Compare Methyltestosterone vs. Axiron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Android
(Methyltestosterone)

Axiron
(Testosterone Topical Solution)

Treats low testosterone. Android (Methyltestosterone) is an oral form of testosterone that's easy to take but not available as a generic yet.Treats low testosterone. This testosterone topical solution is a convenient topical form of hormone replacement that's less likely to rub off on other people you come into contact with, but it's not available as a generic yet.
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Side effects
MethyltestosteroneAxiron

The Methyltestosterone FDA package insert doesn’t have numbers about how common side effects are.

More about Methyltestosterone side effects »

The Axiron FDA package insert doesn’t have numbers about how common side effects are.

More about Axiron side effects »
How it works
MethyltestosteroneAxiron
Android (Methyltestosterone) works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on. Also, it can slow the spread of certain kinds of breast cancer.Testosterone topical solution works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
MethyltestosteroneAxiron
Hormone replacement
Testosterone
Prescription only
Hormone replacement
Testosterone
Prescription only
Available as
MethyltestosteroneAxiron
  • Pill
  • Topical
Used for (click to learn more)
MethyltestosteroneAxiron
  • Low testosterone
  • Low testosterone
Risk factors for serious side effects
MethyltestosteroneAxiron
  • Male
  • Male
  • Enlarged prostate (benign prostatic hypertrophy)
  • Taking high doses of Android (Methyltestosterone)
  • Heart, liver or kidney disease
  • Female
  • Breast cancer
  • Inability to move
      • Diabetes
      • On blood thinners
        Detailed Android (Methyltestosterone) risks & warnings »
        Coming soon.
        Pregnancy category
        MethyltestosteroneAxiron
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        • There have been reports of people on Android (Methyltestosterone) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This has happened if you have breast cancer or if you are unable to move around. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
        No specific kidneys and liver-related info.
        Sex
        • Can cause increased acne and changes in sex drive.
        • If you're a man taking Android (Methyltestosterone), you can see changes in your sex drive, including overstimulation and prolonged frequent erections. Talk to your doctor if this happens, since they might have to change the dose.
        No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        • If you're taking Android (Methyltestosterone), and you notice swelling in your legs, or a sudden increase in your weight, talk to your doctor. This can be a serious side effect involving your heart.
        No specific weight-related info.
        Upsides and benefits
        MethyltestosteroneAxiron
        • A first-choice treatment for men with low testosterone.
        • Oral form of testosterone that some people prefer over injections and topical gels and patches.
        • You're less likely with this formulation to transfer testosterone topical solution to another person since this is applied to the armpits -- unlike some other forms of topical testosterone.
        • You can use your regular deodorant or antiperspirant, but just make sure to apply that first before using testosterone topical solution.
        Downsides and risks
        MethyltestosteroneAxiron
        • Not a first-choice treatment for breast cancers that respond to testosterone.
        • Not available as generic, so it can be expensive.
        • Only available as brand name.
        • You have to wait at least 2 hours after applying testosterone topical solution before you can swim or bathe, otherwise your body won't absorb the entire amount.
        Tips from our pharmacists for people taking the medication
        MethyltestosteroneAxiron
        • Can cause nausea, vomiting, and headache.
        • Don't double up if you miss a dose.
        • Can cause increased acne and changes in sex drive.
        • Keep this medication locked up and away from children since it's a controlled substance.
        • Prime testosterone topical solution first by pumping 3 times before you use a new bottle.
        • If you use deodorant or antiperspirant, apply that first before using testosterone topical solution.
        • Don't swim or bathe for at least 2 hours after you put on testosterone topical solution so that it has time to absorb.
        • Cover the area with clothing as soon as it's dry so you don't spread it to other people.
        • If you think you'll have skin-to-skin contact at the area where you've placed testosterone topical solution, wash that area with soap and water then dry.
        • Don't use testosterone topical solution anywhere besides your armpits.
        Learn more
        More about MethyltestosteroneSide effectsAlternativesFDA package insert
        More about AxironSide effectsReviews & ratingsAlternativesFDA package insert