Compare Metaglip vs. Byetta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Metaglip
(Metformin / Glipizide)

Byetta
(Exenatide)

Coming soon.Lowers your blood sugar. Byetta (Exenatide) helps lower blood sugar for people with diabetes and causes weight loss, but it has to be given by injection and many people have upset stomach.
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Reviews & ratings
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Side effects
MetaglipByetta

We haven’t found good data for Metaglip side effects.

FDA side effect reports for Metaglip »
  • Low blood sugar 33%
  • Nausea 26%
  • Vomiting 14%
  • Headache 10%
  • Diarrhea 10%
  • Constipation 8%
  • Indigestion 6%
  • Feeling jittery 5%
  • Muscle weakness 4%
  • Dizziness 3%
More Byetta side effects »
How it works
MetaglipByetta
Coming soon.Byetta (Exenatide) is a medication for diabetes. It stimulates your body to produce and release more insulin, lower the sugar hormone (glucagon), and slow down digestion.
Type of medication
MetaglipByetta
Coming soon.
Anti-diabetic
Incretin mimetic
Prescription only
Available as
MetaglipByetta
  • Pill
  • Injection
Used for (click to learn more)
MetaglipByetta
  • Diabetes mellitus type 2
Risk factors for serious side effects
MetaglipByetta
Coming soon.
        • Severe renal impairment
        • End-stage renal disease
        • Severe gastrointestinal disease
        • Gastroparesis
          Detailed Byetta (Exenatide) risks & warnings »
          Pregnancy category
          MetaglipByetta
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.
          • Give injections in your belly, thighs, or upper arm within an hour of your two main meals of the day (separate doses by 6 or more hours).
          • Eat regular, balanced meals to avoid low blood sugar.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.
          • Can lower your appetite by making you feel full. Some people also lose weight when taking Byetta (Exenatide).
          Upsides and benefits
          MetaglipByetta
          Coming soon.
          • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
          • Prevents the harmful effects of high sugar levels on your organs.
          • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
          • Can lower your appetite by making you feel full. Some people also lose weight when taking Byetta (Exenatide).
          • Byetta (Exenatide) is not a replacement for diabetes pills, but you may be able to use it alone without the need for pills.
          • The injectable “pen” has easy to use doses which you may find more convenient than other types of injections.
          Downsides and risks
          MetaglipByetta
          Coming soon.
          • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
          • Byetta (Exenatide) must be injected twice a day.
          • Up to 40% of people taking Byetta (Exenatide) have upset stomach and side effects like nausea, vomiting, diarrhea, constipation, or indigestion.
          • Because Byetta (Exenatide) can interact with antibiotics and birth control pills, you can't take it until one hour after these medications.
          • Other diabetes medications work as well and are cheaper.
          Tips from our pharmacists for people taking the medication
          MetaglipByetta
          Coming soon.
          • Store in the refrigerator until opening. Do not freeze.
          • Give injections in your belly, thighs, or upper arm within an hour of your two main meals of the day (separate doses by 6 or more hours).
          • Change the needle and prime the pen every time you inject.
          • It’s not safe to share this medication with other people, even if you change the needle.
          • Don’t mix with insulin; give separate injections. Can be given at the same time as insulin, but in different injection areas.
          • Eat regular, balanced meals to avoid low blood sugar.
          • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often, ask your doctor.
          Learn more
          More about MetaglipSide effectsFDA package insert
          More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert