Compare maprotiline vs. Vivactil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ludiomil (maprotiline)

Prescription only

Vivactil (protriptyline)

Prescription only
Stabilizes your mood.

While Ludiomil (maprotiline) is part of the first choice of medicines to treat depression, it can cause drowsiness and dehydration.

Improves your mood.

Vivactil (protriptyline) is part of the first choice of medicines for depression, but it can cause problems with your heartbeat and change your sex drive.

Upsides
  • Ludiomil (maprotiline) is available in generic.
  • Ludiomil (maprotiline) doesn't cause sleep problems, unlike other medicines used to treat depression.
  • Vivactil (protriptyline) is part of the first choice medicines for treating depression.
  • Compared to similar medicines, Vivactil (protriptyline) is less likely to make you feel sleepy.
  • Available in generic.
Downsides
  • Ludiomil (maprotiline) can make you very drowsy compared to other similar medicines.
  • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
  • Stopping Ludiomil (maprotiline) suddenly without telling your doctor can be dangerous.
  • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for several weeks.
  • Vivactil (protriptyline) can lower your sex drive more than some other similar medicines.
  • Because Vivactil (protriptyline) can cause dizziness, people age 65 and older need to take precautions when taking Vivactil (protriptyline).
  • Vivactil (protriptyline) can worsen heart conditions. If you have a history of heart problems, you may need to have regular testing for your heart.
Used for
Dosage forms
  • Pill
  • Pill
Price
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$25.39
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$32.78
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Side effects
10possible side effects
  • Dry mouth
    22%
  • Drowsiness
    16%
  • Dizziness
    8%
  • Constipation
    6%
  • Nervousness
    6%
  • Weakness & fatigue
    4%
  • Headache
    4%
  • Vision changes
    4%
  • Anxiety
    3%
  • Difficulty controlling movements
    3%
See more detailed side effects
The Vivactil (protriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Higher risk of suicide

    People under age 24

  • Heart problems

    History of heart attack or heart disease

See more detailed risks and warnings
  • Higher risk of suicide

    Under age 24

  • Heart problems

    History of heart disease

    ...and 1 more risk factors

  • Higher risk of seizures

    History of seizures

  • Changes in blood pressure

    High blood pressure

See more detailed risks and warnings