Compare Methyltestosterone vs. Depo-Testosterone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Android
(Methyltestosterone)

Depo-Testosterone
(Testosterone Cypionate Injection)

Treats low testosterone. Android (Methyltestosterone) is an oral form of testosterone that's easy to take but not available as a generic yet.Treats low testosterone. This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.
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Reviews & ratings
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Reviews for Depo-Testosterone (Testosterone Cypionate Injection)
48%
+48% vs. Android (Methyltestosterone)
31%
+31% vs. Android (Methyltestosterone)
17%
17% vs. Android (Methyltestosterone)
Side effects
MethyltestosteroneDepo-Testosterone

The Methyltestosterone FDA package insert doesn’t have numbers about how common side effects are.

More about Methyltestosterone side effects »

The Depo-Testosterone FDA package insert doesn’t have numbers about how common side effects are.

More about Depo-Testosterone side effects »
How it works
MethyltestosteroneDepo-Testosterone
Android (Methyltestosterone) works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on. Also, it can slow the spread of certain kinds of breast cancer.The testosterone injection works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
MethyltestosteroneDepo-Testosterone
Hormone replacement
Testosterone
Prescription only
Hormone replacement
Testosterone
Prescription only
Available as
MethyltestosteroneDepo-Testosterone
  • Pill
  • Injection
Used for (click to learn more)
MethyltestosteroneDepo-Testosterone
  • Low testosterone
  • Low testosterone
Risk factors for serious side effects
MethyltestosteroneDepo-Testosterone
  • Male
  • Male
  • Enlarged prostate (benign prostatic hypertrophy)
  • Taking high doses of Android (Methyltestosterone)
  • Heart, liver or kidney disease
  • Female
  • Breast cancer
  • Inability to move
      • Diabetes
      • On blood thinners
        Detailed Android (Methyltestosterone) risks & warnings »
        • Male
        • Male
        • Enlarged prostate (benign prostatic hypertrophy)
        • Taking high doses of Depo-Testosterone (Testosterone Cypionate Injection)
        • Heart, liver or kidney disease
        • Inability to move
        • Cancer
            • Diabetes
            • On blood thinners
              Detailed Depo-Testosterone (Testosterone Cypionate Injection) risks & warnings »
              Pregnancy category
              MethyltestosteroneDepo-Testosterone
              XFDA pregnancy category (Unsafe)

              Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

              See the FDA package insert
              XFDA pregnancy category (Unsafe)

              Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              No specific food-related info.No specific food-related info.
              Kidneys and liver
              • There have been reports of people on Android (Methyltestosterone) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This has happened if you have breast cancer or if you are unable to move around. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
              • There have been reports of people on Depo-Testosterone (Testosterone Cypionate Injection) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This can happen if you are unable to move around or have cancer. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
              Sex
              • Can cause increased acne and changes in sex drive.
              • If you're a man taking Android (Methyltestosterone), you can see changes in your sex drive, including overstimulation and prolonged frequent erections. Talk to your doctor if this happens, since they might have to change the dose.
              • Can cause increased acne and changes in sex drive.
              • If you're a man taking Depo-Testosterone (Testosterone Cypionate Injection), you can see changes in your sex drive, including overstimulation and prolonged frequent erections. Talk to your doctor if this happens, since they might have to change the dose.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              • If you're taking Android (Methyltestosterone), and you notice swelling in your legs, or a sudden increase in your weight, talk to your doctor. This can be a serious side effect involving your heart.
              • If you're taking Depo-Testosterone (Testosterone Cypionate Injection), and you notice swelling in your legs, or a sudden increase in your weight, talk to your doctor. This can be a serious side effect involving your heart.
              Upsides and benefits
              MethyltestosteroneDepo-Testosterone
              • A first-choice treatment for men with low testosterone.
              • Oral form of testosterone that some people prefer over injections and topical gels and patches.
              • A first-choice treatment for low testosterone in men and delayed puberty in boys.
              • Available in generic.
              • Only has to be given once every 2 to 4 weeks.
              • The shot can be done at home.
              Downsides and risks
              MethyltestosteroneDepo-Testosterone
              • Not a first-choice treatment for breast cancers that respond to testosterone.
              • Not available as generic, so it can be expensive.
              • Only available as a shot.
              • Has to be given by someone else since it has to be injected into your buttocks.
              Tips from our pharmacists for people taking the medication
              MethyltestosteroneDepo-Testosterone
              • Can cause nausea, vomiting, and headache.
              • Don't double up if you miss a dose.
              • Can cause increased acne and changes in sex drive.
              • Keep this medication locked up and away from children since it's a controlled substance.
              • Your doctor will show you how to inject this correctly.
              • Can cause nausea, vomiting and headache.
              • Can cause increased acne and changes in sex drive.
              • Keep this medication locked up and away from children since it's a controlled substance.
              Learn more
              More about MethyltestosteroneSide effectsAlternativesFDA package insert
              More about Depo-TestosteroneSide effectsReviews & ratingsAlternativesFDA package insert