Compare Metaglip vs. Actos

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Metaglip
(metformin / glipizide)

Actos
(pioglitazone)

Coming soon.Lowers blood sugar. Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.
Reviews & ratings
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Have you used Metaglip (metformin / glipizide)?
Worth itNot sureNot worth it
Reviews for Actos
42%
-42% worse vs. Metaglip
30%
-30% worse vs. Metaglip
21%
+21% better vs. Metaglip
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Side effects
MetaglipActos

We haven’t found good data for Metaglip side effects.

FDA side effect reports for Metaglip »
  • Swelling 11%
  • Low blood sugar 8%
  • Colds and flu 4%
  • Headache 2%
  • Heart failure 2%
  • Sinus infection 1%
  • Back pain 1%
  • Muscle pain 2%
More Actos side effects »
How it works
MetaglipActos
Coming soon.Actos (pioglitazone) is a thiazolidinedione that improves your body's ability to use insulin to lower your blood sugar.
Type of medication
MetaglipActos
Prescription only
Available as
MetaglipActos
  • Pill
  • Pill
Used for
MetaglipActos
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
MetaglipActos
    Coming soon.
    • Heart failure
    • Current liver problems
    • History of bladder cancer
    • Women
    Detailed Actos (pioglitazone) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    MetaglipActos
    No food related info.
    • Take once a day with or without food.
    Kidneys and liver
    MetaglipActos
    No kidneys and liver related info.
    • If you've had liver problems or damage in the past, talk to your doctor before starting Actos (pioglitazone), since there's a small chance that it can hurt your liver. Tell your doctor about any stomach pain that don't go away, dark urine, or yellowing of eyes/skin. Your doctor will check your liver regularly.
    Weight
    MetaglipActos
    No weight related info.
    • Can cause weight gain, headache, and swelling from fluid build-up.
    • Can cause weight gain.
    Upsides and benefits
    MetaglipActos
    Coming soon
    • Improves sugar control and lowers A1c levels by around 1%.
    • Easily taken by mouth as a once a day pill.
    • Prevents the harmful effects of high sugar levels on your organs.
    • Rarely causes low blood sugar.
    • Lower the risk of heart attack or stroke.
    Downsides and risks
    MetaglipActos
    Coming soon
    • May take several weeks to lower blood sugar.
    • Can cause weight gain.
    • People with heart failure or history of bladder cancer shouldn't use this medicine.
    • Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
    • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
    Tips from our pharmacists for people taking the medication
    MetaglipActos
    Coming soon
    • Take once a day with or without food.
    • May need several weeks to see full effect on blood sugar control.
    • Can cause weight gain, headache, and swelling from fluid build-up.
    • Tell your doctor about any shortness of breath, heart troubles, or unusual swelling.
    • Not recommended for patients with a history of heart failure or bladder cancer.
    • Check your blood sugar regularly.
    Learn more
    More about MetaglipSide effectsFDA package insert
    Have you used Metaglip (metformin / glipizide)?
    Worth itNot sureNot worth it
    More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Actos (pioglitazone)?
    Worth itNot sureNot worth it