Compare Mirapex vs. carbidopa / levodopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mirapex
(pramipexole)

Sinemet
(carbidopa / levodopa)

Helps with movement problems. Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.Treats Parkinson's disease. Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.
Reviews & ratings
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Have you used Mirapex (pramipexole)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Sinemet (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
Mirapexcarbidopa / levodopa
  • Any side effect 1%
  • Hallucinations 3%
  • Dizziness 1%
  • Somnolence 2%
  • Nausea 2%
  • Insomnia 5%
  • Constipation 8%
  • Asthenia 2%
  • Postural hypotension 5%
More Mirapex side effects »

The carbidopa / levodopa FDA package insert doesn’t have numbers about how common side effects are.

More about carbidopa / levodopa side effects »
How it works
Mirapexcarbidopa / levodopa
Mirapex (Pramipexole) is a dopamine agonist. It binds to receptors in the brain and helps improve movement in people with Parkinson's disease or restless leg syndrome.Sinemet (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa prevents breakdown of levodopa allowing it to enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
Mirapexcarbidopa / levodopa
Prescription onlyPrescription only
Available as
Mirapexcarbidopa / levodopa
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
Used for
Mirapexcarbidopa / levodopa
Risk factors for serious side effects
Mirapexcarbidopa / levodopa
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Taking blood pressure-lowering medicines
  • Current kidney problems
  • Parkinson's disease
Detailed Mirapex (pramipexole) risks & warnings »
  • Taking other medicines for Parkinson's
  • Stopping Sinemet (carbidopa / levodopa) suddenly
  • Taking other medicines for Parkinson's disease
Detailed Sinemet (carbidopa / levodopa) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
Mirapexcarbidopa / levodopa
  • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
No food related info.
Kidneys and liver
Mirapexcarbidopa / levodopa
  • Mirapex (Pramipexole) is processed by the kidney. If you have kidney problems, talk to your doctor because you may need a different dose.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
No kidneys and liver related info.
Sleep
Mirapexcarbidopa / levodopa
No sleep related info.
  • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Can make you very sleepy.
Upsides and benefits
Mirapexcarbidopa / levodopa
  • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
  • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
  • Is effective for treating restless leg syndrome.
  • Available in a short-acting and a long-acting form.
  • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
  • Sinemet (carbidopa / levodopa) is available in generic.
Downsides and risks
Mirapexcarbidopa / levodopa
  • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
  • Mirapex (Pramipexole) can cause hallucinations in older people.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
  • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
  • Can make you very sleepy.
  • Can stain your saliva, sweat and urine a dark color.
  • Will lose its effect over time as your disease progresses.
  • May need to be taken several times during day to control symptoms of Parkinson's disease
  • May cause unusual cravings in some people.
Tips from our pharmacists for people taking the medication
Mirapexcarbidopa / levodopa
  • You should start Mirapex (Pramipexole) at a low dose and your doctor will raise the dose slowly. This will help lower your risk of side effects, such as drowsiness and low blood pressure.
  • Can cause intense urges and compulsive behaviors that are hard to control, such as binge eating, gambling, and sexual urges. Talk to your doctor right away if you have any of these feelings.
  • You can suddenly fall asleep without warning while on this medicine. Don't perform any tasks that require mental alertness, like driving, or drinking alcohol until you know how Mirapex (Pramipexole) affects you. Let your doctor know if you have a history of sleep problems.
  • Take Mirapex (Pramipexole) 2 to 3 hours before bedtime for restless leg syndrome.
  • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
  • Can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Can stain your saliva, sweat and urine a dark color.
  • Take Sinemet (carbidopa / levodopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
  • If you notice Sinemet (carbidopa / levodopa) wearing off sooner than you'd like, talk to your doctor. How much and how often you take it may need to be adjusted.
  • Sinemet (carbidopa / levodopa) may cause unusual cravings in some people.
Learn more
More about MirapexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Mirapex (pramipexole)?
Worth itNot sureNot worth it
More about carbidopa / levodopaSide effectsAlternativesFDA package insert
Have you used Sinemet (carbidopa / levodopa)?
Worth itNot sureNot worth it