Compare Metformin vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucophage
(Metformin)

Glucotrol
(Glipizide)

Lowers blood sugar. Glucophage (Metformin) is a very effective medicine to lower blood sugar and the risk of complications and death from diabetes, but it's likely to cause diarrhea for the first few weeks.Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.01Metformin
Reviews for Glucophage (Metformin)
65%
of people (All ages) say Glucophage (Metformin) is worth it
46%
say it works well
16%
say it's a big hassle
938 reviews
Have you used Glucophage (Metformin)?
Worth itNot sureNot worth it
Reviews for Glucotrol (Glipizide)
50%
-15% worse vs. Glucophage (Metformin)
32%
-14% worse vs. Glucophage (Metformin)
19%
-3% worse vs. Glucophage (Metformin)
332 reviews
Have you used Glucotrol (Glipizide)?
Worth itNot sureNot worth it
Side effects
MetforminGlucotrol
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Passing gas 6%
  • Muscle weakness 3%
  • Indigestion 3%
  • Abdominal discomfort 1%
  • Headache 1%
More Metformin side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
How it works
MetforminGlucotrol
Glucophage (Metformin) is an anti-diabetic drug. It lowers sugar production in your body, decreases sugar absorption in your intestines, and makes your body more sensitive to insulin.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.
Type of medication
MetforminGlucotrol
Prescription only
Prescription only
Available as
MetforminGlucotrol
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Extended release
Used for
MetforminGlucotrol
Risk factors for serious side effects
MetforminGlucotrol
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
  • Alcohol use
    Detailed Glucophage (Metformin) risks & warnings »
      • Use of other blood sugar lowering medicines
      • Alcohol
      • Intense physical activity
      • History of sulfa allergies
      Detailed Glucotrol (Glipizide) risks & warnings »
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      MetforminGlucotrol
      No alcohol related info.
      • Avoid drinking alcohol.
      Food
      MetforminGlucotrol
      • Always take it with food or switch to the extended release version to avoid upset stomach.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      • Eat regular, balanced meals to avoid low blood sugar.
      Kidneys and liver
      MetforminGlucotrol
      • People with poor kidney function can't use it.
      • Glucophage (Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucophage (Metformin). It may not be a good choice for people with kidney problems. Glucophage (Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      Weight
      MetforminGlucotrol
      • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
      • Can cause mild weight gain (2 to 3 pounds).
      • Can cause weight gain, dizziness, or stomach upset.
      Upsides and benefits
      MetforminGlucotrol
      • Oral blood sugar-lowering medicine.
      • A common first treatment for people with newly-diagnosed Type 2 diabetes.
      • The only oral diabetes medicine that lowers complications and deaths from conditions related to diabetes.
      • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Also lowers certain lipid (fat and cholesterol) levels.
      • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
      • You don't have to check your blood sugar every day with this medicine.
      • One of the least expensive diabetes medicines.
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      • One of the least expensive diabetes medicines.
      Downsides and risks
      MetforminGlucotrol
      • Most people will have nausea, indigestion, or diarrhea in the first few weeks. You can minimize this if you take it on a full stomach.
      • People with poor kidney function can't use it.
      • Only works if your body can still make your own insulin, a hormone that tells your body what to do with sugar, protein, and fat.
      • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
      • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
      • Can cause mild weight gain (2 to 3 pounds).
      • Loses effectiveness over time or as your body stops making insulin.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      Tips from our pharmacists for people taking the medication
      MetforminGlucotrol
      • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
      • Always take it with food or switch to the extended release version to avoid upset stomach.
      • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
      • Check your blood sugar regularly.
      • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
      • Can cause weight gain, dizziness, or stomach upset.
      • Avoid drinking alcohol.
      • Eat regular, balanced meals to avoid low blood sugar.
      • Check your blood sugar regularly.
      Learn more
      More about MetforminSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Glucophage (Metformin)?
      Worth itNot sureNot worth it
      More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Glucotrol (Glipizide)?
      Worth itNot sureNot worth it