Compare metformin vs. Prandin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucophage
(metformin)

Prandin
(repaglinide)

Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.Lowers blood sugar. Prandin (repaglinide) works quickly to lower blood sugar, especially during mealtimes. However, it can cause hypoglycemia (low blood sugar) if you are not consistent with your diet and exercise schedule.
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Reviews & ratings
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5.01metformin
Reviews for metformin
65%
of people (All ages) say metformin is worth it
46%
say it works well
16%
say it's a big hassle
938 reviews
Have you used Glucophage (metformin)?
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Have you used Prandin (repaglinide)?
Worth itNot sureNot worth it
Side effects
metforminPrandin
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
  • Common cold 8%
  • Low blood sugar 24%
  • Headache 1%
  • Joint pain 3%
  • Sinus inflammation 4%
  • Diarrhea 3%
  • Back pain 1%
  • Swelling in arms and legs 5%
  • Heart failure 4%
More Prandin side effects »
How it works
metforminPrandin
Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.Prandin (repaglinide) stimulates your body to produce more insulin.
Type of medication
metforminPrandin
Prescription onlyPrescription only
Available as
metforminPrandin
  • Pill
  • Extended release pill
  • Liquid
  • Pill
Used for
metforminPrandin
Risk factors for serious side effects
metforminPrandin
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Glucophage (metformin) risks & warnings »
  • Alcoholism
  • Changes in meal pattern
  • Changes in exercise
  • Insulin
  • Other antidiabetic medications
Detailed Prandin (repaglinide) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
metforminPrandin
  • Limit or avoid alcohol when taking this medicine.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
No alcohol related info.
Food
metforminPrandin
  • Always take it with food to lessen stomach upset.
  • If you skip a meal, skip your dose to prevent hypoglycemia (low blood sugar).
  • Quickly and effectively lowers blood sugar during meal times.
Kidneys and liver
metforminPrandin
  • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
Weight
metforminPrandin
  • Doesn't cause weight gain.
  • May cause some weight gain.
Upsides and benefits
metforminPrandin
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
  • Quickly and effectively lowers blood sugar during meal times.
  • Less likely to cause hypoglycemia (low blood sugar) than Starlix (nateglinide).
  • Good first-choice if you cannot tolerate metformin or add-on therapy if your blood sugars are not controlled on metformin alone.
Downsides and risks
metforminPrandin
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
  • May cause some weight gain.
  • May cause hypoglycemia (low blood sugar).
  • Can frequently interfere with how other medicines work.
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
Tips from our pharmacists for people taking the medication
metforminPrandin
  • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
  • Always take it with food to lessen stomach upset.
  • Stay hydrated.
  • Limit or avoid alcohol when taking this medicine.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Check your blood sugar regularly.
  • Works quickly to lower blood sugar so should be taken 15 to 30 minutes before a meal.
  • If you skip a meal, skip your dose to prevent hypoglycemia (low blood sugar).
  • Maintain a regular diet and exercise schedule while on this medicine to prevent fluctuations in your blood sugar.
Learn more
More about metforminSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
More about PrandinSide effectsAlternativesFDA package insert
Have you used Prandin (repaglinide)?
Worth itNot sureNot worth it