Compare Minivelle vs. Estradiol Norethindrone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Minivelle (estradiol patch)

Prescription only
Relieves menopause symptoms.

The Minivelle (estradiol patch) is the mini-me of estrogen patches. It's used twice a week, available in five strengths, and has the least amount of skin irritation.

5.8/ 7 average rating with 17 reviewsforMinivelle
Relieves menopause symptoms and lowers your risk of osteoporosis.

Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.

Upsides
  • Minivelle (estradiol patch) is the smallest estrogen patch available. It's the size a dime and comes in 5 different strengths.
  • Causes little or no skin irritation and doesn't leave much adhesive on your skin.
  • Minivelle (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
Downsides
  • You need to replace Minivelle (estradiol patch) twice a week, compared to other patches that are once a week.
  • Patches can fall off.
  • Increases your risk of uterine and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Used for
  • Hot flashes
  • Prevention of bone thinning in postmenopausal women
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Prevention of postmenopausal osteoporosis
Dosage forms
  • Patch
  • Pill
Price
Lowest price near you
$159.68
Find instant savings
Lowest price near you
$39.12
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
17 
82%
think this treatment is worth it
76%
think this treatment works well
18%
think this treatment is a hassle

Have you used Minivelle (estradiol patch)?

Leave a review
Not enough review data.Leave a review
Side effects
10possible side effects
  • Headache
    26%
  • Breast pain
    13%
  • Back pain
    11%
  • Menstrual bleeding
    11%
  • Influenza
    8%
  • Common cold
    8%
  • Nausea
    5%
  • Pain
    5%
  • Sinus infection
    5%
  • Lung infection
    5%
See more detailed side effects
10possible side effects
  • Breast Pain
    24%
  • Upper Respiratory Tract Infection
    18%
  • Headache
    16%
  • Sinusitis
    7%
  • Back Pain
    6%
  • Insomnia
    6%
  • Post-Menopausal Bleeding
    5%
  • Uterine Fibroid
    5%
  • Infection Viral
    4%
  • Moniliasis Genital
    4%
See more detailed side effects
Risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Dementia

    Age 65 or older

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 2 more risk factors

  • Harm to fetus

    Women of childbearing age

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

  • Ovarian cancer

    Family history of ovarian cancer

See more detailed risks and warnings