Compare Mercaptopurine vs. Sulfasalazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Purinethol
(Mercaptopurine)

Azulfidine
(Sulfasalazine)

Coming soon.Reduces inflammation. Azulfidine (Sulfasalazine) is used for moderate to severe inflammatory bowel conditions, and with other meds for treating rheumatoid arthritis.
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Reviews & ratings
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Have you used Purinethol (Mercaptopurine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Azulfidine (Sulfasalazine)?
Worth itNot sureNot worth it
Side effects
MercaptopurineSulfasalazine

We haven’t found good data for Mercaptopurine side effects.

FDA side effect reports for Mercaptopurine »

We haven’t found good data for Sulfasalazine side effects.

FDA side effect reports for Sulfasalazine »
How it works
MercaptopurineSulfasalazine
Coming soon.Azulfidine (Sulfasalazine) is an anti-inflammatory drug that reduces inflammation and pain. It treats inflammatory bowel diseases and rheumatoid arthritis.
Type of medication
MercaptopurineSulfasalazine
Coming soon.
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Available as
MercaptopurineSulfasalazine
  • Pill
  • Liquid
  • Pill
  • Extended release
Used for (click to learn more)
MercaptopurineSulfasalazine
  • Acute lymphoid leukemia
Risk factors for serious side effects
MercaptopurineSulfasalazine
Coming soon.
          Detailed Azulfidine (Sulfasalazine) risks & warnings »
          Pregnancy

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Food
          MercaptopurineSulfasalazine
          No food related info.
          • Swallow tablets whole, and take after a meal with a full glass of water.
          Kidneys and liver
          MercaptopurineSulfasalazine
          No kidneys and liver related info.
          • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
          • Severe hypersensitivity reactions can include internal organ involvement, such as hepatitis (liver), nephritis (kidney), myocarditis (heart), blood abnormalities, or pneumonitis (lungs).
          Upsides and benefits
          MercaptopurineSulfasalazine
          Coming soon
          • When taken consistently, Azulfidine (Sulfasalazine) can control your symptoms of ulcerative colitis and other bowel diseases.
          • Azulfidine (Sulfasalazine) is usually used in combination with other medications to control rheumatoid arthritis.
          Downsides and risks
          MercaptopurineSulfasalazine
          Coming soon
          • You need to have blood tests every 3 months when taking Azulfidine (Sulfasalazine).
          • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
          • Can't take Azulfidine (Sulfasalazine) if you are allergic to aspirin or sulfa medications.
          • Azulfidine (Sulfasalazine) shouldn't be used if you are breastfeeding.
          Tips from our pharmacists for people taking the medication
          MercaptopurineSulfasalazine
          Coming soon
          • Don't use if you are allergic to sulfa drugs or aspirin.
          • Swallow tablets whole, and take after a meal with a full glass of water.
          • Drink at least six glasses of water daily while on this.
          • Continue to take Azulfidine (Sulfasalazine) even once you feel better.
          • Read the information that come with your medication in the drugstore since there are many conditions you should be aware of before taking Azulfidine (Sulfasalazine).
          • Can cause an orange color in your urine or skin.
          Learn more
          More about MercaptopurineSide effectsFDA package insert
          Have you used Purinethol (Mercaptopurine)?
          Worth itNot sureNot worth it
          More about SulfasalazineSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Azulfidine (Sulfasalazine)?
          Worth itNot sureNot worth it