Compare Metaglip vs. Metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(Metformin / Glipizide)


Coming soon.Lowers blood sugar. Glucophage (Metformin) is a very effective medicine to lower blood sugar and the risk of complications and death from diabetes, but it's likely to cause diarrhea for the first few weeks.
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Reviews & ratings
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Reviews for Glucophage (Metformin)
+65% vs. Metaglip (Metformin / Glipizide)
+46% vs. Metaglip (Metformin / Glipizide)
16% vs. Metaglip (Metformin / Glipizide)
929 reviews
Side effects

We haven’t found good data for Metaglip side effects.

FDA side effect reports for Metaglip »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Passing gas 6%
  • Indigestion 3%
  • Muscle weakness 3%
  • Abdominal discomfort 1%
  • Headache 1%
More Metformin side effects »
How it works
Coming soon.Glucophage (Metformin) is an anti-diabetic drug. It lowers sugar production in your body, decreases sugar absorption in your intestines, and makes your body more sensitive to insulin.
Type of medication
Coming soon.
Prescription only
Available as
  • Pill
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
  • Diabetes mellitus type 2
Risk factors for serious side effects
Coming soon.
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
  • Alcohol use
    Detailed Glucophage (Metformin) risks & warnings »
    Pregnancy category
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    No specific alcohol-related info.No specific alcohol-related info.
    No specific food-related info.
    • Always take it with food or switch to the extended release version to avoid upset stomach.
    Kidneys and liver
    No specific kidneys and liver-related info.
    • People with poor kidney function can't use it.
    • Glucophage (Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucophage (Metformin). It may not be a good choice for people with kidney problems. Glucophage (Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.
    • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
    Upsides and benefits
    Coming soon.
    • Oral blood sugar-lowering medicine.
    • A common first treatment for people with newly-diagnosed Type 2 diabetes.
    • The only oral diabetes medicine that lowers complications and deaths from conditions related to diabetes.
    • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Also lowers certain lipid (fat and cholesterol) levels.
    • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
    • You don't have to check your blood sugar every day with this medicine.
    • One of the least expensive diabetes medicines.
    Downsides and risks
    Coming soon.
    • Most people will have nausea, indigestion, or diarrhea in the first few weeks. You can minimize this if you take it on a full stomach.
    • People with poor kidney function can't use it.
    • Only works if your body can still make your own insulin, a hormone that tells your body what to do with sugar, protein, and fat.
    Tips from our pharmacists for people taking the medication
    Coming soon.
    • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
    • Always take it with food or switch to the extended release version to avoid upset stomach.
    • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
    • Check your blood sugar regularly.
    Learn more
    More about MetaglipSide effectsFDA package insert
    More about MetforminSide effectsReviews & ratingsAlternativesFDA package insert