Compare meloxicam vs. Naproxen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mobic
(meloxicam)

Aleve
(naproxen)

Relieves pain and inflammation. Mobic (meloxicam) works well for pain and inflammation and you only take it once a day, but you need a prescription.Relieves pain, fever, and inflammation. Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.
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Prices and coupon for 30 (15mg) tablets of meloxicam
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Prices and coupon for 60 (500mg) tablets of naproxen
Reviews & ratings
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5.13meloxicam
Reviews for Mobic (meloxicam)
64%
of people (All ages) say Mobic (meloxicam) is worth it
54%
say it works well
13%
say it's a big hassle
141 reviews
Have you used Mobic (meloxicam)?
Worth itNot sureNot worth it
Reviews for Aleve (naproxen)
78%
+14% better vs. Mobic (meloxicam)
48%
-6% worse vs. Mobic (meloxicam)
5%
+8% better vs. Mobic (meloxicam)
978 reviews
Have you used Aleve (naproxen)?
Worth itNot sureNot worth it
Side effects
meloxicamNaproxen
  • Indigestion 10%
  • Ear, nose, or throat infection 8%
  • Nausea 7%
  • Urinary tract infection 7%
  • Pain 5%
  • Abdominal pain 3%
  • Constipation 3%
  • Diarrhea 3%
  • Gas 3%
  • Vomiting 3%
More meloxicam side effects »

The Naproxen FDA package insert doesn’t have numbers about how common side effects are.

More about Naproxen side effects »
How it works
meloxicamNaproxen
Mobic (meloxicam) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves pain and swelling.Aleve (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.
Type of medication
meloxicamNaproxen
Prescription only
Prescription or OTC
Available as
meloxicamNaproxen
  • Pill
  • Suspension
  • Pill
  • Delayed release tablet
  • Liquid
Used for
meloxicamNaproxen
Risk factors for serious side effects
meloxicamNaproxen
  • History of heart problems
  • Taking the medicine for a long period of time
  • History of stomach bleeding
  • Age 60 or older
  • Taking aspirin, other NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Smoking
  • Taking the medicine for a long time
  • Asthma
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking certain high blood pressure medications
  • Age 60 or older
  • Taking the medicine for a long period of time
  • Women who want to or can become pregnant
  • Pregnant women
Detailed Mobic (meloxicam) risks & warnings »
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Hemophilia
  • von Willebrand's disease
  • Low blood platelet count
  • Taking anticoagulant medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • Women of childbearing age
Detailed Aleve (naproxen) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
meloxicamNaproxen
  • It should be taken only once a day, with food or milk to prevent stomach upset.
  • It needs to be taken with food to avoid getting an upset stomach.
  • Take it with a meal or a snack to prevent an upset stomach.
Kidneys and liver
meloxicamNaproxen
  • Mobic (meloxicam) can damage your kidneys if you take it for a very long time. Taking the lowest dose for the shortest amount of time lowers your risk. Talk to your doctor if this worries you, or if you already have kidney damage before you start taking Mobic (meloxicam).
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Aleve (Naproxen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Aleve (Naproxen) for any amount of time.
Pain
meloxicamNaproxen
  • Works well to relieve pain and inflammation due to osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Mobic (meloxicam) can cause stomach bleeding which can be dangerous. If you notice blood in your vomit or your stool has bright red blood or looks like black coffee grounds, or if you have pain in your stomach that doesn't go away, talk to your doctor right away.
  • Works well to relieve pain, swelling, and fevers.
  • Starts relieving pain in 30 to 60 minutes.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
Upsides and benefits
meloxicamNaproxen
  • Taken only once a day, while other NSAIDS need to be taken a few times a day for the same effect.
  • Works well to relieve pain and inflammation due to osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Causes less stomach upset than other NSAIDs.
  • Relatively cheap compared to other prescription NSAIDS.
  • Works well to relieve pain, swelling, and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Lasts longer than Ibuprofen, so you can take it less often.
  • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
Downsides and risks
meloxicamNaproxen
  • Mobic (meloxicam) does not kick in as fast as other NSAIDS.
  • It's available by prescription only.
  • Mobic (meloxicam) is not as safe as other alternatives for pregnant women and people who are age 60 or older.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long time.
  • It needs to be taken with food to avoid getting an upset stomach.
  • Can't be taken by pregnant women.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
Tips from our pharmacists for people taking the medication
meloxicamNaproxen
  • It should be taken only once a day, with food or milk to prevent stomach upset.
  • Mobic (meloxicam) increases the risk of stomach bleeding so tell your doctor right away if you experience any bleeding.
  • Do not take Mobic (meloxicam) with any blood thinners unless your doctor says so.
  • If you are allergic to aspirin, you may be allergic to Mobic (meloxicam) as well.
  • The capsule, suspension, and tablet forms of the medicine come in different strengths, so be careful when switching from one form to another.
  • Starts relieving pain in 30 to 60 minutes.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
Learn more
More about meloxicamSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Mobic (meloxicam)?
Worth itNot sureNot worth it
More about NaproxenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aleve (naproxen)?
Worth itNot sureNot worth it