Metformin vs. Precose

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Scroll horizontally → to see comparisons



Lowers blood sugar. Glucophage (Metformin) is a very effective medicine to lower blood sugar and the risk of complications and death from diabetes, but it's likely to cause diarrhea for the first few weeks.Coming soon.
How it works
Glucophage (Metformin) is an anti-diabetic drug. It lowers sugar production in your body, decreases sugar absorption in your intestines, and makes your body more sensitive to insulin.Coming soon.
Type of medication
Prescription only
Coming soon.
Available as
  • Pill
  • Extended release
  • Liquid
  • Pill
Used for (click to learn more)
  • Diabetes mellitus type 2
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Glucophage (Metformin)
of people say Glucophage (Metformin) is worth it
say it works well
say it's a big hassle
Side effects
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Passing gas 6%
  • Indigestion 3%
  • Muscle weakness 3%
  • Abdominal discomfort 1%
  • Headache 1%
More Metformin side effects »

We haven’t found good data for Precose side effects.

FDA side effect reports for Precose »
Risk factors for serious side effects
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
  • Alcohol use
    Detailed Glucophage (Metformin) risks & warnings »
    Coming soon.
    Pregnancy category
    No specific alcohol-related info.No specific alcohol-related info.
    • Always take it with food or switch to the extended release version to avoid upset stomach.
    No specific food-related info.
    Kidneys and liver
    • People with poor kidney function can't use it.
    • Glucophage (Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucophage (Metformin). It may not be a good choice for people with kidney problems. Glucophage (Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
    No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
    No specific weight-related info.
    Upsides and benefits
    • Oral blood sugar-lowering medicine.
    • A common first treatment for people with newly-diagnosed Type 2 diabetes.
    • The only oral diabetes medicine that lowers complications and deaths from conditions related to diabetes.
    • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Also lowers certain lipid (fat and cholesterol) levels.
    • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
    • You don't have to check your blood sugar every day with this medicine.
    • One of the least expensive diabetes medicines.
    Coming soon.
    Downsides and risks
    • Most people will have nausea, indigestion, or diarrhea in the first few weeks. You can minimize this if you take it on a full stomach.
    • People with poor kidney function can't use it.
    • Only works if your body can still make your own insulin, a hormone that tells your body what to do with sugar, protein, and fat.
    Coming soon.
    Tips from our pharmacists for people taking the medication
    • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
    • Always take it with food or switch to the extended release version to avoid upset stomach.
    • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
    • Check your blood sugar regularly.
    Coming soon.
    Learn more
    More about MetforminSide effectsReviews & ratingsAlternativesFDA package insert
    More about PrecoseSide effectsReviews & ratingsFDA package insert