Compare Minivelle vs. Evamist

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Minivelle
(estradiol patch)

Evamist
(estradiol spray)

Relieves hot flashes due to menopause and lowers your risk of osteoporosis. The Minivelle (Estradiol Patch) is the mini-me of estrogen patches. It's used twice a week, available in five strengths, and has the least amount of skin irritation.Relieves hot flashes due to menopause. Evamist (Estradiol Spray) is easy to use, absorbs well into your skin without needing to rub it in, and is a good option if you don’t want to use estrogen pills or patches.
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Reviews & ratings
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Have you used Minivelle (estradiol patch)?
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Have you used Evamist (estradiol spray)?
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Side effects
MinivelleEvamist
  • Breast tenderness 17%
  • Low mood disorder 7%
  • Back pain 3%
  • Weight increased 7%
  • Indigestion 3%
More Minivelle side effects »
  • Headache 3%
  • Breast tenderness 4%
  • Nasopharyngitis (common cold) 3%
  • Nipple pain 2%
  • Back pain 1%
  • Nausea 1%
  • Arthralgia (joint pain) 3%
More Evamist side effects »
How it works
MinivelleEvamist
The Minivelle (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.Evamist (Estradiol Spray) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
Type of medication
MinivelleEvamist
Prescription only
Prescription only
Available as
MinivelleEvamist
  • Patch
  • Spray
Used for
MinivelleEvamist
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
MinivelleEvamist
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
  • High levels of triglycerides
Detailed Minivelle (estradiol patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
    Detailed Evamist (estradiol spray) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Alcohol
    MinivelleEvamist
    No alcohol related info.
    • The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.
    Weight
    MinivelleEvamist
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    Upsides and benefits
    MinivelleEvamist
    • The [name_comon] is the smallest estrogen patch available. It's the size a dime and comes in 5 different strengths.
    • You’ll need to replace it twice a week, every 3 to 4 days.
    • Causes little or no skin irritation and doesn't leave adhesive on your skin.
    • The Minivelle (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
    • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
    • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    • Improves mood, energy, and mental alertness for some people.
    • Evamist (Estradiol Spray) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy).
    • Dries faster than topical estrogen gels.
    • Good for people who don't want to take daily pills.
    • Fewer side effects than pills since lower amounts of estrogen are used in topical sprays.
    • Women in studies have seen the severity and number of hot flashes lower by half within 4 weeks of using Evamist (Estradiol Spray).
    • Very few women had skin irritation from the medicine.
    • Depending on your symptoms, your dose may change, but you can still use the same spray pump no matter what your dose is.
    • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    Downsides and risks
    MinivelleEvamist
    • You need to replace the Minivelle (Estradiol Patch) twice a week, compared to other patches that are once a week.
    • Patch can fall off.
    • Increases your risk of uterine and breast cancer.
    • If you have your uterus, you have to use the Minivelle (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
    • Can't be used in people with liver problems.
    • Increases your risk of endometrial and breast cancer.
    • If you have your uterus, you have to use Evamist (Estradiol Spray) with another hormone called progestin to lower your risk of uterine cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can't be used in people with liver problems.
    • It's possible to expose other people to the estrogen before it's absorbed by your skin.
    • Can be expensive since it's only available as a brand name product.
    Tips from our pharmacists for people taking the medication
    MinivelleEvamist
    • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
    • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
    • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
    • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
    • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Tell your doctor about any unusual vaginal bleeding.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    • Spray with the container upright and the cone flat against your skin on the inside of your forearm. If more than one spray is needed, always use a different area on your forearm.
    • Don't put it on your face, breasts, vagina, or irritated skin.
    • Don't rub it in. Let the spray dry for about 2 minutes before dressing, and don't get the application site wet for at least 1 hour.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Tell your doctor about any unusual vaginal bleeding.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    • The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.
    Learn more
    More about MinivelleSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Minivelle (estradiol patch)?
    Worth itNot sureNot worth it
    More about EvamistSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Evamist (estradiol spray)?
    Worth itNot sureNot worth it