have you used Ludiomil (maprotiline)?
    Worth itNot sureNot worth it
    More about SilenorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Silenor (doxepin)?
    Worth itNot sureNot worth it