Compare metformin vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucophage
(metformin)

Janumet
(sitagliptin / metformin)

Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.Lowers blood sugar. Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.
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Reviews & ratings
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5.01metformin
Reviews for Glucophage (metformin)
65%
of people (All ages) say Glucophage (metformin) is worth it
46%
say it works well
16%
say it's a big hassle
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Reviews for Janumet (sitagliptin / metformin)
46%
-19% worse vs. Glucophage (metformin)
38%
-8% worse vs. Glucophage (metformin)
15%
+1% better vs. Glucophage (metformin)
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
Side effects
metforminJanumet
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
  • Diarrhea 4%
  • Ear, nose, or throat infection 1%
  • Headache 3%
  • Nausea 4%
  • Abdominal pain 1%
  • Vomiting 2%
More Janumet side effects »
How it works
metforminJanumet
Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.
Type of medication
metforminJanumet
Prescription only
Prescription only
Available as
metforminJanumet
  • Pill
  • Extended release pill
  • Liquid
  • Pill
  • Extended release
Used for
metforminJanumet
Risk factors for serious side effects
metforminJanumet
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
  • Alcohol use
    Detailed Glucophage (metformin) risks & warnings »
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Contrast dye for procedure
    • Surgery
    • Alcohol use
          Detailed Janumet (sitagliptin / metformin) risks & warnings »
          Pregnancy

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Alcohol
          metforminJanumet
          • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
          • Limit or avoid alcohol when taking this medicine.
          No alcohol related info.
          Food
          metforminJanumet
          • Always take it with food to lessen stomach upset.
          • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
          Kidneys and liver
          metforminJanumet
          • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
          • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
          • People with poor kidney function can't use it.
          • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
          Weight
          metforminJanumet
          • Doesn't cause weight gain.
          • Doesn't cause weight gain or low blood sugar.
          Upsides and benefits
          metforminJanumet
          • Improves sugar control and lowers A1c levels as much as 2%.
          • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
          • Doesn't cause weight gain.
          • Rarely causes low blood sugar.
          • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
          • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
          • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
          • Doesn't cause weight gain or low blood sugar.
          • You don't have to check your blood sugar every day with this medicine.
          Downsides and risks
          metforminJanumet
          • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
          • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
          • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
          • Likely expensive since there's no generic version available.
          • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
          • People with poor kidney function can't use it.
          • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
          • Might raise the risk of problems with your pancreas.
          Tips from our pharmacists for people taking the medication
          metforminJanumet
          • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
          • Always take it with food to lessen stomach upset.
          • Stay hydrated.
          • Limit or avoid alcohol when taking this medicine.
          • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
          • Check your blood sugar regularly.
          • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
          • May cause headaches and cold-like symptoms.
          • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
          • Can be expensive depending on insurance coverage.
          • Check your blood sugar regularly.
          Learn more
          More about metforminSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Glucophage (metformin)?
          Worth itNot sureNot worth it
          More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Janumet (sitagliptin / metformin)?
          Worth itNot sureNot worth it