Compare Metformin vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucophage
(Metformin)

Glucovance
(Metformin / Glyburide)

Lowers blood sugar. Glucophage (Metformin) is a very effective medicine to lower blood sugar and the risk of complications and death from diabetes, but it's likely to cause diarrhea for the first few weeks.Lowers blood sugar. Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.008611410118407Metformin
Reviews for Glucophage (Metformin)
65%
of people say Glucophage (Metformin) is worth it
46%
say it works well
16%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
MetforminGlucovance
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Passing gas 6%
  • Indigestion 3%
  • Muscle weakness 3%
  • Abdominal discomfort 1%
  • Headache 1%
More Metformin side effects »
  • Low blood sugar 35%
  • Gi side effects 14%
  • Diarrhea 11%
  • Abdominal pain 3%
  • Upper respiratory infection 3%
  • Nausea/vomiting 2%
  • Dizziness 2%
More Glucovance side effects »
How it works
MetforminGlucovance
Glucophage (Metformin) is an anti-diabetic drug. It lowers sugar production in your body, decreases sugar absorption in your intestines, and makes your body more sensitive to insulin.Glucovance (Metformin / Glyburide) is a combination medication for diabetes. Metformin lowers sugar (glucose) production in your body, decreases the amount of glucose getting into your blood, and makes your body more sensitive to insulin. Glyburide helps your body make more insulin to lower blood sugar.
Type of medication
MetforminGlucovance
Anti-diabetic
Biguanide
Prescription only
Anti-diabetic
Biguanide
Sulfonylurea
Prescription only
Available as
MetforminGlucovance
  • Pill
  • Extended release
  • Liquid
  • Pill
Used for (click to learn more)
MetforminGlucovance
Risk factors for serious side effects
MetforminGlucovance
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
  • Alcohol use
    Detailed Glucophage (Metformin) risks & warnings »
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
      • Elderly
      • Use of other blood sugar lowering medicines
      • Alcohol use
      • Intense physical activity
      • History of sulfa reactions
        Detailed Glucovance (Metformin / Glyburide) risks & warnings »
        Pregnancy category
        MetforminGlucovance
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.
        • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
        • Try limiting the amount of alcohol you drink while taking this medication.
        Food
        • Always take it with food or switch to the extended release version to avoid upset stomach.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        Kidneys and liver
        • People with poor kidney function can't use it.
        • Glucophage (Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucophage (Metformin). It may not be a good choice for people with kidney problems. Glucophage (Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
        • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
        • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
        • Can cause some weight gain.
        Upsides and benefits
        MetforminGlucovance
        • Oral blood sugar-lowering medicine.
        • A common first treatment for people with newly-diagnosed Type 2 diabetes.
        • The only oral diabetes medicine that lowers complications and deaths from conditions related to diabetes.
        • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
        • You don't have to check your blood sugar every day with this medicine.
        • One of the least expensive diabetes medicines.
        • Also lowers certain lipid (fat and cholesterol) levels.
        • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
        • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
        • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
        • Also lowers certain lipid (fat and cholesterol) levels.
        Downsides and risks
        MetforminGlucovance
        • Most people will have nausea, indigestion, or diarrhea in the first few weeks. You can minimize this if you take it on a full stomach.
        • People with poor kidney function can't use it.
        • Only works if your body can still make your own insulin, a hormone that tells your body what to do with sugar, protein, and fat.
        • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
        • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
        • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
        • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
        • Can cause some weight gain.
        Tips from our pharmacists for people taking the medication
        MetforminGlucovance
        • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
        • Always take it with food or switch to the extended release version to avoid upset stomach.
        • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
        • Check your blood sugar regularly.
        • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
        • Try limiting the amount of alcohol you drink while taking this medication.
        • Check your blood sugar regularly.
        Learn more
        More about MetforminSide effectsReviews & ratingsAlternativesFDA package insert
        More about GlucovanceSide effectsAlternativesFDA package insert