Compare maprotiline vs. Vivactil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ludiomil
(maprotiline)

Vivactil
(protriptyline)

Stabilizes your mood. While Ludiomil (maprotiline) is part of the first choice of medicines to treat depression, it can cause drowsiness and dehydration.Improves your mood. Vivactil (protriptyline) is part of the first choice of medicines for depression, but it can cause problems with your heartbeat and change your sex drive.
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Coupons for maprotiline
Best available price for 30 (50mg) tablets of maprotiline
Coupons for Vivactil
Best available price for 60 (5mg) tablets of vivactil
Reviews & ratings
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Have you used Ludiomil (maprotiline)?
Worth itNot sureNot worth it

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Have you used Vivactil (protriptyline)?
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Side effects
maprotilineVivactil
  • Dry mouth 22%
  • Drowsiness 16%
  • Dizziness 8%
  • Constipation 6%
  • Nervousness 6%
  • Weakness & fatigue 4%
  • Headache 4%
  • Vision changes 4%
  • Anxiety 3%
  • Difficulty controlling movements 3%
More maprotiline side effects »

The Vivactil FDA package insert doesn’t have numbers about how common side effects are.

More about Vivactil side effects »
How it works
maprotilineVivactil
Ludiomil (maprotiline) is a tricyclic antidepressant. It raises the amount of norepinephrine in the brain, which is believed to be one of the chemicals that regulates mood.Vivactil (protriptyline) is a tricyclic antidepressant. It regulates mood by raising the amount of serotonin and norepinephrine in the brain.
Type of medication
maprotilineVivactil
Prescription onlyPrescription only
Available as
maprotilineVivactil
  • Pill
  • Pill
Used for
maprotilineVivactil
Risk factors for serious side effects
maprotilineVivactil
  • People under age 24
  • History of heart attack or heart disease
Detailed Ludiomil (maprotiline) risks & warnings »
  • Under age 24
  • History of heart disease
  • Overactive thyroid
  • History of seizures
  • High blood pressure
Detailed Vivactil (protriptyline) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Weight
maprotilineVivactil
  • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
No weight related info.
Upsides and benefits
maprotilineVivactil
  • Ludiomil (maprotiline) is available in generic.
  • Ludiomil (maprotiline) doesn't cause sleep problems, unlike other medicines used to treat depression.
  • Vivactil (protriptyline) is part of the first choice medicines for treating depression.
  • Compared to similar medicines, Vivactil (protriptyline) is less likely to make you feel sleepy.
  • Available in generic.
Downsides and risks
maprotilineVivactil
  • Ludiomil (maprotiline) can make you very drowsy compared to other similar medicines.
  • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
  • Stopping Ludiomil (maprotiline) suddenly without telling your doctor can be dangerous.
  • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for several weeks.
  • Vivactil (protriptyline) can lower your sex drive more than some other similar medicines.
  • Because Vivactil (protriptyline) can cause dizziness, people age 65 and older need to take precautions when taking Vivactil (protriptyline).
  • Vivactil (protriptyline) can worsen heart conditions. If you have a history of heart problems, you may need to have regular testing for your heart.
Tips from our pharmacists for people taking the medication
maprotilineVivactil
  • If you've taken Ludiomil (maprotiline) for a long time, don't stop taking it suddenly without talking to your doctor first. It can be very dangerous.
  • Don't drive or do anything requiring concentration while taking Ludiomil (maprotiline) until you know how it affects you since it can make you sleepy. This can be worse if you drink alcohol or take narcotics.
  • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for at least a few weeks.
  • If you forget your regular dose of Ludiomil (maprotiline), take it as soon as you remember. However, don't take 2 doses at the same time if it's already time for your next dose.
  • You might feel dizzy the first few days you take Ludiomil (maprotiline), which can make you fall. Be very careful getting up if you've been sitting or lying down for a while. Brace yourself and sit back down if you're feeling dizzy.
  • Ludiomil (maprotiline) can also cause constipation. Eat plenty of fruits and vegetables, or use stool softeners or laxatives.
  • Take Vivactil (protriptyline) at night since it can make you sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • You might have to take Vivactil (protriptyline) for a few weeks before you notice any changes in your mood.
  • Vivactil (protriptyline) can make you more sensitive to the sun. Wear sunscreen or cover your skin if you're going to be out in the sun for a while.
  • Don't stop taking Vivactil (protriptyline) without talking to your doctor first.
  • Be very careful getting up if you've been sitting or lying down for a while since Vivactil (protriptyline) can make you feel dizzy.
Learn more
More about maprotilineSide effectsAlternativesFDA package insert
Have you used Ludiomil (maprotiline)?
Worth itNot sureNot worth it
More about VivactilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vivactil (protriptyline)?
Worth itNot sureNot worth it