Compare Medrol vs. fludrocortisone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Fludrocortisone

Prescription only
Calms down your immune system.

Medrol (methylprednisolone) is very effective for controlling allergic reactions and many types of inflammatory conditions, but it is associated with serious and potentially life-threatening side effects if you have to take it for a long time.

3.7/ 5 average rating with 66 reviewsforMedrol
Treats electrolyte imbalance.

Fludrocortisone is one of the first choices used in Addison's disease to help maintain your electrolytes, but there are side effects.

Upsides
  • Medrol (methylprednisolone) is effective for treating a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Medrol (methylprednisolone) is available in a generic form.
  • Available as blister packs that organize tablets into specific days and times for easier administration.
  • Fludrocortisone is effective in correcting electrolyte imbalances associated with Addison's disease.
  • Generic is available.
  • Only need to take it once daily.
Downsides
  • Medrol (methylprednisolone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Medrol (methylprednisolone) is used for more than 2 weeks, you will need to work with a doctor to get off of the medicine by gradually decreasing the dose.
  • Medrol (methylprednisolone) can cause harm to an unborn baby, so it might not be a good option for pregnant women.
  • Might cause abnormal growth and development when used in children.
  • Fludrocortisone can cause reactivation of old infections such as Hepatits B, C, or tuberculosis.
  • Fludrocortisone can make it easier for you to get sick.
  • Fludrocortisone can interact with other drugs and vaccines.
  • While on Fludrocortisone, you may need to have blood tests done for monitoring.
Used for
  • Addison's disease
  • Congential adrenal hyperplasia
Dosage forms
  • Pill
  • Injection
  • Pill
Price
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Reviews
66 reviews so far
59%
saidit'sworth it
53%
saiditworked well
23%
saidit'sa big hassle

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Side effects
The Medrol (methylprednisolone) FDA package insert doesn’t have numbers about how common side effects are.
The Fludrocortisone FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Weakened immune system response to stress
    • Taking high doses of Medrol (methylprednisolone) for a long period of time
    • Young children
    • Stress such as trauma, injury, or infection
  • Increased risk for infections
    • Taking other medicines that weaken the immune system
    • Taking Medrol (methylprednisolone) for a long time
    • Those who are not vaccinated against viral illnesses
    • Coming into contact with people who have viral illness
    • History of bacterial or viral conditions
  • Changes in heart and kidney function
    • Those who had a recent heart attack
    • History of heart failure, high blood pressure, and kidney problems
  • Eye problems
    • Those with cataracts and/or glaucoma
    • History of herpes simplex in the eye
  • Harm to fetus (unborn baby)
    • Pregnant women
    • Women who can or plan to become pregnant
See more detailed risks and warnings
  • Lowered adrenal function
    • Lowering dose or stopping too quickly especially after long-term treatment
    • Stress such as trauma, surgery or infection
  • Increased risk for infections
    • Taking other immunosuppressants
    • Long-term treatment
    • Not vaccinated against viral diseases
    • Contact with people who have viral illness
    • History of bacterial or viral conditions
  • Changes in electrolyte balance
  • Eye problems
  • Bone effects
    • Dose of Fludrocortisone
    • Duration of treatment
  • Stomach and intestinal problems
    • History of stomach bleeding
    • Active or history of stomach ulcers
    • Ulcerative colitis
    • Taking Fludrocortisone with other medicine that can cause stomach problems
See more detailed risks and warnings