Compare methotrexate vs. Remicade

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Otrexup (methotrexate)

Prescription only

Remicade (infliximab)

Prescription only
Reduces inflammation and cell replication.

Otrexup (methotrexate) is the first-choice treatment for many types of cancer and arthritis, but it has many side effects.

Calms down your immune system.

Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.

5.4/ 7 average rating with 55 reviewsforRemicade
Upsides
  • Otrexup (methotrexate) is available as an affordable generic form.
  • Otrexup (methotrexate) comes as a tablet, an injection that you give yourself, or an infusion that you get in the doctor's office or infusion center.
  • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
  • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
  • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
  • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
  • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
Downsides
  • You may need frequent blood tests for monitoring when taking Otrexup (methotrexate).
  • Otrexup (methotrexate) can cause serious birth defects so women should avoid getting pregnant for at least 6 month and men 3 months after taking it.
  • While on Otrexup (methotrexate), you should avoid alcohol and staying out in the sun for too long.
  • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
  • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
  • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
  • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
  • No generic available, so it can be costly.
Used for
Dosage forms
  • Pill
  • Injection
  • Liquid
  • Injection
Price
Lowest price near you
$31.32
Find instant savings
Lowest price near you
$21448.1
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
Not enough review data.Leave a review
55 
76%
think this treatment is worth it
62%
think this treatment works well
15%
think this treatment is a hassle

Have you used Remicade (infliximab)?

Leave a review
Side effects
The Otrexup (methotrexate) FDA package insert doesn’t have numbers about how common side effects are.
The Remicade (infliximab) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Worsening side-effects

    Reduced kidney function

    ...and 2 more risk factors

  • Use of NSAIDs

    NSAIDS

    ...and 1 more risk factors

  • Liver problems

    Long-term use

    ...and 1 more risk factors

  • Diarrhea and mouth sores

    Taking Otrexup (methotrexate) with high-dose NSAIDs

  • Tumor lysis syndrome

    Rapidly growing tumors

  • Skin and bone tissue deterioration

    Radiotherapy

See more detailed risks and warnings
  • Serious infections

    Taking other immunosuppressant drugs

    ...and 2 more risk factors

  • Cancer

    Taking other immunosuppressant drugs

    ...and 1 more risk factors

  • Heart failure

    History of heart failure

    ...and 1 more risk factors

  • Nervous system effects

    History of nerve problems

  • Lower blood cell counts

    Ongoing or history of blood problems

See more detailed risks and warnings