Compare Mirapex vs. carbidopa / levodopa extended release

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mirapex
(pramipexole)

Sinemet CR
(carbidopa / levodopa extended release)

Helps with movement problems. Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.Treats Parkinson's disease. Sinemet CR (carbidopa / levodopa extended release) is the first choice treatment for Parkinson's disease.
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Coupons for Mirapex
Best available price for 30 (0.25mg) tablets of pramipexole
Best available price for 90 (50mg/200mg) tablets of carbidopa-levodopa-er
Reviews & ratings
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Have you used Mirapex (pramipexole)?
Worth itNot sureNot worth it

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Have you used Sinemet CR (carbidopa / levodopa extended release)?
Worth itNot sureNot worth it
Side effects
Mirapexcarbidopa / levodopa extended release
  • Any side effect 1%
  • Hallucinations 3%
  • Dizziness 1%
  • Drowsiness 2%
  • Nausea 2%
  • Sleep difficulty 5%
  • Constipation 8%
  • Muscle weakness 2%
  • Positional low blood pressure 5%
More Mirapex side effects »
  • Difficulty controlling movements 17%
  • Nausea 6%
  • Hallucinations 4%
  • Confusion 4%
  • Dizziness 3%
  • Low mood disorder 2%
  • Urinary tract infection 2%
  • Back pain 2%
  • Unusual dreams 2%
  • Muscle spasms 2%
More carbidopa / levodopa extended release side effects »
How it works
Mirapexcarbidopa / levodopa extended release
Mirapex (Pramipexole) is a dopamine agonist. It binds to receptors in the brain and helps improve movement in people with Parkinson's disease or restless leg syndrome.Sinemet CR (carbidopa / levodopa extended release) is a combination of carbidopa and levodopa that is released in your body over time. Carbidopa prevents breakdown of levodopa so that levodopa can then, enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
Mirapexcarbidopa / levodopa extended release
Prescription onlyPrescription only
Available as
Mirapexcarbidopa / levodopa extended release
  • Pill
  • Extended release
  • Extended release
Used for
Mirapexcarbidopa / levodopa extended release
Risk factors for serious side effects
Mirapexcarbidopa / levodopa extended release
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Taking blood pressure-lowering medicines
  • Current kidney problems
  • Parkinson's disease
Detailed Mirapex (pramipexole) risks & warnings »
  • Taking other medicines for Parkinson's
  • Stopping Sinemet CR (carbidopa / levodopa extended release) suddenly
  • Taking other medicines for Parkinson's disease
Detailed Sinemet CR (carbidopa / levodopa extended release) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
Mirapexcarbidopa / levodopa extended release
  • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
No food related info.
Kidneys and liver
Mirapexcarbidopa / levodopa extended release
  • Mirapex (Pramipexole) is processed by the kidney. If you have kidney problems, talk to your doctor because you may need a different dose.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
No kidneys and liver related info.
Upsides and benefits
Mirapexcarbidopa / levodopa extended release
  • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
  • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
  • Is effective for treating restless leg syndrome.
  • Available in a short-acting and a long-acting form.
  • Sinemet CR (carbidopa / levodopa extended release) is released over a long period of time in your body and can allow you to take fewer pills less frequently.
Downsides and risks
Mirapexcarbidopa / levodopa extended release
  • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
  • Mirapex (Pramipexole) can cause hallucinations in older people.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
  • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
  • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
  • Sinemet CR (carbidopa / levodopa extended release) will lose its effect over time. If you notice it wearing off sooner than you'd like, talk to your doctor.
  • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
Tips from our pharmacists for people taking the medication
Mirapexcarbidopa / levodopa extended release
  • You should start Mirapex (Pramipexole) at a low dose and your doctor will raise the dose slowly. This will help lower your risk of side effects, such as drowsiness and low blood pressure.
  • Can cause intense urges and compulsive behaviors that are hard to control, such as binge eating, gambling, and sexual urges. Talk to your doctor right away if you have any of these feelings.
  • You can suddenly fall asleep without warning while on this medicine. Don't perform any tasks that require mental alertness, like driving, or drinking alcohol until you know how Mirapex (Pramipexole) affects you. Let your doctor know if you have a history of sleep problems.
  • Take Mirapex (Pramipexole) 2 to 3 hours before bedtime for restless leg syndrome.
  • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
  • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
  • Take Sinemet CR (carbidopa / levodopa extended release) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
  • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
Learn more
More about MirapexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Mirapex (pramipexole)?
Worth itNot sureNot worth it
More about carbidopa / levodopa extended releaseSide effectsAlternativesFDA package insert
Have you used Sinemet CR (carbidopa / levodopa extended release)?
Worth itNot sureNot worth it