Compare metformin vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucophage
(metformin)

Glucovance
(metformin / glyburide)

Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.Lowers blood sugar. Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.
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Reviews & ratings
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5.01metformin
Reviews for Glucophage (metformin)
65%
of people (All ages) say Glucophage (metformin) is worth it
46%
say it works well
16%
say it's a big hassle
938 reviews
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Have you used Glucovance (metformin / glyburide)?
Worth itNot sureNot worth it
Side effects
metforminGlucovance
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Nausea/vomiting 2%
  • Abdominal pain 3%
  • Dizziness 2%
  • Gi side effects 8%
  • Low blood sugar 8%
More Glucovance side effects »
How it works
metforminGlucovance
Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.Glucovance (Metformin / Glyburide) is a combination medication for diabetes. Metformin lowers sugar (glucose) production in your body, decreases the amount of glucose getting into your blood, and makes your body more sensitive to insulin. Glyburide helps your body make more insulin to lower blood sugar.
Type of medication
metforminGlucovance
Prescription only
Prescription only
Available as
metforminGlucovance
  • Pill
  • Extended release pill
  • Liquid
  • Pill
Used for
metforminGlucovance
Risk factors for serious side effects
metforminGlucovance
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
  • Alcohol use
    Detailed Glucophage (metformin) risks & warnings »
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
      • Elderly
      • Use of other blood sugar lowering medicines
      • Alcohol use
      • Intense physical activity
      • History of sulfa reactions
        Detailed Glucovance (metformin / glyburide) risks & warnings »
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Alcohol
        metforminGlucovance
        • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
        • Limit or avoid alcohol when taking this medicine.
        • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
        • Try limiting the amount of alcohol you drink while taking this medication.
        Food
        metforminGlucovance
        • Always take it with food to lessen stomach upset.
        No food related info.
        Kidneys and liver
        metforminGlucovance
        • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
        • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
        • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
        • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
        Weight
        metforminGlucovance
        • Doesn't cause weight gain.
        • Can cause some weight gain.
        Upsides and benefits
        metforminGlucovance
        • Improves sugar control and lowers A1c levels as much as 2%.
        • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
        • Doesn't cause weight gain.
        • Rarely causes low blood sugar.
        • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
        • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
        • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
        • Also lowers certain lipid (fat and cholesterol) levels.
        Downsides and risks
        metforminGlucovance
        • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
        • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
        • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
        • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
        • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
        • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
        • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
        • Can cause some weight gain.
        Tips from our pharmacists for people taking the medication
        metforminGlucovance
        • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
        • Always take it with food to lessen stomach upset.
        • Stay hydrated.
        • Limit or avoid alcohol when taking this medicine.
        • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
        • Check your blood sugar regularly.
        • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
        • Try limiting the amount of alcohol you drink while taking this medication.
        • Check your blood sugar regularly.
        Learn more
        More about metforminSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Glucophage (metformin)?
        Worth itNot sureNot worth it
        More about GlucovanceSide effectsAlternativesFDA package insert
        Have you used Glucovance (metformin / glyburide)?
        Worth itNot sureNot worth it