Compare Minivelle vs. Combipatch

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves menopause symptoms.

The Minivelle (estradiol patch) is the mini-me of estrogen patches. It's used twice a week, available in five strengths, and has the least amount of skin irritation.

4.2/ 5 average rating with 17 reviewsforMinivelle
Treats low estrogen and relieves menopause symptoms.

Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.

Upsides
  • Minivelle (estradiol patch) is the smallest estrogen patch available. It's the size a dime and comes in 5 different strengths.
  • Causes little or no skin irritation and doesn't leave much adhesive on your skin.
  • Minivelle (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
  • Twice weekly patch. Good for people who don't want to take daily pills.
  • Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
  • Good for women with an intact uterus.
  • You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
Downsides
  • You need to replace Minivelle (estradiol patch) twice a week, compared to other patches that are once a week.
  • Patches can fall off.
  • Increases your risk of uterine and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
  • More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can't be exposed to direct sunlight for long periods of time.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Hot flashes
  • Prevention of bone thinning in postmenopausal women
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
Dosage forms
  • Patch
  • Patch
Price
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Reviews
17 reviews so far
82%
saidit'sworth it
76%
saiditworked well
18%
saidit'sa big hassle

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Side effects
20possible side effects
  • Headache
    26%
  • Breast pain
    13%
  • Back pain
    11%
  • Menstrual bleeding
    11%
  • Influenza
    8%
  • Common cold
    8%
  • Nausea
    5%
  • Pain
    5%
  • Sinus infection
    5%
  • Lung infection
    5%
  • Neck pain
    5%
  • Limb pain
    5%
  • Sinus congestion
    5%
  • Joint pain
    4%
  • Depression
    3%
  • Constipation
    2%
  • Flu-like symptoms
    2%
  • Sinus headache
    2%
  • Anxiety
    2%
  • Trouble sleeping
    2%
See more detailed side effects
36possible side effects
  • Breast pain
    34%
  • Menstrual cramps
    30%
  • Headache
    25%
  • Skin irritation
    20%
  • Pain
    19%
  • Stuffy nose
    19%
  • Menstrual problems
    17%
  • Back pain
    15%
  • Flu like symptoms
    14%
  • Diarrhea
    14%
  • Lung infection
    13%
  • Stomach pain
    12%
  • Accidental injury
    10%
  • Weakness
    10%
  • Sinus infection
    10%
  • Vaginal discharge
    10%
  • Sore throat
    9%
  • Vaginal inflammation
    9%
  • Upset stomach
    8%
  • Nausea
    8%
  • Depression
    8%
  • Trouble sleeping
    8%
  • Gas
    7%
  • Tooth problems
    6%
  • Swelling in the arms and legs
    6%
  • Joint pain
    6%
  • Dizziness
    6%
  • Rash
    6%
  • Infection
    5%
  • Nervousness
    5%
  • Airway inflammation
    5%
  • Acne
    4%
  • Unusual menstrual bleeding
    3%
  • Constipation
    2%
  • Breast growth
    2%
  • Heavy menstrual bleeding
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Dementia
    • Aged 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
  • Gallbladder problems
See more detailed risks and warnings